schizophrenia other biological explanation

Question 1

how many people with a first degree relative develop Sz

Answer 1

10%

Question 2

how many people develop Sz with a second degree relative

Answer 2

2-6%

Question 3

how many people with a MZ twin develop Sz

Answer 3

40-65%

Question 4

what concordance rate with MZ did Gottesman and shields find

Answer 4

38%

Question 5

why are genes linked to scizophrenia complex to understand

Answer 5

less than 1/3 of schizophrenics have family history
complex
no single gene has been identified

Question 6

name 3 genes linked to Sz

Answer 6

22q11 - those with section missing show psychotic symptoms
fequency of Sz is 18%

DISC 1 - those with gene 1.4x more likely to develop
gene codes for GABA

Xq 23 region - gene varient
52% of schizophrenics have this

Question 7

what are the strengths of the gentic explanation

Answer 7

+ gottesman and shields compared MZ and DZ twins, comparing blood groups finger prints and facial alikeness, MZ concordance 42%
DZ 9%

+ gottesman and shields replicates ither studies, reliable

+ heston comapred children adopted at birth because mother had Sz with healthy children, 10% developed SZ

+ in a review of 14 studies Dahoun concluded the DISC 1 gene is associated with presynaptic dopamine dysregulation

Question 8

what are the weaknesses of the genetic explanation

Answer 8

• reductionist not focusing on the whole person
• gottesman and shields didnt find 100% concordance in MZ
• many people with Sz dont have family history and many with family hisorty dont have Sz
• Tiwaried mentioned other factors come from environment thay can affect mechanisms driven by genes

Question 9

what is the diathesis stress model

Answer 9

genes create vulnerability for Sz rather than causing it

triggered by other biological or environmental factors