BIOCHEMISTRY Flashcards

1
Q

What biomolecules are considered the most abundant and functionally diverse in the living system?
A. Proteins
B. Carbohydrates
C. Nucleic acid
D. Fatty acid
E. Terpenoids

A

Proteins

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2
Q

Which of the following statements is correct about protein structure?
I. The primary structure of a protein involves alpha-helics, beta-sheets and other types of folding patterns that occur due to a regular repeating pattern of hydrogen bond formation.
II. The secondary structure consist of the amino acids sequence along the chain.
III. The tertiary structure involves electrostatic and hydrophobic interactions, van der waals interaction, and hydrogen and disulfide bonds,
IV. Quaternary structure refers to the interaction of one or more subunits to form a functional protein, using the same force that stabilize the tertiary structure.
A. I only
B. I and II
C. II and III
D. I and IV
E. III and IV

A

III and IV

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3
Q

Accumulated misfolded proteins occur in variety of disease. Which of the following proteins is misfolded in patients with Alzheimer’s disease?
A. Prion protein
B. Alpha-synuclein
C.Glutamine stretches
D. Beta-amyloid
E. None of these

A

Glutamine stretches

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4
Q

Hemoglobinopathies result from mutations that produce alterations in the structure of hemoglobin. One common mutation result is sickle cell anemia, in which a mutated form of hemoglobin distorts the RBC into a crescent shape at low oxygen levels. Sickle cell anemia happens when:
A. Valine is being substituted by glutamine at codon number 6
B. Glutamic acid is being substituted by valine at position number 6
C. Glutamine is intercalated by histidine at codon number 6
D. Gene transcription is disrupted
E. None of these

A

Glutamic acid is being substituted by valine at position number 6

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5
Q

Acid-base disturbances occur under a variety of conditions. Which of the following is the result of hyperventilation due to retention of carbon dioxide in the lungs.
A. Respiratory acidosis
B. Respiratory alkalosis
C. Metabolic acidosis
D. Metabolic alkalosis
E. Lactic acidosis

A

Respiratory acidosis

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6
Q
  1. In amino acids, the pH at which the number of positive charges equals the number of negative charges is termed as_______?
    A. Chirality
    B. Amphoteric property
    C. Optical activity
    D. Isoelectric point
    E. Zwitterions
A

Isoelectric point

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7
Q

Molecules that contain an equal number of ionizable groups of opposite charge and that therefore bear no net charge are termed as____________
A. Chirality
B. Amphoteric property
C. Optical activity
D. Isoelectric point
E. Zwitterions

A

Zwitterions

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8
Q

Problems associated with connective tissues and structural protein are present in a number of disease. In scurvy, hydroxylation of proline residues is decrease and an unstable form of collagen is produced. Bones, teeth, blood vessels and other structures rich in collagen develop abnormally. Bleeding gums and poor wound healing are often observed. Which of the following vitamin deficiencies is associated to scurvy?
A. Vitamin C
B. Vitamin E
C. Vitamin A
D. Vitamin D
E. Vitamin K

A

Vitamin C

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9
Q

Which of the following is true about insulin functions
I. Insulin is release form the pancreas when blood glucose levels are elevated
II. Insulin promotes the transport of glucose into muscle and fat cells
III. Insulin promotes the storage of energy
IV. Insulin increases glycogen catabolism in the liver and muscles
A. I and II
B. I, II and III
C. I, II and IV
D. I only
E. I, II, III, and IV

A

I, II and III

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10
Q

The enzyme kinetics can be described by what equation?
A. Noyes-Whitney Equations
B. Henderson- Hasselbach Equation
C. Arrhenius Equation
D. Van Slyke Equation
E. Michaelis-Menten Equation

A

Michaelis-Menten Equation

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11
Q

Evaluate the given statements.
(1) Competitive inhibitors compete with the substrate for binding at the allosteric site of the enzyme.
(2) Noncompetitive inhibitors bind to the enzyme or the enzyme substrate complex at the active site.
A. Only I is correct
B. Only II is correct
C. I and II are correct
D. I and II are incorrect

A

I and II are incorrect

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12
Q

In phenylketonuria, the enzyme phenylalanine hydroxylase is deficient. Which of the following statements is not true about the condition?
A. Phenylketonuria happens as a result of accumulated phenylalanine in the body
B. Tyrosine becomes a essential amino acid among phenylketonuric patients
C. Aspartame is recommended for phenylkotenuric patients
D. Phenylalanine non metabolism leads to mental retardation.
E. None of these

A

Aspartame is recommended for phenylkotenuric patients

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13
Q

Which of the following is not a basic amino acid?
A. Histidine
B. Leucine
C. Lysine
D. Arginine
E. None of these

A

Leucine

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14
Q

What are the amide linkages between the alpha-carbonyl group of one amino acid and alpha amino group of another?
A. Peptide bonds
B. Disulfide bonds
C. Hydrogen bonds
D. Hydrophobic bonds
E. Ionic bonds

A

Peptide bonds

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15
Q

Edman’s reagent is used to label the amino terminal residue under mildly alkaline conditions. What is the component of this reagent?
A. Monosodium glutamate
B. Alpha-naphthol
C. Picric acid
D. Phenylisothiocyanate
E. None of these

A

Phenylisothiocyanate

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16
Q

Several different polypeptide helices are found in nature, but the alpha-helix is the most common. What bond stabilizes this helix?
A. Hydrogen bond
B. Peptide bond
C. Phosphodiester bond
D. Hydrophobic bond
E. Ionic bond

