Antimicrobial therapies Flashcards
What are some of the major antibiotic resistant bacterias?
Methicillin-resistant Staphylococcus aureus (MRSA)
Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria
Vancomycin-resistant Enterococcus (VRE)
What is bacterial sepsis?
Bacterial sepsis is a life-threatening condition that arises due to the body’s overwhelming response to an infection that can lead to tissue damage, organ failure and death
Bacteria > Tissue damage > Disease > Enters the bloodstream > Multiple organ dysfunction > Death
What are some of the global impacts of antibiotic resistant bacteria
1) Increased mortality due to resistant infections being more challenging to treat
2) Economic costs = increased healthcare cost, reduced GDP
3) limited treatment options
What are some recent antibiotic treatment advancements?
Aycaz = ceftazidime + avibactam
Fetroja = Cefiderocol
What are some of the potential outcomes of the failure to develop new antibiotics?
Death rate for bacterial sepsis will exceed cancer
A reduction in the global GDP
Life expectancy reduced by 20%
Add picture of other advances
Cefiderocol
Antibacterial that targets 30S ribosomes
(Large molecule)
Ceftazidime + Avibactam
Antibacterial, targets cell walls
(Medium molecules)
What antibiotics are MRSA strains resistant to?
Methicillin, beta- lactams
Name another bacteria resistant to many antibiotics
Pseudomonas aeruginosa
List the antibiotic (types) resistant to bacteria
Amino-glycosides (Gentamicin), Beta-lactams (Penillins), Tetracyclines (Doxyclyine)
What are the new strategies to treating bugs?
