Case records

Question 1

What are the differences between aflibercept and faricimab?

Answer 1

Eylea is a VEGF trap, Vabymso is an VEGF A antibody and Ang 2 action

Question 2

What is VEFG-A thought to regulate?

Answer 2

Endothelial proliferation
Vascular permeability
Neovascularisaton

Question 3

What does the anti ANG-2effect?

Answer 3

• 1. improves vascular stability
• 2. desensitizes vessels to actions of VEGF-A

Question 4

What is eylea?

Answer 4

115kDA fusion protein. Binds to VEGF A, VEGF B and PIGF

Question 5

What types of endophthalmitis would you expect after an IVI?

Answer 5

1. Sterile
2. Infective

Question 6

What modes of action are thought to trigger endopthalmitis?

Answer 6

1. Silicon inside syring
2. Immunological reaction to drug itself
3. Infection caused by injection