NS: Migraines Flashcards

1
Q

What NSAID is licensed specifically for the treatment of an acute attack of migraine?

A

Tolfenamic.

Diclofenac, flurbiprofen + ibuprofen are also licensed for use in migraine.

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2
Q

The triptans work on what receptors?

A

5HT1B/1D.

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3
Q

The 5HT1-receptor agonists available for treating migraine are almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan.

Which of these are aso used to treat cluster headache?

A

Sumatriptan and zolmitriptan

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4
Q

Antiemetics, such as metoclopramide hydrochloride or domperidone, or phenothiazine and antihistamine antiemetics, relieve the nausea associated with migraine attacks.

Metoclopramide and domperidone have what added advantages?

A

They promote gastric emptying and normal peristalsis; a single dose should be given at the onset of symptoms.

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5
Q

The beta-blockers propranolol, atenolol, metoprolol, nadaolol, timolol are all effective for migraine prophylaxis, what is most commonly used?

A

Propranolol

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6
Q

Pizotifen is an antihistamine and a serotonin-antagonist which has limited use in migraine prophylaxis. What is it structurally related to?

A

TCA

Can cause weight gain.

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7
Q

Cluster headache rarely responds to standard analgesics.

What is the treatment of choice of cluster headache?

A

Sumatriptan by subcutaneous injection.

If injection is unsuitable, sumatriptan nasal spray or zolmitriptan nasal spray may be used.

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8
Q

What can be used for the prophylaxis of cluster headaches? (3)

A
  1. Verpamil
  2. Lithium
  3. Prednisolone
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