Neuromuscular Drug Doses

Question 0

Succinylcholine

Onset,Peak, DOA

Answer 0

O: IV 30-60 sec. (40sec); IM 2-3min
P: 60 sec.
DOA: IV 4-6min (5); IM 10-20 min. (15min)

Question 1

Succinylcholine

• how supplied
• dose

Answer 1

• Supplied 20mg/ml (500mg powder for infusion)
• IV 0.7-1mg/kg (1.5 if pre-treated)
• Infusion dose 0.5-10mg/kg titrated (<5mg/kg avoids phase 2 block)

Question 2

D-Tubocurarine (Curare) dose for pre-treatment of Sux

Answer 2

3-5mg (4mg)

Question 3

Pancuronium (Pavalon) Dosing

Answer 3

Intubating Dose: 0.05-0.1 mg/ kg
Bolus after Sux: 0.05mg/kg
Maint.: 0.01-0.05mg/ kg

Question 4

Pancuronium (Pavalon)

Onset, Peak, duration

Answer 4

O: 2-3 minutes (2 1/2 min)
P: 3-5min (4min)
D: 60-90min (75min)

Question 5

Atracurium (Tracurium) Doses

Answer 5

Intubation: 0.3-0.5mg/kg (0.4mg/kg)
Maint.: 0.1-0.2mg/kg
Infusion: 5-9mcg/kg/min (7mcg/kg/min)

Question 6

Atracurium (Tracurium)

Onset, peak, DOA

Answer 6

O: 2-3 minutes (2 1/2 min.)
P: 3-5min (4min)
D: 20-35min

Question 7

Cisatracurium (Nimbex) doses

Answer 7

Intubation: 0.15-0.2 mg/kg (10% for priming dose)
Bolus after Sux: 0.1mg/kg
Maint.: 0.03mg/ kg
Infusion: 1-5mcg/kg/min (3mcg/kg/min)

Question 8

Cisatracurium (Nimbex)

Onset, Peak, DOA

Answer 8

O: 2-3 min. (2 1/2min)
P: 3-5min (4min)
D: 30-60min (45min)

Question 9

Vecuronium (Norcuron) doses

Answer 9

Intubation: 0.08-0.1mg/kg ( 0.15-0.2 RSI)
Bolus after Sux: 0.04-0.06mg/kg (0.05mg/kg)
Maint: 0.01-0.05mg/kg (0.03mg/kg)
Infusion: 1-2mcg/kg/min
Priming dose: 10% of intubation dose 3-5 minutes prior

Question 10

Vecuronium (Norcuron)
Onset, Peak, DOA
*(not recommended for RSI)

Answer 10

O: <3min
P: 3-5min (4min)
D: 20-40min (30min)

Question 11

Rocuronium (Zemuron) doses

Answer 11

Intubation: 0.6-1.2mg/kg (0.9mg/kg)
After Sux bolus: 0.6mg/kg
Maint: 0.06-0.6mg/kg (10-50% of intubating dose)
Infusion: 5-15mg/kg (10mg/kg)
Can give priming dose of 10% 3-5 minutes prior to intubation

Question 12

Rocuronium (Zemuron)
Onset, Peak, DOA
*recommended for RSI

Answer 12

O: 60-90sec (75sec)
DOA: 20-40min (30 min)
Peak: not noted in notes

Question 13

Mivacurium (Mivacron) doses

Answer 13

Intubation: 0.15-0.25mg/kg
Bolus after Sux: 0.15mg/kg
Main: 0.01-0.1mg/kg
Infudion: 1-15mcg/kg/min (7.5mcg/kg/min)

Question 14

Mivacurium (Mivacron)

Onset, Peak, DOA

Answer 14

O: 1.5-3min
P: 1-3min
D: 12-20min