A

Hydrogen bond

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17
Q

What protein structures reverse the direction of a polypeptide chain, helping it form a compact, globular shape?
A. alpha-helices
B. beta-sheets
C. Beta-bends
D. All of these
E. Ionic bond

A

alpha-helices

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18
Q

What specialized group are required for the proper folding of many species of proteins?
A. Chaperones
B. Heat shockproteins
C. Beta bends
D. A and B
E. A and C

A

Chaperones

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19
Q

Many proteins consist of a single polypeptide chain, and are defined as monomeric proteins. However, others may consist of two or more polypeptide chains that may be structurally identical or totally unrelated. These statements describe what protein structure?
A. Primary structure
B. Secondary structure
C. Tertiary structure
D. Quaternary structure
E. None of these

A

Quaternary structure

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20
Q

What protein is misfolded in Creutzfeldt-Jakob disease?
A. Prion
B. Glutamine stretches
C. Beta-globin
D. Beta-amyloid
E. None of these

A

Prion

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21
Q

What are the two most abundant hemeproteins in humans?
A. Hemoglobin and myoglobin
B. Hemoglobin and cytochrome oxidase
C. Hemoglobin and catalase
D. Cytochrome and catalase
E. All of these

A

Hemoglobin and myoglobin

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22
Q

The complex of protoporphyrin IX and ferrous iron is termed as ___?
A. Heme
B. Hemoglobin
C. Transferrin
D. Ferritin
E. Myoglobin

A

Heme

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23
Q

What is the hemeprotein found in heart and skeletal muscles which functions both as a reservoir for oxygen and as an oxygen carrier that increases the rate of transport of oxygen within the muscle cell?
A. Hemoglobin
B. Myoglobin
C. Actin
D. Myosin
E. Keratin

A

Myoglobin

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24
Q

This is found exclusively in red blood cells (RBCs) where its main function is to transport oxygen (O2) from the lungs to the capiliaries of the tissues.
A. Myoglobin
B. Keratin
C. Collagen
D. Hemoglobin
E. Myosin

A

Hemoglobin

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25
Q

The major hemoglobin in adults compromising of four polypeptide chains held together by noncovalent interaction.
A. Hemoglobin A
B. Hemoglobin T
C. Hemoglobin R
D. Hemoglobin F
E. Hemoglobin C

A

Hemoglobin A

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26
Q

These are hereditary hemolytic disease in which an imbalance occurs in the synthesis of globin chains.
A. Sickle cell anemia
B. Thalassemia
C. Microcytic anemia
D. Iron deficiency anemia
E.Hyperchromic anemia

A

Thalassemia

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27
Q

Oxidation of the heme component of hemoglobin to the ferric ion (fe3+) state forms:
A. Carboxyhemoglobin
B. Methemoglobin
C. Ferritin
D. Transferrin
E. Porphyrin

A

Methemoglobin

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28
Q

Collagen and elastin are examples of:
A. Fibrous proteins
B. Globular proteins
C. Albumins
D. Metalloproteins
E. Enzymes

A

Fibrous proteins

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29
Q

What is the most abundant protein in the human body?
A. Keratin
B. Elastin
C. Collagen
D. Hemoglobin
E. Myoglobin

A

Collagen

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30
Q

Fibril forming collagen, EXCEPT:
A. Type I
B. TYPE II
C. Type III
D. Type IV
E. None of these

A

Type IV

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31
Q

Which of the following pairs is correct about collagen types?
A. type I: Fibril associated collagen
B. Type II: Network forming collagen
C. Type III: Fibril-forming collagen
D. Type IV: Fibril forming collagen
E. Type IX: Network forming collagen

A

Type III: Fibril-forming collagen

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32
Q

Collagen is rich in ___ and ___, both of which are important in the formation of the triple-stranded helix.
A. Proline and leucine
B. Proline and isoleucine
C. Proline and glycine
D.Proline and histamine
E. Proline and tyrosine

A

Proline and glycine

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33
Q

A heterogenous group of generalized connective tissues disorders that result from inheritable defects in the metabolism of fibrillar collagen molecules, and can result from a deficiency of collagen processing enzymes (for example, lysyl hydroxylase or or procollagen peptidase), or from mutations in the amino acids sequences of collagen types I, III or V.
A. Ehlers-Danlos syndrome
B. Von Gierke’s syndrome
C. Osteogenesis imperfect
D. Huntington’s disease
E. Hurler’s syndrome

A

Ehlers-Danlos syndrome

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34
Q

A connective tissue protein with rubber like properties in tissues such as the lung.
A. Collagen
B. Keratin
C. Elastin
D. Albumin
E. Hemoglobin

A

Elastin

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35
Q

A connective tissue disorder that characterize by impaired structural integrity in the skeleton, the eye, and the cardiovascular system.
A. Hurler’s disease
B. Marfan syndrome
C. Rheumatoid arthritis
D. Gaucher’s disease
E. Huntington’s disease

A

Marfan syndrome

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36
Q

Lactate pyruvate conversion is possible due to the presence of lactic dehydrogenase. What enzyme category does lactic dehydrogenase belong?
A. Hydrolase
B. Oxidoreductase
C. Transferases
D. Lyases
E. Isomerases

