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Foundations 2 > Week 3 Questions > Flashcards

Week 3 Questions Flashcards

1
Q

Avotermin - a recombinant human transforming growth factor beta 3 was developed for treatment of:

a. Kelloids
b. Wound infection
c. Scars

A

c. Scars

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2
Q

OSU8-1 is associated with one of the following:

a. TGF-Beta activation
b. HB-EGF shedding
c. EGF binding
d. Epigen shedding

A

b. HB-EGF shedding

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3
Q

Which of the following molecules can be phosphorylated by active TGF-Beta-1 binding to TGF-Beta-R?

a. Stat
b. MAPK
c. Smads
d. ERK

A

c. Smads

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4
Q

Topical becaplermin contains:

a. Recombinant EGF
b. Recombinant PDGF
c. Recombinant VEGF
d. Recombinant HGF

A

b. Recombinant PDGF

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5
Q

EGF has been implicated in:

a. monocyte recruitment
b. macrophage function
c. angiogenesis
d. keratinocyte migration

A

d. keratinocyte migration

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6
Q

What are growth factors?

a. Phosphoproteins that are involved in cell communication
b. Polypeptides that stimulate proliferation and migration
c. Glycoproteins that can promote growth
d. Lipoproteins involved in cell signaling

A

b. Polypeptides that stimulate proliferation and migration

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7
Q

Which cells primarily produce PDGF at wound site and a what phase of healing?

a. Endothelial cells during angiogenesis
b. Platelets at remodeling phase
c. Platelet degranulation at hemostasis
d. Fibroblasts during proliferative phase

A

c. Platelet degranulation at hemostasis

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8
Q

Topical VEGF therapy accelerates wound healing in experimental diabetic wounds?

a. True
b. False

A

a. True

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9
Q

Which of these is not an EGF family of mitogens? a. Epigen

b. HB-EGF
c. HGF
d. TFG-alpha

A

c. HGF

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10
Q

Latency-associated peptide bound TGF-Beta is inactive

a. True
b. False

A

a. True

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11
Q

Which one of the following is a biosynthetic precursor of elastin?

a. Proelastin
b. Tropoelastin
c. Heteroelastin
d. Elastase

A

b. Tropoelastin

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12
Q

MMPs are counteracted by

a. Tissue inhibitors of metalloproteinases
b. Matrix metalloproteinases
c. Proteases
d. Phosphatases

A

a. Tissue inhibitors of metalloproteinases

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13
Q

The polypeptide chains in collagen are arranged in a _____ helix.

a. Double
b. Triple
c. Quadruple

A

b. triple

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14
Q

Collagen can be cleaved by:

a. MMP-12
b. MMP-2
c. MMP-1

A

c. MMP-1

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15
Q

Hyaluronan is a:

a. Lipid
b. Polypeptide
c. ECM

A

c. ECM - Hyaluronan is a GAG, a soluble component of the ECM.

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16
Q

Which one of the choices is correct for ECM function?

a. Embryonic development
b. Progenitor cell recruitment
c. Cell death
d. Augment inflammation

A

a. Embryonic development

17
Q

Which is one of the smallest proteoglycans found in the ECM?

a. Aggrecan
b. Decorin
c. Hyaluronan

A

b. Decorin

18
Q

Which one is a predominant cell type that secretes abundant ECM?

a. Monocytes
b. Endothelial cells
c. Fibroblasts
d. Macrophages

A

c. Fibroblasts

19
Q

The following laminin is deposited as a part of a provisional matrix during wound healing

a. Laminin-331
b. Laminin-231
c. Laminin-233
d. Laminin-322

A

d. Laminin-322

20
Q

The following is one of the soluble components of the ECM.

a. Fibronectin
b. Proteoglycan
c. Collagen
d. Elastin

A

b. Proteoglycan

21
Q

How does X inactivation affect women who carry an abnormal gene on one X chromosome?

a. Extend of phenotype determined by distribution of mosaicism
b. No effect
c. Phenotype same as males with X-linked recessive disorder
d. Unable to pass abnormal gene to offspring

A

a. Extend of phenotype determined by distribution of mosaicism. Can have a lot of cells that carry mutation on active X chromosome –> worse symptoms.

22
Q

Which of the following statements is FALSE:

a. A contusion is a bruise without a break in the skin.
b. An abrasion is a superficial removal of skin.
c. An avulsion refers to tissues torn off partially or fully.
d. A laceration refers to intact skin over a crush injury.

A

d. A laceration is an injury where tissue is cut or torn.

Foundations 2 (5 decks)

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