PHARMACOLOGY 2

Question 1

Numerate only Blood schizonticide drugs

Answer 1

1.Chloroquine
2.Quinine
3.Artemisinin (Rabidly acting blood schizonticidal)

Question 2

What is the mechanism of action of chloroquine

Answer 2

1.Inhibit parasite from hemoglobin digestion——-> decreasing nutrient amino acids for the parasite

2.Inhibit parasite heme polymerase——-> accumulation of toxic heme

Question 3

what are the therapeutic uses of chloroquine

Answer 3

1.Prophylaxis and treatment of chloroquine sensitive malaria ( followed by primaquine to eradicate dormant form—-> prevent relapse)

2. Amoebic hepatitis and amoebic liver abscess
3. Rheumatoid arthritis (anti-inflammatory effect)

Question 4

Adverse effects of chloroquine

Answer 4

1. Headache
2. C.V.S: hypotension and arrhythmia (quinidine like action)
3. GIT: Nausea, vomiting and diarrhea
4. Eye: corneal opacity——> blurred vision and retinopathy
5. Hemolytic anemia: in G6PD deficiency

Question 5

Quinine is

Answer 5

1. Absorbed well after oral administration
   2.interfere with heme polymerization——> death of RBCs
   3.used in chloroquine resistance falciparum
   4.weak muscle relaxant
   5. not used as prophylactic (too toxic)

Question 6

Adverse effects of quinine

Answer 6

1. Quinidine like reaction——>hypotension and arrhythmia
2. Eye: blurred vision and blindness
3. cinchonism: tinnitus, headache, dizziness & visual disturbance
4. Black water fever and hemolysis
5. Oxytocic on uterus——> abortion