Cardiac (HTN & Dysplipidemia) - MIDTERM Flashcards

1
Q

How is the SPIN and SNOUT acronym work for sensitivity/specificity?

A

Sensitive test when Negative rules OUT the disease’,

SPIN for, ‘Specific test when Positive rules IN the disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

For someone with diabetes, what in office BP measurements would indicate a diagnosis of HTN?

A

Diagnosis is recommended by OBPM ≥ 130/80 mmHg for > 3 measurements on different days. On the guideline this indicates PROBABLE HTN and you should get them to complete out-of-office BP monitoring to rule out whitecoat HTN.

evidence for defining AOBP and out-of-office (ABPM and HBPM) diagnostic thresholds is lacking (so just use same parameters as for those with nondiabetes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

A mean office BP of what value leads to automatic diagnosis with HTN?

A

> 180/110 (or hypertensive emergency)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

For a patient without diabetes, what values of AOBP or OBPM will lead you to take out-of-office BP measurements?

A

AOBP (preferred) ≥ 135/85

Or OBPM ≥140/90 (if AOBP not available)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What ABPM and HBPM Series mean values lead to diagnosis of HTN?

A

ABPM (preferred)
Daytime mean ≥ 135/85
24 hour mean ≥130/80

HBPM Series mean ≥ 135/85

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Your patient comes to your clinic and their OBPM is 145/98. What do you do next?

A

Assessment: History
Physical examination
Diagnostic tests for target organ damage (if clinically indicated)
CV Risk factors

Get them to complete out of office (either ambulatory BP monitoring or home BP series)

If these are elevated, can then diagnose with HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ABPM

A

Ambulatory Blood Pressure Monitoring requires the use of
a validated oscillometric device which must be worn by the
patient for a 24-hour period, with measurements taken at 20-
to 30-minute intervals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What occurs in an AOBP

A

Automated Office Blood Pressure is performed using an
automated device that can take a series of oscillometric
measurements without the provider or others present.
The patient is left unattended in a private area while
3-6 oscillometric, consecutive readings are taken.

(Preferred method for in office BPs)
If AOBP ≥ 135/85, send for out of office measurements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

HBPM

A

Two readings taken each morning and evening
for 7 days (28 total). Discard first day readings and average the
last 6 days.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Do we need to take a BP on both arms?

A

BP should be taken in both arms on at
least one visit and if one arm has a consistently higher pressure, that
arm should be used for BP measurement and interpretation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

OBPM. How many do you take? Which do you average?

A

Do at least 3 readings. The first reading should be discarded and the rest averaged

if OBPM≥140/90, send for out of office measurements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

If you don’t have an at out of office BP monitoring option, what do you do?

A

Serial office measurements over 3-5 visits can be used if ABPM
or HBPM are not available

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

You diagnose your patient with HTN. What preliminary tests will you order?

A

1.Urinalysis
2. Blood chemistry (potassium, sodium and creatinine)
3. Fasting blood glucose and/or glycated hemoglobin (A1c)
4. Serum total cholesterol, low-density lipoprotein (LDL), high-density
lipoprotein (HDL), non-HDL cholesterol, and triglycerides; lipids may
be drawn fasting or non-fasting
5. Standard 12-lead ECG

Routine testing of microalbuminuria in patients with hypertension without
diabetes or renal disease is not supported by current evidence.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Your patient is a 32 year old cis female. You diagnose her with HTN. What is a super duper important thing you need to rule out before initiating healthy behavior changes or antihypertensives?

A

Preggo!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the BP goal for a person with diabetes?

A

130/80

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Hypertension Canada stratifies patients by cardiovascular risk and, based
on that risk, there are different thresholds and targets for treatment.

What is the target BP for someone considered HIGH risk?

