Bone Therapeutics

Question 1

how do bone therapies localize?

Answer 1

ion exchange same as dx
-intent to deliver small amount of radiation to metabolically active area repping mets

Question 2

Sr-89 is in same periodic group as what element? what does this say about Sr?

Answer 2

Ca so it has same physiological uptake mechanism and chemical properties.

Question 3

half life of Sr-89

Answer 3

50.5 d

Question 4

energy and mode of decay SR 89

Answer 4

1.46 Mev and beta emissionS

Question 5

sR-89 UPTAKE speed and turnover time?

Answer 5

rapid and retained in bone 14 d

Question 6

excretion of Sr-89

Answer 6

2/3 urinary and 1/3 fecal

Question 7

Sr-89 dose

Answer 7

4 mCi

Question 8

how is Sr-89 given

Answer 8

IV and be careeful of administration bc strontium salts will damage skin really bad

Question 9

precautions with pt treated w Sr-89

Answer 9

no caution to others bc pure beta

Question 10

Sr-89 chloride for injection brand name?

Answer 10

Metastron

Question 11

Sm-153 drug name and chemical name (EDTMP)

Answer 11

Samrium Lexidronam and ethylenediaminetetramethylenephosphonate acid

Question 12

Sm-153 EDTMP is a ________that has similar properties to _____

Answer 12

chelate, Tc99m phosphonate bone imaging agents

Question 13

Sm-153 half life

Answer 13

46.3 hrs

Question 14

energy and decay of Sm-153

Answer 14

beta and gamma (103 keV)

Question 15

sm 153percentage of uptake in skeleton varies depending on what

Answer 15

extent of mets

Question 16

sm153 avg uptake percent is

Answer 16

65% of injected dose

Question 17

Sm-153 excretion is

Answer 17

urinary

Question 18

sm153 what percent of dose is excreted after 6 hours

Answer 18

34.5 %

Question 19

how to minimize bladder irritation in Sm153 pts

Answer 19

hydrate prior and urinate often during first 24 hour

Question 20

sm 153 dose

Answer 20

1 mCi/kg of body weight

Question 21

sm153 admin

Answer 21

iv with a slow infusion

Question 22

how is Sm153 supplied

Answer 22

2-3 mL vials that are frozen with 100-150 mCi activity

Question 23

expiration of sm153

Answer 23

once thawed-8 hrs
48 hours post cal time

Question 24

commercial product name of Sm153 EDTMP

Answer 24

quadramet