A

Oxidoreductase

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37
Q

Which of the following pairs is incorrect about the intacellular location of the biochemical pathways?
A. Lysosome: Macromolecular degradation
B. Nucleus: Protein synthesis
C. Cytosol: Glycolysis
D. Mitochondria: Fatty acid oxidation
E. Cytosol: HMG shunt

A

Nucleus: Protein synthesis

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38
Q

What is the process of recycling protein into their constituent amino acid, for reuse by the cell?
A. Protein catabolism
B. Protein turnover
C. Protein synthesis
D. Protein denaturation
E. Protein degradation

A

Protein turnover

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39
Q

A large protein that may contain two or more regions of the polypeptide chain that individual individually have a compact folded structure is called ______.
A. Domains
B. Chaperones
C. Residues
D. Proteasome
E. None of these

A

Domains

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40
Q

The following are true about amino acid, EXCEPT:
A. They may polymerized to form polypeptides
B. They serve as precursors for other small biomolecules
C. They may be oxidized to serve as an energy source for the cell
D. They act as building blocks of fatty acids
E. None of these

A

They act as building blocks of fatty acids

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41
Q

Of the 20 important amino acids, which is considered optically active?
A. Proline
B. Lysine
C. Arginine
D. Leucine
E. Glycine

A

Glycine

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42
Q

The following amino acids contain sulfur on their structure, EXCEPT:
A. Cysteine
B. Methionine
C. Tyrosine
D. Leucine
E. Glycine

A

Tyrosine

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43
Q

Which of the following amino acids does not contain benzene ring on its structure?
A.Tyrosine
B. Phenylalanine
C. Tryptophan
D. All of these
E. None of these

A

None of these

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44
Q

RNAs with catalytic activity are called
A. Apoenzymes
B. Zymogens
C. Proenzymes
D. Ribozymes
E. Holoenzymes

A

Ribozymes

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45
Q

The number of molecules of substrate converted to product per enzyme molecule per second
A. Bloom strength
B. Turnover number
C. Saponification number
D. Conformational change
E. None of these

A

Turnover number

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46
Q

Which of the following is incorrectly paired?
A. Holoenzyme: active enzyme
B. Apoenzyme: inactive enzyme
C. Cofactor: inorganic molecule
D. Coenzyme: Small organic molecule
E. Prosthetic group: transiently associated with the enzyme

A

Prosthetic group: transiently associated with the enzyme

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47
Q

Which of the following is false about the kinetic order of enzyme?
A. When the substrate concentration [S] is much lesser than the Km, the rate of reaction is first order.
B. When [S] is much greater than Km, the velocity is constant and equal to Vmax.
C. When [S] is much less than Km, the velocity of the reaction is approximately proportional to the substrate concentration.
D. When the substrate concentration [S] is greater than the Km, the rate of reaction is zero order.
E. None of these

A

None of these

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48
Q

Irreversible inhibitors bind to enzymes through what bond?
A. Covalent bond
B. Ionic bond
C. Hydrogen bond
D. Hydrophobic bond
E. Sigma and pie bonds

A

Covalent bond

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49
Q

Which of the following is true about competitive inhibitions?
A. The reaction of the substrate and inhibitor is irreversible
B. Substrate binds to active site, inhibitor binds to allosteric site
C. Inhibitor is covalently bonded to the enzyme
D. The reaction is not surmountable
E.None of these

A

The reaction of the substrate and inhibitor is irreversible

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50
Q

This occurs when inhibitor and substrate bind at different site on the enzyme.
A. Competitive inhibition
B. Non-competitive inhibition
C. Functional inhibition
D. Chemical inihibition
E. Physiological inhibition

A

Non-competitive inhibition

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51
Q

Enzyme are often measured in clinical diagnosis. Which of the following is correlatable to an elevated alanine aminotransferase?
A. Brain tumor
B. Hepatic damage
C. Prostate cancer
D. Colon cancer
E. Eye injury

A

Hepatic damage

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52
Q

ADH requires NAD+ for catalytic activity. In the reaction catalyzed by ADH, an alcohol is oxidized to an aldehyde as NAD+ is reduced and dissociates from the enzyme. The NAD+ is functioning as a (an):
A. Apoenzyme
B. Coenzyme-cosubstrate
C. coenzyme-prosthetic group
D. cofactor
E. Eye injury

A

Coenzyme-cosubstrate

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53
Q

Which of the following is not true about the digestion of protein?
A. Protein digestion begins in the mouth
B. The digestion of protein may be due gastric acid secretion
C. Pancreatic enzyme aid in the digestion of protein
D. Aminopeptidases digest oligopeptides in the small intestine
E. None of these

A

Protein digestion begins in the mouth

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54
Q

What is most common genetic error of amino acid transport?
A. Phenylketonuria
B. Alkaptonuria
C. Cystinuria
D. Methemoglobinemia
E. Pellagra

A

Cystinuria

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55
Q

A disease of malabsorption resulting from immune-mediated damage to the small intestine in the response to ingestion of gluten
A. Cystic fibrosis
B. Celiac disease
C. Ulcerative disease
D. Crohn’s disease
E. Conn’s disease

A

Celiac disease

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56
Q

What is the first step of metabolic catabolism?
A. Conjugation
B. Transamination
C. Transpetidation
D. Hydrolysis
E. Reduction

A

Transamination

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57
Q

All amino acids participate in transamination at some point in their catabolism, EXCEPT:
A. Lysine
B. Threonine
C. Tryptophan
D. A and B
E. A and C

