Infection and Response Flashcards

1
Q

name the different pathogens

A

viruses, bacteria, protists and fungi

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2
Q

how are pathogens spread?

A
  • direct contact- can be sexual contact during intercourse or non-sexual contact, like shaking hands
  • water- dirty water can transmit many diseases
  • air- when an infected person sneezes, coughs etc., they can spray thousands of tiny droplets containing the pathogen to infect others.
  • unhygienic food preparation- undercooked or reheated food can cause bacterial diseases like escherichia coli which is a cause of food poisoning.
  • vector- any organism that can spread a disease is called a vector- any farmers think tuberculosis in their cattle can be spread by badgers
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3
Q

how do pathogenic bacteria and ciruses cause damage in the body?

A
  • viruses cause infections by entering and multiplying inside the host’s healthy cells
  • bacteria spread diseases by producing toxins which damage human tissues and make us feel ill
  • bacteria can cause disease by reproducing within the human body very quickly
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4
Q

how can the spread of disease be prevented?

A
  • sterilising water- e.g. cholera- chemicals or UV light kill pathogens in unclean water
  • suitable hygiene (food)- e.g.salmonella- cooking foods thoroughly and preparing them in hygienic conditions kills pathogens
  • suitable hygiene (personal)- e.g. athlete’s foot washing surfaces with disinfectants kills pathogens (treating existing cases of infection kills pathogens)
  • vaccination- e.g. measles- vaccinations introduce a small or weakened version of a pathogen into your body, and the immune system learns how to defend itself.
  • contraception- e.g. HIV/AIDs- using barrier contraception, like condoms, stops the transfer of bodily fluids and sexually transmitted diseases
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5
Q

describe measles and identify what type of pathogen it is

A
  • a very infectious viral disease
  • often caught by young children by transmition through the air in tiny droplets after an infected person sneezes
  • causes a fever and skin rash but can cause more serious effects like infertility in adults who did not catch the disease as children
  • children in developed countires are given vaccines but this isn’t available everywhere
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6
Q

describe HIV and identify what type of pathogen it is

A
  • virus/ viral pathogen
  • human immunodeficiency virus
  • transmitted by body fluids, often during unprotected sex, but also through cuts and injecting drugs using shared needles
  • suffer mild flu-like symptoms but these pass and infected may not realise they have it
  • months or years after the infection of the HIV virus, it becomes active and starts to attack the patient’s immune system, becoming AIDS
  • no cure but infected people are given antiviral drugs, which can slow the development of AIDS
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7
Q

describe tobacco mosaic virus and identify what type of pathogen it is

A
  • viral pathogen
  • infects the chloroplasts of plant leaves and changes their colour from green to yellow or white in a mosaic pattern
  • infects tobacco and other closely related species, such as tomatoes and peppers
  • transmitted by contact between plants, either naturally or through the hands of farmers
  • reduces the plant’s ability to photosynthesise and grow properly
  • no cure
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8
Q

describe salmonella and identify what type of pathogen it is

A
  • bacterial pathogen
  • causes food poisoning- abdominal cramps, vomiting and diarrhoea
  • caused by unhygienic kitchens, undercooked foods such as meat, eggs and poultry, or the same foods that have not been reheated properly
  • prevented by all poultry being vaccinated against it and cooking food thoroughly, after preparing it in hygienic conditions
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9
Q

describe gonorrhea and identify what type of pathogen it is

A
  • bacterial pathogen
  • sexually transmitted disease- burning pain when urinating and often forms a thick yellow or green
    discharge- can result in infertility
  • can be prevented by not engaging in sex or using contraception
  • treated by antibiotics
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10
Q

describe the signs, transmission and treatment of rose black spot and identify what type of pathogen it is

A
  • fungal pathogen
  • infects leaves and causes black or purple spots on the leaves and the rest of the leaves often turn yellow and can drop off the plant, reducing it’s ability to photosynthesise and therefore grow
  • transmitted in air or water, as well as through direct contact by gardeners
  • treatable using
    fungicides
    and by removing and destroying infected leaves
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11
Q

describe symptoms, transmission and treatment of malaria and identify what type of pathogen it is

A
  • protist pathogen
  • spread by mosquitos which carry the plasmodium protist- suck blood containing the protists from an infected person, passing the protist to other people they suck blood from
  • the mosquitos don’t become ill and are called vectors
  • symptoms of malaria include a fever, sweats and chills, headaches, vomiting and
    diarrhoea
  • no vaccination, prevented by sleeping under mosquito nets and wearing insect repellent to avoid bites, take antimalarial drugs which treat the symptoms and can prevent infection
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12
Q

describe defences that stop pathogens entering the human body

A
  • skin- covers almost all parts of your body, acting as a physical barrier, if it is cut it immediately heals itself and forms a scab
  • nose- internal hairs, which act as a physical barrier to infection and mucus produced traps pathogens before they can enter the lungs and when the nose is blown, mucus containing pathogens is removed
  • trachea/ windpipe- ciliated cells that line the trachea waft their hairs and move mucus and pathogens upwards towards the throat where it is swallowed into your stomach and gablet cells create the mucus- mucus in airways are a physical barrier
  • stomach- stomach (hydrochloric) acid kills any pathogens caught in the mucus in the airways or consumed in food/ water, it is a chemical barrier
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13
Q

how do white blood cells destroy pathogens?

