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Immunology > 8. Cytokines > Flashcards

8. Cytokines Flashcards

1
Q

T and B cell proliferation?

A

IL-2

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2
Q

Causes B cells to make different antibodies

A

IL-4

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3
Q

INF-g used to treat?

A

chronic granulomatous disease

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4
Q

Mutations of what in IL-2 R lead to SCID

A

gamma chain

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5
Q

IFN-a used to treat?

A

HBV, HCV, HHV-8

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6
Q

IFN-B used to treat?

A

MS

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7
Q

IFN-g activates macrophages to stimulate? inhibit?

A

Intracellular killing

Th2 response

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8
Q

The Pyrogenic Cytokines?

A

IL-6, IL-1, TNF-a

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9
Q

TNF-alpha made by? Beta made by?

A

Alpha - macrophages, T cells, fibroblasts

Beta - T cells and B cells

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10
Q

Who induces the liver to make acute phase proteins? and induce febrile response?

A

IL-1 and IL-6 proinflammatory

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11
Q

Who stimulates hematopoiesis? acts on plasma cells to drive Ab production? isotype switching?

A

IL-6

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12
Q

Clinical use of IL-6 inhibitor?

A

MRA (anti-IL-6) to tx RA

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13
Q

IL-2 GO!

A

made by T cells - AUTOCRINE REGULATION

stim. growth/differentiation of T cells (Th/CTL), B cells, NK cells

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14
Q

Basiliximab and daclizumab?

A

blocks IL-2 signaling (derected toward alpha chain of IL-2R)
Increases success of organ transplants
Tx leukemia/melanomas (experimental)

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15
Q

IL-4 and IL-5 made by?

A

Th2 cells

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16
Q

Who promotes class switching from IgM to IgE and IgG

A

IL-4

17
Q

Who inhibits IFN-g production

A

IL-4

18
Q

Promotes switch to IgA (with TGF-B), induces eosinophil differentiation

A

IL-5

19
Q

Omalizumab, xolair?

A

monoclonal antibody against IL-4

used to treat serious allergies

20
Q

IL-10 GO!

A

promotes Th2 response (activates B cells)

down regulates pro inflammatory cytokine production, made in macrophages

21
Q

1st cytokine responsible for stimulating immune response?

A

IL-12

22
Q

Synergizes with IL-18 to induce IFN-g from Th1

A

IL-12

23
Q

Induces differentiation of Th cells to Th1 cells

A

IL-12

24
Q

Job of IL-8?

A

attract neutrophils to site of inflammation (chemokine/chemotaxis)

25
Q

IL-3 growth factor for? IL-7?

A

WBC

lymphocytes (B and T cells)

26
Q

growth factor for hematopoietic stem cells and granulocyte/monocytes?

A

GM-CSF

27
Q

M-CSF?

A

macrophage production

28
Q

growth factor essential for neutrophils?

A

G-CSF (granulocyte)

29
Q

growth factor for RBC?

A

Erythropoietin (EPO)

30
Q

Drug; leukine. cytokine? function?

A

GM-CSF; boost immunity during chemotherapy

31
Q

Drug: neupogen. cytokine? function?

A

G-CSF; boost immunity (neutrophils) prior to bone marrow transplant

32
Q

Drug: procrit/epogen cytokine? function?

A

EPO; anemia

Immunology (4 decks)

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