Endocrine Others

Question 1

Most common cause of Cushing syndrome

Answer 1

Iatrogenic

Question 2

Most common cause of primary hypoadrenalism (adrenal insufficiency)

Answer 2

Infectious disease

Question 3

Most common cause of secondary adrenal insufficiency

Answer 3

Due to ACTH deficiency, sudden cessation of exogenous glucocorticoid therapy

Question 4

Tests done to check for Cushing syndrome

Answer 4

• Mid night salivary cortisol
• 24 hours urinary free cortisol
• Overnight dexamethasone suppression test

Question 5

Investigation for cause of Cushing syndrome

Answer 5

• morning plasma ACTH
• imaging (pituitary or adrenals)

Question 6

Hormones secreted by anterior pituitary gland

Answer 6

ACTH
LH
FSH
Prolactin
GH
TSH

Question 7

Hormones secreted by posterior pituitary gland

Answer 7

Oxytocin
ADH (vasopressin)

Question 8

Most common pituitary tumor overall

Answer 8

Non functional tumors

Question 9

Most common functional pituitary tumor

Answer 9

Prolactinomas

Question 10

Imaging of choice for prolactinomas

Answer 10

MRI

Question 11

Gold standard investigation for Acromegaly

Answer 11

OGTT: Failure to suppress GH level to < 2mU/L after 75g glucose load

Question 12

Treatment of SIADH hyponatremia

Answer 12

Cautious correction by saline infusion. Rapid over correction leads to central pontine myelinosis