A

A and B

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58
Q

What is the only amino acid that undergoes rapid oxidative deamination?
A. Lysine
B. Tyrosine
C. Glutamate
D. Tryptophan
E. Ornithine

A

Glutamate

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59
Q

In the transport of ammonia from the peripheral tissues to the liver, which of the following, mechanism is true?
A. Glutamine is transported in the blood to the liver where it is cleaved by glutaminase to produce glutamate and free ammonia
B. Alanine is transported by the blood to the liver, where it is converted to pyruvate by transamination
C. Transamination of pyruvate to alanine is required to allow transport of alanine to the liver.
D. A and B
E. All of these

A

All of these

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60
Q

Where is the production and excretion site?
A. Liver for production, kidney for excretion
B. Muscle for production, kidney for excretion
C. Liver for production, mammary gland for excretion
D. Liver for both production and excretion
E. None of these

A

Liver for production, kidney for excretion

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61
Q

What amino acid is the immediate precursor of both ammonia and aspartate nitrogen?
A. Glutamate
B. Aspartate
C. Pyruvate
D. Oxaloacetate
E. Lactate

A

Glutamate

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62
Q

The synthesis of urea is located on which cell site?
A. Mitochondria
B. Cytosol
C. DNA
D. A and B
C. All of these

A

A and B

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63
Q

Ammonia is produced by all tissues during the metabolism of a variety of compounds. However, The level of ammonia in the blood must be kept really low, because even slightly elevated concentrations (Hypoammonemia) are toxic to what part of the body system?
A. Autonomic nervous system
B. Central nervous system
C. Integumentary system
D. Skeletal system
E. Digestive system

A

Central nervous system

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64
Q

The following are potential sources of ammonia, EXCEPT
A. Glutamine
B. Monoamines
C. Purines
D. Pyrimidines
E. Resorcinol

A

Resorcinol

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65
Q

What two nitrogen-containing compounds are incorporated in the urea cycle?
A. Alanine and glutamate
B. Glutamine and alanine
C. Aspartate and ammonia
D. Ammonia and aspartate
E. Alanine and arginine

A

Ammonia and aspartate

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66
Q

Evaluate the two statements.
(1) Essential amino acids must be obtained from diet in order for normal protei synthesis to occur
(2) Essential amino acids are produced from the intermediates of metabolism of protein.
A. Only 1 is correct
B. Only 2 is correct
C. Both are correct
D. Both are incorrect

A

Only 1 is correct

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67
Q

Amino acids whose catabolism yields either acetoacetate or one of its precursors (Acetyl CoA or acetoacetyl CoA) are termed as. . .
A. Glucogenic amino acids
B. Ketogenic amino acids
C. Metabotropic compounds
D. Amphoteric amino acids
E. Zwitterionic amino acids

A

Ketogenic amino acids

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68
Q

Which of the following amino acids doesn’t belong to the group?
A. Tyrosine
B. Isoleucine
C. Phenylalanine
D. Lysine
E. Tryptophan

A

Lysine

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69
Q

The amino acids leucine, isoleucine and valine are:
A. Branched-chain amino acids
B. Essential amino acids
C. Aromatic amino acids
D. A and B
E. C and D

A

A and B

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70
Q

Succinyl CoA, A Kreb’s cycle intermediate may be derived from the degradation of the following, EXCEPT
A. Valine
B. Isoleucine
C. Theonine
D. Aspargine
E. None of these

A

Aspargine

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71
Q

The most common clinically encountered inborn error of amino acid metabolism
A. Tyrosinemia type I
B. Phenylketonuria
C. Albinism
D. Maple syrup urine disease
E. Pellagra

A

Phenylketonuria

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72
Q

Tyrosine is needed in the synthesis of the following, EXCEPT:
A. Tissue protein
B. Melanin
C. Catecholamines
D. Fumarate
E. Phenylacetate

A

Phenylacetate

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73
Q

The following are clinical characteristics of classical phenylketonuria:
A. Elevated phenylalanine
B. CNS symptoms
C. Hypopigmentation
D. Blue eyes
E. All of these

A

All of these

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74
Q

A disease which is characteristic by feeding problems, vomiting, dehydration, severe metabolic acidosis. This condition is due to partial or complete deficiency in the branched-chain alpha-keto acid dehydrogenase.
A. Phenylketonuria
B. Maple syrup urine disease
C. Pellagra
D. Albinism
E. Hypopigmentation

A

Maple syrup urine disease

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75
Q

Albinism refers to a group of conditions in which a defect in tyrosine metabolism results in a deficiency in the production of
A. Melatonin
B. Melanin
C. Melanocyte
D. All of these
E. None of these

A

Melanin

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76
Q

The homocystinurias are a group of disorders involving defects in the metabolism of homocysteine. The most common cause of homocystinuria is a defect in the enzyme cystathionine beta-synthase. Patients can be responsive (or nonresponsive) to oral administration of vitamin coenzyme of crystathionine beta-synthase. What vitamin is referred to in this condition?
A. Thiamine
B. Niacin
C. Pantothenic acid
D. Pyridoxine
E. Biotin

A

Pyridoxine

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77
Q

Which of the following amino acid should be avoided of by patients with alkaptonuria?
A. Phenylalanine
B. Tyrosine
C. Alanine
D. A and B
E. B and C

