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Farma > Parkinson > Flashcards

Parkinson Flashcards

1
Q

Principal pars afectada en el parkinson

A

Pars compacta

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2
Q

que vías estan afectadas en el parkinson?

A

las dopaminergicas

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3
Q

Los síntomas de rigidez y temblor en extremidades se deben a

A

Aumento en los niveles corticales de acetilcolina

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4
Q

tx primera línea para parkinson

A

Levodopa

atraviesa BHE

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5
Q

efectos secundarios levodopa

A

psicosis, alucinaciones y empeora sintomas motores

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6
Q

medicamento que se usa en conjunto con levodopa pero que no cruza la BHE

A

Carbidopa

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7
Q

mecanismo de acción carbidopa

A

inhibe dopa descarboxilasa

DOPA a dopamina

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8
Q

Inhibidores selectivos de la MAO también usados en tx depresión

A

Rosagilina
Selegilina

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9
Q

Cuando usamos inhibidores de la MAO?

A

en etapas tempranas

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10
Q

a que se degrada la selegilina?

A

a anfetaminas

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11
Q

Mecanismo de acción inhibidores de la COMT

A

inhiben sintesis de dopamina

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12
Q

cuando se usan mas los inhibidores de la COMT?

A

cuando levodopa produce complicaciones motoras

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13
Q

inhibidores de la COMT

A

Tolcapona
Entocapona

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14
Q

inhibidores de la COMT que atraviesan BHE

A

Tolcapona

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15
Q

inhibidores de la COMT que no atraviesan BHE

A

entocapona

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16
Q

efecto adverso tolcapona

cruza BHE

A

hepatoxicidad
hipotensión ortostatica
inhibe levodopa

17
Q

Agonistas receptores D2 like

Gs

A

se usan en px menores de 65 años o cuando levodopa pierde efecto

18
Q

Agonistas receptores D2 like

efectos adversos?

A
  • Bromocriptina
  • Pramipexol
  • Ropinirol

Prami y Ropi: somnolencia

bromocriptina: fibrosis pulmonar

19
Q

Amantadina

A

tiene efectos neuroprotectores , antes era un antiviral.
* Bloquea recaptura de dopamina

20
Q

Efectos adversos amantadina

A

Crisis aquinetica y sueños raros

21
Q

Anticolinérgicos

A

equilibran DA y Ach
* bloquean receptores muscarinicos

22
Q

Anticolinérgicos

A
  • benzatropina
  • Trihexifenidilo
23
Q

Tx parkinson

A
  • Levodopa+carbidopa
  • Inhibidores de la MAOB
  • Inhibidores de la COMT
  • Agonistas de receptores D2-like
  • Amantadina
  • Anticolinergicos

Farma (10 decks)

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