clinical research Flashcards

1
Q

GI structures (8)

A

oesophagus, stomach, duodenum, ileum, jejunum, ascending colon, transverse colon, descending colon

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2
Q

primary germ layers (3)

A

endoderm, mesoderm, ectoderm

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3
Q

endoderm becomes (2)

A

epithelium and associated glands

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4
Q

mesoderm becomes (4)

A

mesentery, connective tissue, smooth muscle, blood vessels

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5
Q

another name for mesoderm cells

A

splanchnic

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6
Q

ectoderm becomes

A

enteric nervous system

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7
Q

another name for ectoderm cells

A

neural crest cells

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8
Q

GI tract layers (5)

A

submucosa, submucosal plexus, circular muscle, myenteric plexus, longitudinal muscle

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9
Q

mouth salivary enzymes function (2)

A

carbohydrate breakdown and start digestion

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10
Q

salivary glands role (3)

A

moisten food, lubricate food, commence digestion

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11
Q

salivary enzyme

A

amylase

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12
Q

pharynx role (2)

A

food to stomach and prervent choking

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13
Q

oeophagus role

A

food to stomach from mouth

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14
Q

stomach secretes (2)

A

gastric juices and hydrochloric acid

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15
Q

stomach role (4)

A

digest food, kill pathogens, store food, churn food

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16
Q

stomach enzyme to break down protein

A

pepsin

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17
Q

largest organ in the body

A

liver

18
Q

liver role (7)

A

produce bile, food into energy, clear alcohol, clear some medicines, clear poison from blood, store vitamin and iron, destroy old blood cells

19
Q

bile (2)

A

breaksdown fat and removes waste from body

20
Q

gallbladder role

A

bile storage

21
Q

gallbladder secretes bile into

A

small intestine

22
Q

where can stones form

A

gallbladder

23
Q

pancreas role (3)

A

digestive enzyme production, bicarbonate production to neutralise stomach acid, insulin production

24
Q

what does nuerourology study

A

dysregulation and injury/degenerration

25
Q

what can dysregulate the urinary system (7)

A

overactive, underactive bladder, chronic inflammation, urinary incontinence, retention, visceral and pelvic pain, ageing

26
Q

what can cause urinary injury and degeneration (7)

A

pelvic surrgery, spinal cord injuries/neurogenic bladder, diabetic neuropathy, stoke, MS, parkinsons, alzeihmers

27
Q

sub topics of neurourology (5)

A

neural origin, neural contributors, symptoms, progression, solutions

28
Q

teams that works with neurourology (6)

A

urology, gynecology, neurology, immunology, neurobiology, engineering

29
Q

scope of challenge (4)

A

brain, spinal cord, sensory and autonomic ganglia, nerve genitourinary organ interface

30
Q

what types of disease has vagal neuromodulation been used for (6)

A

cardiac, immune, metabolic, CNS, GI, respiratory

31
Q

immune diseases using vagal neuromodulation (2)

A

Crohn’s and RA

32
Q

metabolic diseases using vagal neuromodulation (2)

A

obesity and T2D

33
Q

CNS diseases using vagal neuromodulation (3)

A

epilepsy, depression, migraines

34
Q

SPARC

A

stimulating peripheral activity to relieve conditions

35
Q

what does SPARC use (5)

A

neural maps, computational models, electrode design, stimulation protocols, surgical methods

36
Q

what does the pelvic nerve supply (2)

A

majority of lower urinary tract and multiple organs

37
Q

LUT

A

lower urinary tract

38
Q

pelvic nerve human analogue

A

pelvic splanchnic nerve

39
Q

pelvic nerve speecifically supplies (4)

A

bladder contractions, urethra relaxation, mechanosensors, nociceptors

40
Q

what does multi scale mapping do (4)

A

cell to organ structure and function, comparing biological life cycles, cross species harmonisation, micro to macro

41
Q

underlying reference map contextualising new samples

A

common coordinate framework

42
Q

complete map of neural connections

A

connectome