local anaesthetics

Question 1

Percentage of protein bindings of LA in decreasing order

Answer 1

levobupi 97 > bupiv 95 > Ropiv 94 > ligno 70 > prilocaine 55 > procaine 6

Question 2

lignocaine

Answer 2

-amide local anaesthetic agent, composed of a lipophilic aromatic group and a hydrophilic amine group joined by an amide link (NH-CO)
-Local anaesthetic agents act on the intracellular portion of the voltage-gated sodium channel where a blockade prevents the spread of action potentials in excitable cells

Question 3

special about lignocaine

Answer 3

-Lignocaine has both local anaesthetic and anti-arrhythmic properties.
- Lignocaine is a class 1b anti-arrhythmic agent, blocking the voltage-gated sodium channel in the cardiac cell.
-Class 1b agents shorten the repolarization phase of the action potential, reducing re-entry phenomena, and are used for their membrane stabilizing effects in the management of ventricular arrhythmias.