Immunology and Infection

Question 1

What is the function of IL-2?

Answer 1

Maturation of cytotoxic T cells (released by CD4 cells)

Question 2

What is the function of IL-4?

Answer 2

Causes B-cell maturation into plasma cells (released by CD4 cells)

Question 3

Where do T cells come from and what kind of mediated immunity are they involved in?

Answer 3

Thymus. Involved in cell mediated immunity. Require MHC classes for activation.

Question 4

What are the primary lymphoid organs?

Answer 4

liver, bone thymus

Question 5

What is the function of of IgD?

Answer 5

This is a membrane bound receptor on B cells that serves as antigen receptor

Question 6

What is the largest antibody?

Answer 6

IgM

Question 7

Describe type I-IV hypersensitivity reactions.

Answer 7

I: immediate, IgE mediated
- ex. bee sting, peanut, hay fever
II: IgG or IgM mediated, these ab react with cell-bound antigen
-ex. ABO incompat, hyperacute reaction, MG
III: Immune complex
- Serum sickness, SLE
IV: Delayed hypersensitivity
- TB skin test, contact dermatitis
-only reaction not to involve Ab, tests cell-mediated immunity

Question 8

WHen do you give tetanus toxoid vs. tetanus immune globulin?

Answer 8

Toxoid: Give in non-tetanus prone wounds if <3 doses given or >10 years; Give always in tetanus prone wounds if unless pt got >3 doses or its been <5 years since last

Immune globulin:
- Give only in tetanus prone wounds in patients that have not been immunized