A

A and B

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78
Q

Which of the following pairs (precursor 🡪 product) is incorrect?
A. Histidine -> histamine
B. Trytophan -> serotonin
C.Arginine -> nitric oxide
D. Methionine -> purine/pyrimidine
E. Tyrosine -> dopamine

A

Methionine -> purine/pyrimidine

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79
Q

Which one of the following statements concerning a 1 week old male infant with undetected classic phenylketonuria is correct?
A. Tyrosine is a nonessential amino acid
for the infant
B. High levels of phenylpyruvate appear in his urine
C. Therapy must begin within the first year of life
D. A diet devoid of phenylalanine should be initiated immediately
E. When the infant reaches adulthood, it is recommended that diet therapy be discontinued

A

High levels of phenylpyruvate appear in his urine

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80
Q

The structure of porphyrin is shown below. Which cyclic organic molecule is present on the structure?
A. Indole
B. Pyrrole
C. Quinolone
D. Pyridine
E. Piperidine

A

Pyrrole

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81
Q

The most prevalent metalloporphyrin in humans is heme. It serves as a prosthetic group for:
A. Cytochrome
B. Hemoglobin
C. Peroxidase
D. All of these
E. A and B

A

All of these

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82
Q

Inherited (or occasionally acquired) defect is heme synthesis may result to:
A. Porphyria
B. Phenylketonuria
C.Methemoglobinemia
D. Lead poisoning
E.Albinism

A

Porphyria

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83
Q

What is the approximate number of days of red blood cells to be in the circulation before degradation?
A. 40 days
B. 80 days
C. 120 days
D. 150 days
E. 365 days

A

120 days

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84
Q

Bilirubin and biliverdin are examples of:
A. Bile salts
B. Bile pigments
C. Bile duct
D. All of these
E. None of these

A

Bile pigments

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85
Q

Certain anionic drugs, such as salicylates and sulfonamides, can displace bilirubin from albumin, permitting bilirubin to enter the central nervous system. This cause the potential for neural damage in infants known as:
A. Saint Louis Encephalitis
B. Systemic Lupus Erythematosus
C. Steven-johnson’s syndrome
D. Kernicterus
E. All of these

A

Kernicterus

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86
Q

Van de Bergh reaction determines the concentration of:
A.Protein
B. Bilirubin
C. Heme
D. Glucose
E. Cholesterol

A

Bilirubin

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87
Q

The following are catecholamines, EXCEPT:
A. Epinephrine
B. Norepinephrine
C. Acetylcholine
D. Dopamine
E. None of these

A

Acetylcholine

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88
Q

What organic polymer protects underlying cell from the harmful effects of sunlight?
A. Melanin
B. Keratin
C. Collagen
D. Catecholamines
E. Heme

A

Melanin

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89
Q

The 4D symptoms of pellagra include: diarrhea, dermatitis, dementia and death. This is due to the deficiency of:
A. Niacin
B. Tyrosine
C. Tryptophan
D. A and C
E. A and B

A

A and C

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90
Q

Tryptophan
i.One-letter representation is “T”
ii. Non polar molecule
iii. Deficiency of which can cause Hartup disease
iv. The structure contains phenol side chain
A. I & II are correct
B. I, II, and III are correct
C. II and III are correct
D. I, II, III and IV are correct
E.I, II, III and IV incorrect

A

II and III are correct

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91
Q

What is the isoelectric point (pl) of arginine?
A. 7.87
B. 5.55
C. 10.75
D. 7.3
E. 11.8

A

10.75

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92
Q

Estimate the isoelectric point of the structure (reaction mechanism) given below.
A. 2
B. 9
C. 6
D. 5
E. 7

A

6

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93
Q

Which of the following secondary derived proteins have highest molecular weight characteristic?
A. Proteoses
B. Peptones
C. Peptides
D.A and B
E. B and C

A

Proteoses

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94
Q

Tyrosine can be detected by:
A Xanthoproteic test
B. Millon’s test
C. Sakaguchi test
D. A, B and C
E. A and B

A

A and B

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95
Q

Hopkin’s cole reaction gives positive result in:
A. Gelatin
B. Collagen
C. Tryptophan
D. A and B
E. B and C

A

Tryptophan

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96
Q

Which of the following is an essential amino acid in man?
A. Tyrosine
B. Proline
C. Aspartate
D. Threonine
E. Serine

A

Threonine

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97
Q

Which of the following amino acids is NOT basic?
A. Lysine
B. Arginine
C. Ornithine
D. Glutamine
E. Histidine

A

Glutamine

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98
Q

Which of the following bonds is not affected by denaturation due to its high stability?
A. Disulfide bond
B. Peptide bond
C. Hydrogen bond
D. Ionic bond
E. None of these

A

Peptide bond

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99
Q

Arginine and histidine are:
A. Essential amino acid
B. Non essential amino acid
C. Semi-essential amino acid
D. Acidic amino acid
E. Aromatic amino acid

A

Semi-essential amino acid

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100
Q

A tripeptide involved in cellular oxidation-reduction, and is required for maintaining the integrity of RBC and lens of eyes.
A. Glutathione
B. Vasopressin
C. Encephalin
D. Oxytocin
E. Retinol

A

Glutathione

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101
Q

Which of the following is true about the central dogma of molecular biology?
A. Genetic information found in DNA is copied and transmitted to daughter cells through DNA replication.
B. Transcription is involved in RNA synthesis
C. The code contained in the nucleotide sequence of messenger RNA molecules is translated to complete gene expression.
D. All of these
E. A and B

