PRADAXA

Question 1

The trade nam “Pradaxa” refers to …

Answer 1

dabigatran (anticoagulant)

Question 2

What is the indication for use of Pradaxa?

Answer 2

• prevention of stroke and systemic embolis in adult patients with non-valvular atrial fibrillation with one or more of the following risk factors:

1. previous stroke
2. TIA or systemic embolism
3. left ventricular ejection fraction <40%
4. symptomatic heart failure
5. Age>/= 75 years
6. age >/= 65 with diabetes mellitus, CAD, hypertension

Question 3

What is the MOA of dabigatran?

Answer 3

direct thrombin inhibitor

Question 4

What is the recommended daily dose of dabigatran?

Answer 4

300mg to be taken as one 150mg capsule 2x daily

Question 5

Clearance of dabigatran in patients with renal insufficienty will take _________.

Answer 5

longer

Question 6

When should dabigatran be stopped for a patient with >/= 80CrCL with high risk of bleeding before major/elective surgery?

CrCL- indicative of renal function

Answer 6

2 days before

80CrCL- good renal function

Question 7

When should dabigatran be stopped for a patient with >/=50-<80CrCL with high risk of bleeding before major/elective surgery?

Answer 7

2-3 days before

Question 8

When should dabigatran be stopped for a patient with >/=30- <50 CrCL with high risk of bleeding before major/elective surgery?

Answer 8

4 days before

Question 9

When should dabigatran be stopped for a patient with >/=30- <50 CrCL with standard risk of bleeding before major/elective surgery?

Answer 9

2-3 days before (>48 = hours)

Question 10

When should dabigatran be stopped for a patient with >/=50-<80CrCL with standard risk of bleeding before major/elective surgery?

Answer 10

1-2 days before

Question 11

When should dabigatran be stopped for a patient with >/= 80CrCL with standard risk of bleeding before major/elective surgery?

Answer 11

24 hours before