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DnD-Skin/Con/Misc > Pharma A/p/g/g > Flashcards

Pharma A/p/g/g Flashcards

1
Q

Medications that may trigger Psoriasis

A
  • Lithium
  • Beta-blockers
  • antimalarials
  • angiotensin-converting enzyme inhibitor
  • NSAIDs
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2
Q

Hydrating Agents

A
  • Water-in-oil prep
  • oatmeal products
  • ointments
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3
Q

Anti-pruitics

A
  • Antihistamines 1st Gen
  • Antidepressants
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4
Q

Calcineurin Inhibitors

A
  • Cyclosporine
  • Voclosporine
  • Tacrolimus
  • Pimecrolimus
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5
Q

Anti-TNF Drugs

A
  • Entanercept
  • Infliximab
  • Adalimumab
  • Certolizumab pegol
  • Golimumab
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6
Q

Cyclosporine

A
  • suppress t-cell activation
  • inhibit transcription of IL-2
  • inhibit production of cytokines
  • immunosuppression
  • Nephrotoxic, Cancer risk
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7
Q

Tazarotene

A
  • relative selectivity for RARb and RARg
  • inhibit keratinocyte proliferation and differentiation
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8
Q

Mycophenolate

A
  • inhibits inosine monophosphate dehydrogenase
  • inhibit proliferation of T- and B- lymphocytes
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9
Q

Calcipotriene

A
  • slows skin cell growth
  • synthetic vitamin D3
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10
Q

SE

Calcipotriene

A
  • skin irritation, sting, burn
  • Less common: dry skin, peeling, rash, dermatitis, worsening of psoriasis
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11
Q

Anthralin

A
  • reduces rapid growth of skin cells associated with plaque psoriasis
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12
Q

Alefacept

A
  • Binds to CD2 and inhibit leukocyte function antigen 3 and CD2 interaction
  • Prevent antigen binding and T-cell activation
  • Destroys T-lymph causing plaque
  • increase activity of NK cells
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13
Q

SE

Alefacept

A
  • Sore throat, dizziness, cough, nausea, itch, muscle pain, chill
  • injection site pain/ swelling
  • Serious: lymphopenia, infection, cancer, allergic rxn
  • Hepatic: elevate AST/ALT, fatty infiltrate, hepatitis
  • avoid if blood lymphocyte < 250/ml
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14
Q

IL-2

A

Necessary for T-cell activation

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15
Q

Calcineurin inhibitors

A
  • bind to immunophilins
  • blocks effect of calcineurin
  • leads to reduced IL-2 and T-cell prolif
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16
Q

Tacrolimus

A
  • indicated for moderate to severe atopic dermatitis
  • children > 2 y.o. (0.03%)
  • nephrotoxic, hemato/oncological
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17
Q

Pimecrolimus

A
  • mild atopic dermatitis
  • > 2 y.o.
  • Nephrotoxic, neospasms/infection
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18
Q

Acitretin

A
  • transcription regulator
  • reduce keratinocytes differentiation
  • slows cell reproduction
  • reduce epidermal hyperplasia
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19
Q

Target

TNF-alpha

A
  • Certolizumab pegol
  • entanercept
  • adalimumab
  • infliximab
  • golimumab
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20
Q

Target

IL-12 and 23

A

Ustekinumab

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21
Q

Target

IL-23

A
  • tildrakizumab
  • guselkumab
  • ## risankizumab
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22
Q

Target

IL-17

A
  • secukinumab
  • ixekizumab
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23
Q

SE

Ustekinumab

A
  • prevent T-cell activation
  • NVD, headache, tiredness
  • Upper resp. infection
  • flu symptoms
  • ulcer, syncope, body pain/swell
  • cerebal edema
  • allergic rxn
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24
Q

Interferon-gamma

A
  • produced by activated lymphocytes
  • antiviral activity
  • immunoregulatory fuction
  • In psoriasis, effects are absent
25
Q

IL-17

A
  • induced by IL-23
  • Pro-inflammatory cytokine
  • acts synergistically with TNF-a and IL-1
  • potent mediator in delayed-type rxn
  • recruits monocytes and neutrophils
26
Q

IL-17A blocker

Antibody that binds to inflammation-causing protein

A
  • ixekizumab
  • brodalumab
  • secukinumab
27
Q

IL-17A Blocker

Antibody against IL-17A

A
  • secukinumab
28
Q

Guselkumab

A
  • selectively inhibits IL-23
  • supress inflammatory and immune response
29
Q

SE

Guselkumab

A
  • NVD, headache, stomach flu
  • Upper resp. infection, fungal skin infection, herpes simplex infection
  • Inj site rxn
  • joint pain
30
Q

TYK2 Inhibitor

Deucravacitinib

A
  • selective to TYK2 pathway
  • fewer risks
  • inhibit immune response and inflammatory proteins
31
Q

