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Pharmacie Automne 2023 > Examen cardio 1 > Flashcards

Examen cardio 1 Flashcards

1
Q

caractéristiques des facteurs de risque

A

démographique
psychologique
anatomique
physiologique

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2
Q

mode action niacine

A

inhibition lipolyse (diminution AGL)
inhibition DGAT2 -> PreB HDL utiliser pour transport inverse

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3
Q

métabolisme ezetimibe

A

métabolite actif glucoronide
plus actif que rx
cycle entéro-hépatique durée de vie + longue

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4
Q

étape siRNA

A

association RISC pour former nucléase
double brin -> simple
simple + ARNm
ARNm dégrader par nucléase

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5
Q

cible case verte (familiale)

A

2.5
0.85
3.2

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6
Q

obésité viscérale conséquences

A

intolérance glucose
PA

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7
Q

CI lomitapide

A

grossesse
MIC
IH
inhibiteur 3A4
simvastatine 40

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8
Q

métabolisme voie exogène

A

chylomicron
b48
rc LDL (apoB et E)

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9
Q

métabolisme voie endogène

A

cholestérol estérifié + TG dans VLDL
B100
devient IDL + LDL
rc LDL apoB

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10
Q

voyage inverse

A

ABCA1 formation HDL naissant
maturation via LCAT
retour direct ou retour indirect (CEPT)

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11
Q

Autres valeurs pertinentes

A

glycémie
TSH
ALT
créatinine sérique
hsCRP

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12
Q

interactions statine

A

colchicine
daptomycine
FES

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13
Q

interactions ezetimibe

A

cyclosporine
FES

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14
Q

interactions fibrate

A

warfarine
cyclosporine
FES
gem : substrat 2C

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15
Q

interactions résine

A

index étroit
autres rx pouvant nuire absorption

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16
Q

interactions niacine

A

warfarine
FES
vasodilatatrice, hypoglycémiant oral

17
Q

précaution et CI statine

A

IH
IR

18
Q

précaution et CI ezetimibe

A

IH

19
Q

précaution et CI fibrate

A

IH
IR
maladie biliaire

20
Q

précaution et CI résine

A

atrésie biliaire
HTG
maladie intestinale obstructive

21
Q

précaution et CI niacine

A

IR
maladie hépatique active
ulcère GI

22
Q

précaution et CI I PCSK9

A

IR sévère

23
Q

précaution et CI icosapent éthyl

A

IR
IH

24
Q
A

Pharmacie Automne 2023 (6 decks)

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