A

All of these

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102
Q

Which of the following not true about DNA structure?
A. Phosphodiester bonds stabilize the DNA structure
B. In the double helix, the chains are paired in a parallel manner
C. Uracil is always paired with a thymine and a cytosine is always paired with a guanine
D. A and B
E. B and C

A

B and C

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103
Q

A rule which states that “in any sample of DNA, the amount of adenine equals the amount of thymine, the amount of guanine equals the amount of cytosine, and the total amount of purines equals the total amount of pyrimidines.”
A. Zaitsev’s rule
B. Hund’s rule
C. VSEPR rule
D. Chargaff’s rule
E. Markovnikov’s rule

A

Chargaff’s rule

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104
Q

Which of the following structural forms of DNA is right handed?
A. B-DNA
B. Z-DNA
C. A-DNA
D. A and B
E. A and C

A

A and C

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105
Q

Most species of bacteria also contain small, circular, extrachromosomal DNA molecules called plasmids, which may carry genes that convey
A. Antibiotic resistance
B. Antibaterial effect
C. Mutagenic effect
D Antigenicity
E. Transcription

A

Antibiotic resistance

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106
Q

When the two strands of the DNA double helix is separated, each can serve as a template for the replication of a new complementary strand. This produces two daughter molecules, each of which contains two DNA strands with an antiparallel orientation. This describes:
A. Conservative replication
B. Semiconservative replication
C. Dispersive replication
D. Antigenicity
E. Transcription

A

Semiconservative replication

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107
Q

Human topoisomerase II is targeted by:
A. Etoposide
B. Ciprofloxacin
C. Penicillin
D. Vancomycin
E. Chloramphenicol

A

Etoposide

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108
Q

The strand that is being copied in the direction away from the replication fork, and is synthesize discountinuously, with small fragments of DNA being copied near the replication fork.
A. Leading strand
B. Lagging strand
C. RNA primer
D. Single strand
E. Double strand

A

Lagging strand

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109
Q

Which of the following rRNA size particles is not present in prokaryotes?
A. 23S
B. 15S
C. 5S
D. 40S
E. 50S

A

40s

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110
Q

Which nitrogenous base is not present in RNA structure?
A. Cytosine
B. Uracil
C. Thymine
D. Adenine
E. Guanine

A

Thymine

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111
Q

Ribonucletotide contains:
A. Ribose
B. Nitrogenous base
C. Phosphate
D. All of these
E. None of these

A

All of these

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112
Q

Which of the consequence of point mutation is expected to happen in the codon transition of UCA to UCU? Use the genetic code table below for your reference.
A. Silent mutation
B. Missense mutation
C. Nonsense mutation
D. Spontaneous mutation
E. Frameshift mutation

A

Silent mutation

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113
Q

A hereditary disease that primarily affects the pulmonary and digestive systems, most commonly caused by deletion of three nucleotides from the coding region of a gene, resulting in the loss of phenylalanine at the 508th position in the protein encoded by that gene.
A. Cystic fibrosis
B. Crohn’s disease
C. H.pylori infection
D. Ulcerative colitis
E. Chronic obstructive pulmonary disease

A

Cystic fibrosis

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114
Q

This states that the first (5’) base of the anticodon is not as spatially defined as the other two bases. Movement of that first base allows nontraditional base-pairing with the last (3’) base of the codon, thus allowing a single tRNA to recognize more than one codon for a specific amino acid
A. Chargaff’s rule
B. Wobble hypothesis
C. Shine-Dalgamo sequence
D. Semiconservative
E. Chronic obstructive pulmonary disease

A

Wobble hypothesis

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115
Q

Many antimicrobials inhibits protein translation. Which of the following antimicrobials is correctly paired with is mechanism of action?
A. Tetracyclines – inhibits peptidyltransferase
B. Diphtheria toxin – binds to the 30S subunits
C. Puromycin – inactivates EF-2
D. Erythromycin – binds with 50S ribosomal subunits
E. Clindamycin – binds to the 30S ribosomal subunits

A

Erythromycin – binds with 50S ribosomal subunits

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116
Q

The movement of the uncharged tRNA from the P to the E site (before being released), and movement of the peptidyl tRNA from the A to the P site is termed as:
A. Transcription
B. Translation
C. Translocation
D. Transformation
E. Transferrin

A

Translocation

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117
Q

In DNA double helix, which of the following is not true?
A. Guanine base pairs with cytosine
B. Adenine on one chain forms a base pair with uracil on the other chain
C. The chains are antiparallel
D. Each DNA molecule is composed of two polynucleotide chain joined by hydrogen bonds between bases
E. The double-stranded molecule is twisted to form a helix with major and minor grooves

A

Adenine on one chain forms a base pair with uracil on the other chain

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118
Q

Which of the following statements regarding DNA denaturation is incorrect?
A. Alkali can cause DNA breakage
B. Heat can cause DNA separation
C. Heat and alkali can break phosphodiester bonds
D. A and B
E. All of these

A

Heat and alkali can break phosphodiester bonds

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119
Q

In DNA replication, what enzyme acts to prevent the extreme supercoiling of the parental helix that would result as consequence of unwinding at a replication fork?
A. Topoisomerase
B. RNA polymerase
C. Helicases
D. Isomerases
E. Proteolytic enzymes

A

Topoisomerase

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120
Q

Phase of eukaryotic cell cycle involving DNA (replication) synthesis
A. G1 phase
B. G2 phase
C. G0 phase
D. S phase
E. M phase