A

SBP <120

(this is on page 14 of the HTN Canada quick reference guide and seems weird to me, especially given that one of the high risk indicators is >75yrs old (and that seems like a low BP target to me for someone that old?)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

BP target for low and moderate risk individuals (moderate = TOD or CV risk factors)

A

<140/90

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Exercise recommendation for lowering BP according to HTN canada?

A

An accumulation of 30-60 minutes of dynamic
exercise of moderate intensity (such as walking,
cycling, swimming) 4-7 days per week in addition
to the routine activities of daily living. Higher
intensities of exercise are no more effective at
BP lowering.

(recommended to both hypertensive and normotensive individuals)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What measurements of weight are recommended for person to help reduce BP?

A

A healthy BMI (18.5 – 24.9 kg/m²)

waist circumference (<102 cm for men and <88 cm for
women) is recommended for non-hypertensive
individuals to prevent hypertension and for
hypertensive patients to reduce BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Recommended EtOH intake for person with HTN?

A

None! But if you must…

Patients with hypertension should abstain from, or
limit alcohol consumption to <2 drinks per day to
lower blood pressure.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What role does dietary potassium have on BP

A

More K+ = reduced BP

22
Q

What diet is recommended to lower BP?

A

DASH-like diet:
* High in fresh fruits, vegetables, dietary fibre,
non-animal protein (e.g., soy) and low-fat
dairy products. Low in saturated fat and
cholesterol.
* To decrease BP in hypertensive patients,
consider increasing dietary potassium

23
Q

Other important nonpharm treatments of HTN?

A
  • Smoking cessation
  • Relaxation therapies
24
Q

β-blockers are not indicated as first-line therapy for age ____ and above

A

60

25
Q

What are the generally recommended single pill combo meds for HTN?

A

ACE-I with CCB
ARB with a CCB,

ACE-I or ARB with a diuretic

26
Q

benefits of single pill combination therapy for HTN?

A
  • less pills to take
  • Low doses of multiple drugs
    may be more effective and
    better tolerated than higher
    doses of fewer drugs
  • Multiple drugs are often
    required to reach target levels,
    especially in patients with
    Type 2 diabetes
27
Q

You should reassess a patient with uncontrolled HTN at least every _____?

A

2 months

28
Q

T/F It’s okay to combine an ACE and ARB

A

False

29
Q

Consider referral to a
hypertension specialist if
BP is still not controlled
after treatment with ___
antihypertensive medications

A

3

30
Q

Which antihypertensives are recommended as first line agents for those with DM?

A

ACEI or ARB (with microvascular changes)

dihydropyridine CCBS and thiazide/thiazide-like diuretics

31
Q

What HTN meds are first line for someone with recent MI or heart failure?

A

ß-blockers and ACE inhibitors
(ARBs if ACE inhibitor intolerant)

32
Q

1st line HTN meds for someone with CAD?

A

ACE inhibitors or ARBs

β-blockers or CCBs for
patients with stable angina

33
Q

What antihypertensive should NOT be used in someone with heart failure?

A

Non-dihydropyridine CCBs (diltiazem & verapamil) (due to negative inotropic effects)

34
Q

1st line HTN meds in pregnancy & breastfeeding?

A

Labetalol, methyldopa and long-acting oral
nifedipine.

Other β-blockers (acebutolol, metoprolol,
pindolol and propranolol) can also be used.

35
Q

Contraindications for using beta blockers

A

severe asthma/COPD,
PAD;
2nd/3rd degree
heart block,
decompensated HF

36
Q

Contraindications for ACEI’s & ARBs

A

artery stenosis (solitary kidney or bilateral),
hx angioedema,
pregnancy

37
Q

Should HTN meds be taken in the morning or at night?

A

Recommend patients to
take their blood pressure pills at a time that optimizes adherence.

Consider bedtime dosing if patients are lightheaded or dizzy during the day; alternatively, consider morning dosing if
patients are at risk of overnight falls.

38
Q

Who to screen for dyslipidemia?

