Random 9 Flashcards

1
Q

When do patients with T2DM start having home monitoring?

A
  • When they are started on insulin
  • When they are started on hypoglycemic medication like gliclazide.
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2
Q

When do you have to inform the DVLA about a patient with T2DM?

A

If they are on insulin
Or they are on a hypoglycemic med for more than 3 months

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3
Q

What HBA1c level is considered diabetic?

A

> 48mmol/L

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4
Q

What is DAFNE?

A

Focus: DAFNE is primarily a program for adults with type 1 diabetes. It emphasizes flexible insulin dosing to match food intake, allowing individuals to lead a more normal life, including the flexibility to eat a varied diet.

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5
Q

What is DESMOND?

A

Focus: DESMOND is designed for individuals with type 2 diabetes, both newly diagnosed and those who have been living with the condition for some time. It focuses on lifestyle changes, including diet, physical activity, and emotional well-being.

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6
Q

What egfr level should you stop Metformin at?

A

35

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7
Q

Orlistat

A

Inhibits lipase which prevents the absorption of dietary fats in the body.

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8
Q

What are some risks of obesity that are independent of T2DM?

A
  • Sleep apnoea
  • Osteoarthritis
  • Sudden death
  • NAFLD
  • GORD
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9
Q

What are DPP-4 inhibitors like sitagliptin and saxagliptin best for?

A

When you want to decrease HBA1c but not drop blood glucose too much.

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10
Q

What diabetic medication is best for weight loss?

A

GLP-1 inhibitors, semaglutide, liraglutide.

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11
Q

What diabetic medication is best for kidney protection?

A

SGLT-2 inhibitors.

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12
Q

What factors could precipitate DKA?

A
  • Failure to take insulin
  • Illness
  • Trauma, emotional
  • Hypovolaemia
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13
Q

How do patients with DKA present?

A
  • Polyuria, polydipsia
  • Dehydration
  • Abdominal pain
  • Fruity breath
  • Combative, drunk, coma
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14
Q

What is the biochemical criteria for DKA?

A

Glucose >11mmol/L
Ketones >3mmol/L
Anion gap acidosis. pH <7.3, <15mmol/L, anion gap >12

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15
Q

What are treatment targets for DKA?

A

Reducing ketones by 0.5/h
Increasing HCO3 by 3/hr
Reducing glucose by 3/hr
Maintaining K at 4.5-5.5mmol/L

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16
Q

Biochemically, what does DKA resolution look like?

A

Ketones <0.3
Bicarbonate >15
pH >7.3

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17
Q

How does mannitol help with cerebral oedema?

A

Increased osmotic force in the bloodstream
Water is drawn into the bloodstream
This movement of water reduces the swelling in the brain tissue, alleviating cerebral edema.

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18
Q

What are complications of DKA?

A
  • Shock
  • Vascular thrombosis
  • Pulmonary edema
  • Cerebral edema
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19
Q

With hypoglycemia, what do you do if the patient is conscious, orientated and able to swallow.

A

Give any of the following

  • Glass of lucozade
  • Orange juice
  • 3 dextrosol tablets
  • Tube of glucose gel
  • fortijuice for enteral feeding
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20
Q

With hypoglycemia, what do you do if the patient is conscious but confused, uncooperative or disorientated and unable to tolerate oral treatment

A

1mg of glucagon and given IM

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21
Q

With hypoglycemia, what do you do if the patient is unconscious/unable to swallow?

A

Stop any IV insulin
10% glucose infusion 200mls given over 10mins
20% glucose infusion 100mls stat.

22
Q

What is the biochemical criteria for HHS

A
  • Hypovolaemia
  • Marked hyperglycaemia (30mmol/L)
  • No Ketonaemia or acidosis
  • High osmolality >320mmol/kg
  • Older patients with intercurrent illness at a high risk
  • Low urine output
23
Q

Treatment for HHS

A
  • Fluid resuscitation
  • Full clinical examination
  • Investigations: VBG, UE, FBC, ECG, CXR
  • Cardiac monitoring
  • LMWH
24
Q

In DKA, when do you do an ABG?