A

S phase

121
Q

The deficiency results in an inability to salvage hypoxanthine or guanine, from which excessive amounts of uric acid are produced
A. Hurler syndrome/
B. Sanfilippo syndrome
C. Gaucher’s disease
D. Lesch-Nyhan syndrome
E. Forbes’ disease

A

Lesch-Nyhan syndrome

122
Q

Uric acid
A. May be derived from hypoxanthine
B. May be derived from guanine
C. The end product of protein metabolism
D. A and B
E. A, B and C

A

A and B

123
Q

What ribosomal tRNA acts as a binding site of an incoming aminoacyl-tRNA?
A. E site
B. P site
C. A site
D. A and C are correct
E. B and C are correct

A

A site

124
Q

Where is the cellular location of ribosomes?
A. Cytosol
B. Rough endoplasmic reticulum
C. Smooth endoplasmic reticulum
D. A and B
E. B and C

A

A and B

125
Q

A rare hereditary defect of the enzyme system where the cells cannot repair the damage DNA, resulting in extensive accumulation of mutation and, consequently, early and numerous skin cancers.
A. Basal cell carcinoma
B. Psoriasis
C. Xeroderma pigmentosum
D. Necrotizing fasciitis
E. Lepromatous leprosy

A

Xeroderma pigmentosum

126
Q

Which of the following statements best describes carbohydrates?
A. Least abundant organic molecules in nature
B. Provide a significant fraction of the dietary calories for most organisms
C. Structural component of many organisms
D. All of these
E. B and C

A

B and C

127
Q

Which of the following is not a disaccharide?
A. Sucrose
B. Trehalose
C. Cellobiose
D. Mannose
E. Lactose

A

Mannose

128
Q

Which of the following are isomers?
A. Fructose and glucose
B. Glucose and mannose
C. Mannose and galactose
D. All of these
E. A and C

A

All of these

129
Q

The D- and an L-sugar designation of monosaccharide are:
A. Tautomers
B. Enantiomers
C. Monomers
D. Epimers
E. Anomers

A

Enantiomers

130
Q

Alpha-D-glucopyranose and beta-D-glucopyranose are:
A. Enantiomers
B. Diastereomers
C. Anomers
D. A and C
E. B and C

A

Anomers

131
Q

Which of the following polysaccharides is/are derived from plant sources?
A. Cellulose
B. Glycogen
C. Starch
D. All choices are correct
E. A and C

A

A and C

132
Q

Which of the following is not true about lactose?
A. Reducing sugar
B. With alpha-1,4 glycosidic linkage
C. Contains fructose and galactose
D. A and B
E. B and C

A

B and C

133
Q

The final product of carbohydrate digestion is:
A. Glucose
B. Galactose
C. Fructose
D. All of these
E. A and B

A

All of these

134
Q

Which of the following statements is true?
I. Digestion of carbohydrates begins in the mouth
II. Further digestion of carbohydrate by pancreatic enzyme can occur on the small intestine
III. Final carbohydrate digestion by enzymes synthesized by the intestinal mucosa cells
A. I only
B. II only
C. III only
D. I and II
E. I, II and III

A

I, II and III

135
Q

Lactose intolerance is present among:
A. Lactase-deficient people
B. Sucrase-deficient people
C. Isomaltase-deficient people
D. All of these
E. None of these

A

Lactase-deficient people

136
Q

Disaccharides, oligosaccharides and polysaccharides contains monomer sugar units which are linked by what bond?
A. Hydrogen bond
B. Phosphodiester bond
C. Glycosidic bond
D. Disulfide bond
E. Hydrophobic bond

A

Glycosidic bond

137
Q

Which of the following statements best describes glucose?
A. It is a ketose and usually exists as a furanose ring
B. It is a C-4 epimer of galactose
C. It is utilized in biological systems only in the L-isometric form
D. It is a product from dietary starch by the action of alpha-amylase
E. Homopolysaccharides of glucose, formed by the action of glycosyltransferase, are always branched molecules that contain only beta-glycosidic linkages

A

It is a C-4 epimer of galactose

138
Q

Clinitest is a nonspecific test that produce a change in color id urine is positive in reducing substances. Which of the following sugars is not detected by this test?
A. Xylulose
B. Fructose
C. Sucrose
D. Galactose
E. Glucose

A

Sucrose

139
Q

What effect should drugs like acarbose and miglitol have on the digestion of lactose?
A. Lactose intolerant
B. Diarrhea
C. Lactose digestion
D. A and B
E. None of these

A

None of these

140
Q

Catabolic reaction
I. Breakdown of complex molecules
II. Exergonic reactions
III. Exemplified by glycolysis and glycogenolysis
A. I only
B. I and II
C. I and III
D. I, II and III
E. II and III

A

I and II

141
Q

Evaluate the two statements:
(I) Pyruvate is the end product of glycolysis in cells with mitochondria and an adequate supply of oxygen.
(II) the conversion of glucose to lactate is called anaerobic glycolysis because it can occur without the participation of oxygen.
A. Only I is correct
B. Only II is correct
C. I and II are correct
D. I and II are incorrect

A

I and II are correct

142
Q

The enzyme that may add or remove phosphate group of sugar is called:
A. Hexokinase
B. PFK
C. Pyruvate kinase
D. All of these
E. A and C

