23 - Orofacial granulomatosis Flashcards
1
Q
Define angio-oedema.
A
Oedema of the oral and facial soft tissues due to an increase in fluid exudate from the capillaries with no lymphatic drainage
2
Q
What other systemic conditions can present with angio-oedema?
A
- sarcoidosis
- tuberculosis
- Crohn’s
3
Q
What type of hypersensitivity is OFG?
A
Type 4
4
Q
What are multinuclear giant cells?
A
Macrophages fuse together after trying (and failing) to phagocytose an allergen to form a MGC
5
Q
What is an exclusion diet?
A
- avoidance of all foods that are allergens
- complete compliance is required
- usually for 3 months but benefits can be seen earlier
- reintroduce foods to identify triggers
6
Q
What systemic immune modulation can be used for treatment of OFG?
A
- pulsed azithromycin for 3 months
- prednisolone pulse for short term