A

Evereytime you change fluids

25
Q

What symptoms/signs occur at <4mmol/L of glucose

A
  • Sweating
  • Nausea
  • Fatigue
  • Tingling
26
Q

What symptoms/signs occur at <2mmol/L

A

Drowsy, seizures or a coma

27
Q

What blood sugar levels should diabetics be before they have a PET scan?

A

Your blood sugar will be measured just before the injection of the FDG (glucose). Your blood sugar must be less than 200 mg/dl for the scan to be performed. After the injection of a small amount of FDG you will be asked to rest comfortably for 50-60 minutes, to allow the cells to take up the FDG.

28
Q

What is a common side effect of PPIs?

A

Hyponatremia

29
Q

Nystatin

A

Anti-fungal that binds to ergosterol used for oral candidiasis

30
Q

What is the CK like in polymyalgia rheumatica?

A

Normal

31
Q

What is the main difference between fibromyalgia and chronic fatigue syndrome?

A

Fibromyalgia causes pain and chronic fatigue syndrome is more associated with pain.

32
Q

When you take a history for giant cell arteritis, what else should you make sure you ask questions about?

A

Polymyalgia rheumatica as they are closely linked .

Girdle stiffness.

33
Q

Is alcohol related to heart disease?

A

No

34
Q

What underpins all acute coronary syndromes?

A

Ruptured plaque

35
Q

What are the 4 steps to treating a STEMI?

A
  1. O2 and analgesia (vasodilator)
  2. 300mg of Aspirin
  3. 2nd APA like Ticagrelor
  4. PCI
36
Q

What APA should you patient have after an acute coronary syndrome if they are older than 75 and diabetic?

A

Clopidogrel instead of Ticagrelor

37
Q

Apart from reducing cholesterol, what is another advantage of a statin?

A

Stabilises the plaque

38
Q

What is the dosing for Enoxaparin?

A

1mg per kg bd

39
Q

What is the treatment for NSTEMI and UA?

A
  1. O2 and analgesia
  2. 300mg Aspirin
  3. 2nd APA
  4. LMWH (48h only)
40
Q

Who doesn’t make it to the cath lab?

A
  1. They don’t want it
  2. Dementia
  3. Actively bleeding
  4. Renal impairment
  5. Fe deficiency anaemia
  6. Frailty score >5
41
Q

What medication is given to all patients before angioplasty?

A

IV heparin

42
Q

What is a JVP going up and down indicative of?

A

Tricuspid regurgitation

43
Q

What are the symptoms of influenza infection?

A
  • Headache
  • Malaise
  • Myalgia
  • Fever >37.8
  • Non productive cough
  • Sore throat
44
Q

What is the difference in the presentation of a COVID-19 infection compared to Influenza?

A

COVID-19 presents after 5 days of infection Influenza is 1-4 days. COVID-19 is more associated with anosmia.

45
Q

How do you investigate Influenza?

A

Indirect/direct fluorescence antibody test, but rapid PCR is now often available first line.

46
Q

What is the first line antiviral for Influenza?

A

Oseltamivir

47
Q

What is the second line antiviral for Influenza?

A

Zanamivir

48
Q

What are some co-morbidities that mean patients who present with influenza should be treated with antivirals as a first line?

A
  • Heart failure (other heart diseases)
  • Metabolic disorders
  • Neurological disorders
  • Liver disorders
  • Chronic resp diseases
49
Q

What are some complications of influenza?

A

Pulmonary – viral pneumonia, secondary bacterial pneumonia (particularly S. aureus) , worsening of chronic conditions (eg. COPD and asthma)
Cardiovascular – myocarditis, heart failure
Neurological – encephalopathy
Gastrointestinal – anorexia and vomiting are common

50
Q

What are some examples of live vaccines?

A
  • MMR
  • Yellow fever
  • Chicken pox
  • Polio
  • Rotavirus