lecture 5 - cancer genetics

Question 1

What are the 2 most common high penetrance familial breast-ovarian cancer genes?

Answer 1

BRCA1, BRCA2

Question 2

What is Lynch Syndrome?

Answer 2

A genetic condition caused by one of a few gene mutations (MLH1, MSH2, etc.) that dramatically increases the risk of developing colorectal cancer

Question 3

What are some of the management strategies for patients with a known genetic predisposition to cancer?

Answer 3

Surveillance, prophylactic surgery, chemoprevention drugs, pre-implantation genetic screening/IVF