Invasion and metastasis Flashcards
carcinoma in situ
Cancer cells just in epithelial cells and not passed through the basement membrane
Invasive carcinoma
Cancer cells does invade past the basement membrane
micro-invasive carcinoma
Cancer cells only just through the basement membrane 1-2mm
How does a carcinoma invade the basement membrane?
uses proteases and enzymes to degrade the collagen and other materials of the basement membrane
Once through the basement membrane, tumour cells invade the e______ matrix
extracellular
Tumour cells can then invade the venous blood supply of l_____ system
lymphatic
Tumours need their own b____ s____ to grow into larger lumps
blood supply
Tumour cells needs to be m____ to metastasis
mobile
What helps a tumour cell motility?
Tumour cell derived motility factors, breakdown products of extracellular matrix
How do tumour cells evade the host’s immune defence?
Aggregates with platelets, can shed the surface antigens and can stick to other tumour cells
What do the tumour cells needs to grow at the metastatic site?
Growth factors (often self-derived)
What are angiogenesis promoters?
Vascular endothelial growth factor, basic fibroblast growth factor
What are angiogenesis inhibitors?
Angiostatin, endostatin, vasculostatin
What is avastin an inhibitor of?
Angiogenesis
Where is a common place for metastasis?
Lungs (like a filter)
