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Neuro II > CNS chemotherapy > Flashcards

CNS chemotherapy Flashcards

1
Q

PCV regimen for CNS cancers

A

Procarbazine
CCNU
Vincristine

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2
Q

Uses of temozolomide in CNS cancers

A

Anaplastic astrocytoma refractory to nitrosoureas

Glioblastoma multiforme

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3
Q

Single agent for adult glioblastoma multiforme in the setting of progressive disease following first-line chemotherapy

A

Bevacizumab

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4
Q

Adverse effects of bevacizumab

A

HTN
Bleeding

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5
Q

Mechanism of nitrosoureas

A

Act by cross-linking DNA, causing alkylation
Highly lipid soluble and able to cross BBB

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Neuro II (21 decks)

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