SE

Deucravacitinib

A
  • NVD, fever, sweat, chill, muscle pain
  • SoB, stomach pain
  • Frequent/painful urination
  • Painful skin/ sores
32
Q

Inhibition of PDE4

A
  • increase cAMP, activate PKA
  • PKA inhibits Nuclear factor of activated cells
33
Q

Apremilast

A
  • PDE4 inhibitor
  • reduce TNF-a, upregulate IL-10
34
Q

SE

Apremilast

A
  • Headache, back pain, fatigue
  • NVD
  • URI, nasopharyngitis
  • serious: weight loss, severe NVD, depression, suicidal tendencies
35
Q

Medication that trigger acne

A
  • anabolic steroids
  • sex steroids
  • corticosteroids
  • Isoniazids
  • Lithium
  • Phenytoin
  • oral contraceptives
36
Q

Mild Acne

A
  • gentle cleanse
  • benzoyl peroxide
  • Low conc. SA
37
Q

Moderate- Severe Acne

A
  • Benzoyl peroxide
  • Draining large pimples
  • topical antibiotics
  • Retinoids
  • Azelaic acid
38
Q

Retinoic Acid

A
  • increase proliferation of cells
  • follicle epithelial turnover
  • decrease in microcomedones
  • shedding of corneocytes
39
Q

Topical Retinoid SE

A
  • dryness and irritation
  • skin color change
  • photosensitivity
  • red, swelling, crusting, blistering, eruptions
  • teratogenic
40
Q

Azelaic acid

A
  • treat rosacea and severe acne
  • competitive inhibitor of mitochondrial oxidoreductases
  • bacteriostatic
  • anti-keratinizing
41
Q

SE

Azelaic acid

A
  • burning feeling
  • peeling skin
  • dryness, redness
  • Rare: blister/flaking of skin, iriitation + swelling, tightness/pain in joints, hives, fever, difficulty breathing
42
Q

Dapsone

A
  • blocks complex that forms folate
  • decrease in folate availability
43
Q

Tetracycline

A
  • block access of amino TRNA complex
44
Q

Erythromycin / Azithromycin

A
  • blocks translocation
45
Q

SMTH-TMP

A
  • blocks PABA
46
Q

Clindamycin

A
  • Blocks peptide synthesis
47
Q

Gout

Probenecid SE

A
  • GI irritation
  • Allergic dermatitis
  • nephrotic syndrome
  • anemia
48
Q

Allopurinol SE

A
  • exacerbate acute gouty attack
  • GI distress
  • neuritis
  • hepatotoxic, interstitial nephritis
  • Rare: necrotising vasculitis, marrow depression, SJS, cataracts
49
Q

Febuxostat SE

A
  • NVD
  • rash
  • arthralgia
  • increased LFT’s
50
Q

Pegloticase SE

A
  • gout flare
  • nephrothiasis
  • NVD
  • rash
  • upper respiratory infection
  • dizziness, anemia, fatigue, hypertension
  • Delayed uticarial injection site rxn
51
Q

Lesinurad SE

A
  • NVD, headache, increased creatinine, GERD, influenza
  • BBW, risk of renal failure
52
Q

(-olol)

Beta-blockers SE

may develop tolerance

A
  • ocular stinging
  • redness, photophobia, dry eyes
  • uveitis
  • ocular inflammation
53
Q

Adrenergic agonist (epinephrine, dipivifrin)

A
  • headache, tachycardia, arrythmias
  • HTN,
  • anxiety, tremor, sweating nervousness
54
Q

ALPHA 2 ADRENERGIC AGONIST

Apraclonidine
Brimonidine

A
  • dryness
  • ocular irritation
  • headache, fatigue, sedation
  • Risk: dizziness, Hypotension
55
Q

(-zolamide)

Carbonic Anhydrase Inhibitor SE

A
  • NVD, metallic taste, cramps, GI distress
  • malaise, fatiue, weight loss,
  • decreased libido, anorexia
  • renal stone, renal failure, metabolic acidosis
  • depression, dementia
56
Q

Cholinergic Agonist

A
  • ocular (varied)
  • systemic: HTN, NVD, tachycardia, bronchospasm, pulmonary edema,
  • CI: asthma, retinal detachment, bradycardia, parkingson’s, heart failure, epilepsy
57
Q

(-prost)

Prostaglandin Analogs SE

A
  • mild burning, hyperemia, itching
  • blurred vision, eye pain/discomfort
  • Darker eye pigmentation
  • thicker eyelashes
58
Q

Lanoprostene Bunod

A
  • eye redness + discharge, eye irritation, eye pain
  • change in lashes, pain upon instilling drops

DnD-Skin/Con/Misc (5 decks)

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