Mechanism Of Neuromuscular Transmission

Question 1

During presynaptic event, AP causes activates and open ______ channels causing ______ influx. Migration of _____ to presynaptic terminal which then fuse with the membrane. It then discharge contents into _______ via ________

Answer 1

Voltage-gated Ca++, Ca++; neurotransmitter vesicle; synaptic cleft, exocytosis

Question 2

Vesicles or pockets of ACh is called _____ and the process of release is called

Answer 2

Quanta, Quantal release of neurotransmitter

Question 3

During event at synaptic cleft, ACh diffuse from ______ and binds to _____ which is hydrolyzed by ______.

Answer 3

Synaptic cleft; Postsynaptic terminal; AChE

Question 4

During the events at ______, ACh binds to _____ which opens and allow _____ influx producing rapid local depolarization called ________

Answer 4

End plate; AChR; Na+, End plate potential (EPP)

Question 5

Each quantum of ACh produces small depolarization of muscle called

Answer 5

Miniature end-plate potential

Question 6

Depolarization from many quanta summate into full EPP which reaches threshold that open _____ channel resulting into ______

Answer 6

Voltage-gated Na+; AP

Question 7

AP propagates into _____ and ____ reaching the _______. This activates ______ channel releasing _____ from _____ into the cytosol of myocytes

Answer 7

Sarcolemma, T-tubules; voltage-gated Ca2+, Ca2+; sarcoplasmic reticulum (SR)

Question 8

Action of ACh is terminated leading to closure of ion channels, cessation of ______. At the same time, ______ channels open and allow ____ to move out, back to resting stage

Answer 8

EPP; voltage-gated K+, K+

Question 9

_____ is taken up by presynaptic terminal to be reused for synthesis of new ACh

Answer 9

Choline