Angiotensin Converting Enzyme Inhibitors (ACEI)

Question 1

T/F All ACE inhibitors end with -pril.

Answer 1

True

Question 2

Explain the Renin-Angiotensin-Aldosterone System

Answer 2

1. Blood volume low
2. Renin secreted from kidneys -> Renin in plasma
3. Renin converts Angiotensinogen to Angiotensin 1
4. Angiotensin 1 is converted to Angiotensin 2 via ACE in lungs
5. Angiotensin 2 is a powerful vasoconstrictor

Question 3

Angiotensin 2 acts on what two receptors?

Answer 3

AT I-R and AT II-R

Question 4

What is a common adverse effect of ACE inhibitors?

Answer 4

Dry cough

Question 5

Dry cough is an adverse effect of ACE inhibitors. What is the cause?

Answer 5

Increased bradykinin

Due to blockage of ACE (ACE normally functions to metabolize bradykinin because it is a vasodilator)

Question 6

What are the adverse effects of ACE inhibitors?

Answer 6

1. Dry cough
2. Angioedema
3. Tetrogenic
4. Glossitis
5. Altered taste (zinc)

Question 7

What is a common drug interaction with ACE inhibitors?

Answer 7

K-sparing diuretics

Question 8

What is the main action of the ACE inhibitors?

Answer 8

ACE inhibitors deactivate angiotensin-converting enzyme in the lungs (responsible for converting angiotensin 1 to angiotensin 2 (vaso-active)

Question 9

What do ACE inhibitors treat?

Answer 9

Hypertension and heart failure

Question 10

Name two common ACE inhibitors.

Answer 10

1. Captopril

2. Lisinopril

Question 11

This drug is also an ACE inhibitor (prodrug), but is used IV in cases of emergency HT?

Answer 11

Enalapril

Question 12

Both captopril and lisinopril are ACE inhibitors that treat hypertension. How do they work?

Answer 12

Dec ACE -> Dec AT-II action -> Dec TPR