Lecture 07-08

Question 1

what are the function of benzos classified as

Answer 1

positive allosteric modulation of GABAa receptors (ligand-gated chloride ion channels)
hyperpolirizes the memrane, makes it harder to fire

Question 2

pharmacodynamics

Answer 2

study of the effect of drugs on the body (ex. sleepiness, kills bacteria)

Question 3

Benzo postive effects

Answer 3

sedation,sleep induction, anticonvulsant, muscle relaxtion, general reduction of signal transmission

Question 4

efficacy of benzos

Answer 4

reduced anxiety symptoms in first two weeks , but no long term benefit

Question 5

adverse benzo effects

Answer 5

drowziness, lack of coordination, concentration, decreased libido, ED, depression, disihnhintion, hypotension

Question 6

How does the tolerances of benzos work

Answer 6

overtime the body will notice the high levels of GABAa receptors working and will modify gene expression to stop producing as many receptors, which thus causes a result ina. reduction of overall Chlorine channel openings

Question 7

benzo withdrawl

Answer 7

due to tolerance issues overtime, benzos are needed to maintain and keep the same level, less inhintion of anxiety-evoking thoughts and events

Question 8

Long term side effects of benzos

Answer 8

greater than two weeks,
Cogntive impairment, inc anxi/depression, anhedonia, altered perception of self/relationships

Question 9

When are benzos prescibed?

Answer 9

gen anxiety/social anxiety disorder
usually reserved for pateints that have not responded to three treatemnts
acute emotional trauma, PTSD

Question 10

How do barbiturates work

Answer 10

Posituve allosteric modualtion of GABAa, with additional antagonism of NMDA NA+ channels
at high doses can stimulate GABAa recptors directly

Question 11

History of barbiturates

Answer 11

seen as huge breakthrough for anxiety and seizures, extremely addictive and fatal.