Hepatology: Autoimmune Hepatitis Primary Biliary Cholangitis (PBC) Primary Sclerosing Cholangitis (PSC) Flashcards
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Primary sclerosing cholangitis is most associated with:
Primary biliary cirrhosis
Crohn’s disease
Hepatitis C infection
Ulcerative colitis
Coeliac disease
Primary sclerosing cholangitis is most associated with:
Primary biliary cirrhosis
Crohn’s disease
Hepatitis C infection
Ulcerative colitis
Coeliac disease
Primary sclerosing cholangitis causes a risk of which two cancers? [2]
cholangiocarcinoma (in 10%)
increased risk of colorectal cancer
Which type of cancer develops in around 10% of primary sclerosing cholangitis patients? [1]
Which disease is PSC commonly found alongside? [1]
Cholangiocarcinoma develops in around 10% of primary sclerosing cholangitis patients
PSC found in UC
Which medication is associated with drug-induced cholestasis? [1]
The oral contraceptive pill is associated with drug-induced cholestasis
What is Mirizzis syndrome? [1]
What is the typical triad of symptoms? [3]
Mirizzi’s syndrome:
- Mirizzi syndrome is defined as common hepatic duct obstruction caused by extrinsic compression from an impacted stone in the cystic duct or infundibulum of the gallbladde
It classically presents with jaundice, fever and RUQ pain (also known as Charcot’s triad).
Mirizzi’s syndrome occurs because of extrinsic compression from which locations? [2]
Mirizzi’s syndrome is common hepatic duct obstruction caused by extrinsic compression from a large impacted stone in the cystic duct or neck of the gallbladder (Hartmann’s pouch)
What are the serum markers of type 1 auto-immune hepatitis? [3]
Type 1 autoimmune hepatitis:
Antinuclear antibodies
anti-smooth muscle antibodies
raised IgG levels
Additionally, it is more common in young females.
What is the serum marker of type 2 auto-immune hepatitis? [1]
Anti-liver/kidney microsomal type 1 antibodies (LKM1)
What is the serum marker of type 3 auto-immune hepatitis? [1]
Soluble liver-kidney antigen
Describe the presentation of auto-immune hepatitis [5]
may present with signs of chronic liver disease
acute hepatitis: fever, jaundice etc (only 25% present in this way)
amenorrhoea (common)
piecemeal necrosis
*
Primary sclerosing cholangitis is most associated with:
Primary biliary cirrhosis
Crohn’s disease
Hepatitis C infection
Ulcerative colitis
Coeliac disease
Primary sclerosing cholangitis is most associated with:
Primary biliary cirrhosis
Crohn’s disease
Hepatitis C infection
Ulcerative colitis
Coeliac disease
Primary sclerosing cholangitis causes a risk of which two cancers? [2]
cholangiocarcinoma (in 10%)
increased risk of colorectal cancer
Which type of cancer develops in around 10% of primary sclerosing cholangitis patients? [1]
Which disease is PSC commonly found alongside? [1]
Cholangiocarcinoma develops in around 10% of primary sclerosing cholangitis patients
PSC found in UC
Which medication is associated with drug-induced cholestasis? [1]
The oral contraceptive pill is associated with drug-induced cholestasis
Mirizzi’s syndrome occurs because of extrinsic compression from which locations? [2]
Mirizzi’s syndrome is common hepatic duct obstruction caused by extrinsic compression from a large impacted stone in the cystic duct or neck of the gallbladder (Hartmann’s pouch)