A

Men 40 years of age or older; women 40 years of age or older (or postmenopausal)

  • Consider earlier in ethnic groups at increased risk such as South Asian or indigenous individuals

All patients with any of the following conditions, regardless of age

  • Clinical evidence of atherosclerosis
  • Abdominal aortic aneurysm
  • Diabetes mellitus
  • Arterial hypertension
  • Current cigarette smoking
  • Stigmata of dyslipidemia (corneal arcus, xanthelasma, xanthoma)
  • Family history of premature CVD*
  • Family history of dyslipidemia
  • CKD (eGFR ≤ 60 mL/min/1.73 m2 or ACR ≥ 3 mg/mmol)
  • Obesity (BMI ≥ 30)
  • Inflammatory diseases (RA, SLE, PsA, AS, IBD)
  • HIV infection
  • Erectile dysfunction
  • COPD
  • History of hypertensive disorder of pregnancy
39
Q

You screen your patient for dyslipidemia and complete a Framingham risk scale. They are calculated to be low risk (<10%). DO you start them on a statin? What treatment will you recommend?

A

No, generally not recommended for low risk.
Exceptions include high LDL-C (>5.0) and a couple of other modifiers….

Health behaviour modifications only: smoking cessation, diet, exercise (>150mins/week moderate to vigorous)

40
Q

What constitutes high risk on the Framingham

Is a statin indicated here?

A

> or equal to 20%

Yes, everyone in this category gets a statin

41
Q

What is intermediate risk? DO they get a statin?

A

10-19.9%

This is a much fussier category:

You DO prescribe in this category if
LDL-C>3.5 OR non-HDL-C >4.2 or ApoB > 1.05 OR
- men 50 or older & women 60 and older with 1 addition risk factor: low HDL-C, IFG, high waist circumference, smoker, HTN…

42
Q

LDL-C goal once on statin therapy for someone with Diabetes or CKD?

A

LDL-C < 2.0

43
Q

LDL-C goal once on statin therapy for someone with ASCVD?

A

1.8 or less

44
Q

If you are at the maximally tolerated statin dose and your patient’s LDL-C is still 2.0 or high, what next?

A

Consider add-on therapy (Ezetimibe if first line)

45
Q

What are the “statin indicated conditions”
(Perhaps a better list to memorize)

A

1) LDL 5.0 or greater
2) Most patients with diabetes (40 or older, or 30 and older with 15 or more year hx or diabetes, or presence of microvascular disease)
3) CKD (age 50 or older and eGFR <60 or ACR >3)
4) ASCVD: MI, ACS, stable angina, stroke, TIA, PAD, claudication, ABI <0.9, AAA

46
Q

When we screen for dyslipidemia, what tests do we do?

A
  • History and physical examination
  • Standard lipid profile: TC, LDL-C, HDL-C,
    non-HDL-C, TG
  • Fasting plasma glucose (FPG) or glycated
    hemoglobin (A1c)
  • eGFR
  • Lipoprotein(a)—once in patient’s lifetime, with initial screening
47
Q

Is fasting lipid bloodwork recommended?

A

No, but it does cause slight changes when they don’t fast
(my preceptor says she sees a significant enough difference that she gets her patients to fast)

48
Q

WHy do we test lipoprotein A?

A

Has strong association with ASCVD risk, helps to inform if we need to be more aggressive with treatments

49
Q

How often should a cardiovascular risk assessment be completed?

A

Every 5 years for 40-75 years

49
Q

What baseline labwork would you need to start on a statin? Monitoring after?

A

LFTs and LDL at baseline

  • LFT:0,3,6,12 months & annually if high dose, combo, at risk
  • LDL: initial non-fasting LDL, then as indicated (
    fasting lipids 4-12 weeks after statin initiation & dose adjustments, and q3-12months thereafter as needed)
49
Q

What kind of diet is recommended for improving CVD risk?

A

Mediterranean

50
Q
A