Antibiotics Flashcards
Treatement for bartonella/cat scratch disease
Oral docycline
Oral erythromycin
Oral rifampicin
Tetracycline MOA
Doxycyline, oxytetracycline
Inhibtion of protein synthesis (binds 30S ribosomal subunit)
INterferes with aminoacyle-tRNA binding
Macrolides MOA
Erythromycin
Inhibition of protein synthesis (binds 50S ribosomal subunit) Inhibits translocation of peptidyl tRNA
Lincosamide
Clindamycin, Lincomycin
Inihibition of protein synthesis (binds 50S ribosomal subunit) Inhibits peptide elongation
Streogramins MOA
Virginiamycin
Inhibition of protein sythesis
Aminoglycoside MOA
Gentamycin, neomycin, streptomycin
Inhibition of protein synthesis (binds 30S ribosomal subunit, inhibitis translocaiton of peptidyle tRNA, misreading of mRNA)
Chloramphenicol
Inhibition of protein synthesis (binds 50S ribosomal subunit, inhibits peptidyl transferase)
Beta lactams MOA
Penicillin, Ampicillin
Cephalosporins
Inhibtion of cell wall (peptidoglycan) synthesis, binds and inactivates PFPs
Sulfonamides MOA
Sulfamethoxazole,
Inhibtion of folic acid synthesis
(competitively inhibits DHPS by structural analogy with p-aminobenzoic acid)
Fluoroquinolones
Ciprofloxacin, difloxacin, moxi, sarafloxacin
Inhibit DNA replication and transcription
Inhibits DNA gyrase and topoisomerase IV)
Polypeptides MOA
Actinomycin, polymyxin
Disruption of cell membrane structure and permeability
Ionophores MOA
Nystatin Monensin
Disruption of transmembrane ion concentration
Which antibiotics inhibit protein synthesis by binding to 50S unit and 30S unit?
Macrolides, clindamycin, chloramphenicol 50S
Tetracyclines, aminoglycosides 30S
Initial treatment for corneal ulcer
Need good gram positive and gram negative cover
Combination therapy with cephalosporing or vancomycin for gram postiive cover and an aminoglycoside for gram negative.
Fluoroquinolones have good coverage against both gram postiive and gram negative
Treatment for syphilitic chorioretinitis
HIgh dose IV penicillin
Pencillin G
High dose oral amoxicillin for 1 month
