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Year 1 > Principles drugs > Flashcards

Principles drugs Flashcards

1
Q

what is the effect of H1- histamine
what G protein

A
  1. smooth muscle contraction (increases iP3)
  2. Gq
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2
Q

what does B2- adrenoreceptor do and what G proteins

A

smooth muscle relaxation (increase cAMP). Gs and Gi

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3
Q

what does M2-muscaranic receptor do. and what G protein

A

decrease heart force of contraction (decrease cAMP) as more Gi than Gs so more AC inhibited than deactivated.
Gs and Gi

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4
Q

what does muscarinic M2 receptor do when soley Gi coupled. what g protein

A

cardiac slowing. gi protein

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5
Q

what does Gq generally do

A

activate phospholipase C, which activates second messenger iP3, releasing Ca2+ from intracellular cells and activating protein kinase C

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6
Q

how does Gs work

A

activate adenyl cyclase which converts ATP-> cAMP which activates protein kinase A

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7
Q

how does Gi work

A

inhibits adenyl cyclase so inhibits production of ATP to cAMP, therefore no/less protein kinase is produced

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8
Q

how does Gi wok in K+ channels in cell membrane

A

it increases opening of channels resulting in hyperpolarisation

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9
Q

what does loratidine do
what G protein

A

gq.antagonist of H1 histamine

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10
Q

what does adrenaline do
what g receptor

A

agaonist of B2 adrenoreceptor. gi and gs

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11
Q

what does salbutamol do
what g receptor

A

agonist of B2 adrenoreceptor. gi and gs

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12
Q

what does propanolol do
what g protein

A

antagonist of B2 adrenoreceptor
Gs and Gi

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13
Q

what does acetylcholine do and what g receptor

A

M2 agonist. gs and gi

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14
Q

what does atropine do

A

Muscaranic antagonist. gs and gi

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15
Q

what does acetylcholine do in cell membrane

A

m2 agonist . gi.so increases opening of K+ channels

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16
Q

wat does atropine do

A

antagonist of M2

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17
Q

what are the ligand gated ion channels

A

Nicotinic ACh receptor

GABAA receptor
glycine receptor
5HT3 receptor
glutamate receptors (NMDA)

18
Q

what are the G protein coupled receptors

A

Muscarinic ACh receptors
Adreno-receptors
acetylcholine receptors
adrenoceptors
neuropeptide
hemokine receptors
protease activated receptors

19
Q

what are the enzyme linked receptors types

A

Insulin receptor
serine/ threonine kinase
Cytokine receptor

20
Q

what are examples of receptors that affect gene transcription

A

Steroid and thyroid hormone receptors

21
Q

give examples of receptors linked to ion channels

A

ligand gated ion channels or iotrophic receptors

22
Q

what are the receptors linked to ion channels

A

ligand gated ions or ioonotrophic receptors

23
Q

what are the G couple protein receptos

A

metabotrophic receptors

24
Q

what are the enzyme linked receptors

A

kinase

25
Q

give an example of Gq receptor

A

prostanoid

26
Q

give to examples of Gi protein couples receptos

A

opoid and cannabinoid

27
Q

what G protein is cannabinoid receptor

A

Gi

28
Q

what G protein is serotonin receptor

A

Gs

29
Q

give two examples of Gs receptors

A

histamine and serotonin

30
Q

what are the enzyme receptors

A

tyrosine kinase, serine/threonine and insuline receptor

31
Q

what ae the GPCR receptors

A

thyroid stimulating hormone receptor

32
Q

what are the intracellular receptors

A

nuclear/cytoplasmic, oestrogen receptor, vitamin D receptor. including steroid drugs and hormones, thyroid hormones, vitamins A and D, various lipids and xenobiotics

33
Q

what receptors are .lipid soluble and which ones are water soluble

A

GPCR/enzyme receptor= water soluble
allintracellular inc steroids = lipid soluble

34
Q

how does Gs work

A

– stimulates adenylyl cyclase, causing increased cAMP

35
Q

how does Gi work

A

inhibits adenylyl cyclase, causing decreased cAMP

36
Q

how does Gq work

A

activates phospholipase C, increasing production of second messengers inositol triphosphate and diacylglycerol

37
Q

give an example of where G protein couples found and describe how it works

A

e.g. there are G protein-gated potassium channels in cardiac muscle which contributes to the regulation of heart rate (Ach released from vagus nerve binds to the G-protein coupled receptor which leads to opening of K channels

38
Q

what are the 2 other names for G protein couples

A

metaboric or 7TDM

39
Q

what does G protein coupled receptors structures combine

A

Structures comprise seven membrane-spanning 𝛼 helices, often linked as dimeric structures

40
Q

what are 2 important receptors in enxyme linked receptors

A

MAP kinase pathway – important for cell division, growth and differentiation
JAK/STAT pathway – important for synthesis and release of inflammatory mediators

41
Q
A
42
Q
A

Year 1 (19 decks)

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