A
  • two types: phagocytes and lymphocytes
  • phagocytes- attracted to and surround any pathogens in the blood and bind to and engulf them, breaking down and destroying them- phagocytosis
  • lymphocytes- detect that antigens are foreign and produce antibodies which cause pathogens to stick together and make it easier for phagocytes to engulf them. they also produce antitoxins to neutralise any toxins a pathogen might release
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14
Q

how does vaccination work, including at population level?

A
  • they allow a dead or altered form of the disease causing pathogen to be introduced into the body which stimulates the body to produce antibodies to provide immunity against that disease
  • herd immunity- the protection given to a population against an outbreak of a specific disease when a very high percentage of the population have been vaccinated against it
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15
Q

explain how antibiotics and painkillers are used to treat diseases and their limitations

A
  • antibiotics- substances that slow down or stop the growth of bacteria by damaging the bacterial cells but not the host cells which stops them reproducing and spreading
  • one antibiotic may only work against one or a few types of bacteria meaning a range is needed, theyonly cure bacterial diseases and not viral ones
  • painkillers- chemicals that relieve the symptoms but do not kill the pathogens
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16
Q

how have sources for drugs changed over time and give examples

A
  • certain drugs can be extracted from natural sources and have been for a long time
  • e.g. willow bark was used by the ancient Greeks to help cure fevers and pains
  • tt was later discovered that the active ingredient was salicylic acid which was modified by chemists into the substance we call aspirin, which is less irritating to the stomach than salicylic acid
  • another example is the heart drug, digitalis which is extracted from foxgloves
17
Q

how are new drugs tested?

A
  1. tested using computer models and skin cells grown using human stem cells in the laboratory, many fail because they damage the cells or do not work (pre-clinical)
  2. tested on animals- giving a known amount of the substance to the animals, then monitoring them carefully for any side-effects (pre-clinical)
  3. human clinical trials- tested in healthy volunteers to test safety and then on people with the illness to test safety and if it works
    * to reduce placebo effect in human clinical trials,
    * in blind trials only, the doctor knows which patients have been given the drug and which have been given the placebo
    * in double blind trials, neither the doctor nor the patient knows who has been given the drug or placebo
18
Q

what are monoclonal antibodies and why are they useful?

A
  • identical copies of an antibody produced by fusing a spleen cell with a cancerous white blood cell which can be designed to bind to many different substances
  • used for pregnancy tests, treatments for cancer, prevention of drug overdoses
19
Q

how are monoclonal antibodies produced?

A
  1. antigen we want the antibody for is injected into a mouse
  2. lymphocytes target the antigen
  3. spleen cells which produce the lymphocytes that produce the specific antibodies are removed
  4. the spleen cells are fused with human cancerous white blood cells to form hybridoma cells which are fast reproducing and make specific antibodies
  5. they are then cultured and multiplied to produce lots of monoclonal antibodies
20
Q

how are monoclonal antibodies used for diagnosis, research, chemical testing and disease treatments?

A
  • diagnosis- monoclonal antibodies can be designed to bind specifically with cancer cell antigens to clump them together and be identified as a cancerous tumour easier, monoclonal antibodies in pregnancy tests are designed to bind to hormone HCG which is only found in pregnant women so when she urinates, the HCG in her urine will bind to the monoclonal antibodies causing a colour change on the stick
  • research/ chemical testing- binding to hormones/ chemicals in blood to measure their levels, test blood samples in labs for certain pathogens, locating specific molecules in a cell or tissue
  • disease treatment- used to treat cancer by carrying drugs that have been attached to them, to the tumour and encouraging your immune system to attack the cancer cells directly
21
Q

advantages of monoclonal antibodies

A
  • testing for pregnancy
  • testing for diseases such herpes and chlamydia, and HIV which can lead to the development of AIDS
  • to treat conditions like cancer
  • can be produced quickly despite the fact that it can be time consuming when they are made for the first time
22
Q

disadvantages of monoclonal antibodies

A
  • unwanted side effects- fever, vomiting, low blood pressure
  • expensive to produce
  • ethical issues- people don’t think it’s right to use a mouse for producing monoclonal antibodies and in 2006, a drug trial involving monoclonal antibodies went wrong
23
Q

describe observable signs of plant disease

A
  • stunted growth
  • spots on leaves
  • decay/ dying
  • malformed stems/ leaves
  • discolouration
  • presence of pests (aphids)
24
Q

how can plant disease be identified?

A

plant disease can be identified by using books the internet, taking a small cutting of a plant to a local garden centre or for more difficult diseases, cuttings of the plant may be analysed by scientists in laboratories using testing kits containing monoclonal antibodies

25
Q

give examples of plant ion deficiencies and their effects

A
  • nitrates- needed to make proteins for growth
  • defficiency= reduces the chlorophyll level, reducing ability to photosynthesise= leaves turn pale yellow/ green and stunted growth
  • magnesium- needed for synthesis of chlorophyll which is needed for photosynthesis
  • defficiency= yellowing leaves and stunted growth
  • potassium- produces flowers/ fruit
  • defficiency= poor flower/ fruit growth, yellow leaves, dead spots
26
Q

describe physical, chemical and mechanical defence responses of plants

A
  • physical- thick bark, waxy cuticle on leaves
  • mechanical- thorns/ hairs protect from damage, drooping leaves when touched by insects to stop them feeding on leaves, mimicry
  • chemical- production of antibacterial chemicals, poisons to defend from herbivores rather than pathogens (e.g. stinging nettles)