Autonomic Pharmacology

Question 1

Cholinergic receptors

Answer 1

Nicotinic & muscarinic

Question 2

Adrenergic receptors

Answer 2

alpha & beta

Question 3

Which receptors does the PSNS use

Answer 3

cholinergic & muscarinic

Question 4

receptors do the SNS use

Answer 4

adrenergic

Question 5

What do M1, M3, M5 receptors cause

Answer 5

G protein coupled activators –> cause contraction

Question 6

What do M2 & M4 receptors cause

Answer 6

inhibitory G protein couple receptors

Question 7

Cholinergic vs adrenergic in the heart

Answer 7

M2
Adrenergic - increase heart rate
Muscarinic - decrease heart rate

Question 8

Cholinergic vs adrenergic in the lungs

Answer 8

adrenergic - bronchodilation
cholinergic - bronchoconstriction

Question 9

Cholinergic vs adrenergic in the sphincters (GI & bladder)

Answer 9

Cholinergic - relaxation
sphincter - opens so you can pee

Question 10

Cholinergic vs adrenergic in the walls

Answer 10

contraction

Question 11

Cholinergic vs adrenergic in urination

Answer 11

M3 in bladder - contracts
M3 in sphincter - relaxes

Question 12

3 types of cholinergic drugs

Answer 12

1. Acetylation - rapid recovery, physiological
2. Carbamylation - slow recovery, reversible
3. phosphorylation - no recovery, ireversible

Question 13

What drug blocks PSNS responses

Answer 13

parasympatholytics

Question 14

how do parasympatholytics work

Answer 14

atropine - block the M receptors

Question 15

what effect (adverse & beneficial) does atropine have

Answer 15

beneficial - clear airways, dilate pupils, counteract poisoning by cholinesterase inhibitors
adverse - dry mouth, tachycardia, constipation, difficulty urinating

Question 16

what do alpha-1 receptors do

Answer 16

constrict smooth muscles

Question 17

where are alpha-1 receptors located

Answer 17

sphincters, blood vessels

Question 18

what do alpha-1 receptors do to blood vessels

Answer 18

vasoconstriction

Question 19

what do alpha-2 receptros do

Answer 19

inhibit presynaptic norepinephrine release

Question 20

what do beta-1 receptors do in the heart

Answer 20

stimulate the heart

Question 21

what do beta-1 receptors do in the kidney

Answer 21

stimulate renin release

Question 22

what do beta-2 receptors do

Answer 22

relax the smooth muscles

Question 23

where are beta-2 receptors located

Answer 23

lungs, blood vessels, spinchter

Question 24

what do beta-2 receptors cause in the lungs

Answer 24

bronchodilation

Question 25

what causes bronchodilation in the lungs

Answer 25

beta-2 receptors

Question 26

what does beta-2 receptors do in blood vessels

Answer 26

vasodilation

Question 27

what caues vasodilation

Answer 27

beta-2 receptors

Question 28

what causes vasoconstriction

Answer 28

alpha-1

Question 29

what does beta-2 receptors do in the GI tract, bladder & uterus

Answer 29

relaxation of walls

Question 30

what causes relaxation of walls in the GI tract, bladder & uterus

Answer 30

beta-2

Question 31

what does beta-2 receptors do in the liver

Answer 31

gluconeogenesis & glycogenolysis

Question 32

waht do sympathomimetics do

Answer 32

mimic stimulation of SNS

Question 33

what do sympatholytics do

Answer 33

block or reduce sympathetic activity

Question 34

Which receptors control the circular muscle and what do they do

Answer 34

M3 & M2 –> contracts constricts pupil

Question 35

which receptors control the radial muscle

Answer 35

alpha 1 -> contraction dilates pupil

Question 36

what is increased intraocular pressure

Answer 36

glaucoma