Degenerative Joint Disease

Question 1

define degenerative joint disease

Answer 1

chronic inflammatory arthritis w/i TMJ resulting in degradation of articular cartilage w/ remodeling of the subcondral bone

Question 2

what causes non-inflammatory degenerative joint disease aka osteoarthritis?

Answer 2

imbalance btwn catabolic and anabolic processes causing expression of catabolic cytokines.

Question 3

what 3 catabolic cytokines are expressed in osteoarthritis?
what do they cause?

Answer 3

-TNF alpha
-IL-I
-IL-6
-liberation of collagenases and proteases that result in degradation of the articular cartilage

Question 4

what is inflammatory arthritis?

Answer 4

joint destruction due to an inflammatory arthritic process
-rheumatoid arthritis
-juvenile rheumatoid arthritis
-psoriatic arthritis
-gout
-pseudogout
-ankylosing spondylitis
-reactive arthritis

Question 5

Treatment of degenerative joint disease

Answer 5

-depends on extent and level of life disruption
-medications
physical therapy
steroids
disease-modifying drug

Question 6

tx mild case of degenerative joint disease that failed conservative tx

Answer 6

arthrocentesis
arthroscopic procedures

Question 7

tx for advanced cases of degenerative joint disease

Answer 7

arthroplasty
total joint replacement