14 - CNS Flashcards
(10 cards)
1) LSD works on which receptors?
2) ANtidepressants work which receptors?
1) 5HT (serotonin) receptors
2) NA and 5HT receptors
Function of NA in CNS? (3 things)
- Arousal (amphetamines)
- Mood (Depression cured by NA reuptake inhibitors)
- BP regulation
1) Describe the pathways of Acetylcholine in CNS
2) Causes of alzheimers, parkinson’s, and huntingtons?
Either:
- Pons to thalamus + cortex
- Magnocellular forebrain nucleus to cortex
- Septohipoocampal.
- Magnocullular forebrain nuclei degeneration = Alzhiemers
- Corpus straitum interneurons = Parkinson’s + Huntington’s
Descrine ACh effects in CNS
- Aoursal and attention
- Leanring + memory (AChE inhibitors treat Alzheimer’s and Anticholinergic causes amnesia)
- Motor control (anticholinergics treats parkinsons)
Describe dopaminergic pathways in CNS
Either:
- Nigrostriatal – Regulate motor control (Most of DA in brain)
- Mesolimbic/mesocortical - emotion + rewards
- Tubero-hypophyseal – Regulate secretions (hypothalamus to pituitary gland)
Dopamine functions?
- Secretions (DA inhibits secretions, can be used to treat mother’s who don’t need to lactate anymore)
- Emotions + rewards (DA antagonist = antipsychotics)
- Motor control (L-Dopa is DA agonist)
- Vomiting (DA antagonist inhibits vomiting)
Describe Serotonergic pathways in CNS
SImilar to NA, Cell bodies in pons + upper medulla near raphe (so called raphe nuclei). Project to cortex, limbic, hypothalamus, and spinal cord.
Serotonin functions?
- Mood regulation
- Sleep regulation
- Apetite and digestion
- Cognition
- Pain perception
- Cardiovascular function
- Migraine regulation
1) GABA is excitatory/inhibitory?
2) Particularly abundant where?
1) Inhibitory
2) Nigrostriatal system
Describe GABA receptors.
Drugs Tx what?
GABA A – Postsynaptic ligand-gated ion channel:
- Diazepam = muscle relaxant
- Zopiclone = insomnia
- Pregabalin = anxiety
GABA B – GPCR (pre- and post-synaptic):
- Baclofen = Spasticity