A

All of these

143
Q

The enzyme that function as a glucose sensor in the maintenance of blood glucose homeostasis.
A. Glucokinase
B. Hexokinase D
C. Fructokinase
D. A and B
E. All of these

A

A and B

144
Q

Glucose-6-phosphate to fructose-6-phosphate conversion requires:
A. Isomerization
B. Carbon removal
C. Water removal
D. Carbon division
E. A and C

A

Isomerization

145
Q

Cleavage of fructose 1,6-biphosphate is made by:
A. Hexokinase
B. Aldolase
C. Enolase
D. Isomerase
E. Pyruvate kinase

A

Aldolase

146
Q

Which of the following involves oxidation-reduction reaction?
A. Glyceraldehyde 3-phosphate to 1,3-biphosphoglycerate
B. PEP to pyruvate
C. Glucose to glucose 6-phosphate
D. DHA to glyceraldehydes
E. Glucose-6-phosphate to fructose-6-phosphate

A

Glyceraldehyde 3-phosphate to 1,3-biphosphoglycerate

147
Q

The kinase enzyme in glycolysis are physiologically reversible, EXCEPT:
A. Hexokinase
B. Type IV hexokinase
C. Pyruvate kinase
D. Phosphoglycerate kinase
E. Phosphofructokinase

A

Phosphoglycerate kinase

148
Q

In glycolysis, what is the role of phosphoglycerate mutase?
A. Shift of the phosphate group from carbon 3 to carbon 2
B. Dehydration of 2-phosphoglycerate
C. Formation of pyruvate producing ATP
D. Oxidation of glyceraldehyde 3 –phosphate
E. Isomerization of dihydroxyacetone phosphate

A

Shift of the phosphate group from carbon 3 to carbon 2

149
Q

What is the second most common cause of enzyme deficiency related non-spherocytic hemolytic anemia?
A. Pyruvate dehydrogenase deficiency
B. Glucose 6-phosphate dehydrogenase deficiency
C. Morquio syndrome
D. Pyruvate kinase deficiency
E. Sickle cell anemia

A

Pyruvate kinase deficiency

150
Q

Anaerobic glycolysis:
I. Pyruvate is the end product
II. Generates 2 ATP per glucose
III. Produces 1 NADH
A. Only I is correct
B. Only II is correct
C. Only III is correct
D. I and III are correct
E. I, II and III are correct

A

Only II is correct

151
Q

What is the major fuel for the TCA cycle?
A. Pyruvate
B. Acetyl CoA
C. PEP
D. Lactate
E. Oxaloacetate

A

Acetyl CoA

152
Q

A person in a fasting state has
I. Increase of blood glucose
II. Increase of release of glucagon
III. Decrease of insulin
A. I only
B. I and II
C. II and III
D. III only
E. I, II and III

A

II and III

153
Q

What is the final pathway where the oxidative metabolism of carbohydrates, amino acids and fatty acids take place?
A. Kreb’s cycle
B. Glycolysis
C. Urea cycle
D. HMP shunt
E. Oxidative phosphorylation

A

Kreb’s cycle

154
Q

Aldol condensation of acetyl CoA and oxaloacetate yields
A. Citrate
B. Isocitrate
C. Fumarate
D. Malate
E. Succinate

A

Citrate

155
Q

The conversion of citrate to isocitrate requires. . .
A. Dehydroganese
B. Aconitase
C. Fumarase
D. Aldolase
E. Kinase

A

Aconitase

156
Q

How much NADH are produced in TCA cycle?
A. 1 NADH
B. 2 NADH
C. 3 NADH
D. 12 NADH
E. 6-8 NADH

A

3 NADH

157
Q

How many ATP molecules are produced from the oxidation of one molecule of acetyl CoA?
A. 6-8 ATPs
B. 12 ATPs
C. 24 ATPs
D. 36-38 ATPs
E. 129 ATPs

A

12 ATPs

158
Q

Which of the following reactions produce NADH?
A. Oxidation and decarboxylation of isocitrate
B. Oxidative decarboxylation of a-ketoglutarate
C. Oxidation of Malate
D. A and B
E. All of these

A

All of these

159
Q

In Kreb’s cycle, How many NADH, FADH2 and GTP are produced in one round of cycle?
A. 2 NADH, 2 FADH2, and 2 GTP
B. 1 NADH, 3 FADH2, and 3 GTP
C. 3 NADH, 1 FADH2, and 1 GTP
D. 3 NADH, 2 FADH2. and 1 GTP
E. 4 NADH, 0 FADH2, and 2 GTP

A

3 NADH, 1 FADH2, and 1 GTP

160
Q

Oxidation of acetyl CoA yields. . .
A. Carbon dioxide
B. Water
C. Glucose
D. A and B
E. A and C

A

A and B

161
Q

The lactid cycle is also known as:
A. Kreb’s cycle
B. Gluconeogenesis
C. Cori’s cycle
D. Urea cycle
E. Water cycle

A

Cori’s cycle

162
Q

Which of the following may serve as precursor for gluconeogenesis?
A. Lactate
B. Glycerol
C. Glucogenic amino acid
D. A and C
E. All of these

A

All of these

163
Q

Seven glycolytic reactions are reversible and are used in the synthesis of glucose from lactate or pyruvate. In glyconeogenesis, however, some reactions are irreversible and must be circumvented by alternate reactions that are energetically favor the synthesis of glucose. This gluconeogenesis reactions include:
I. Carboxylation of pyruvate
II. Decarboxylation of oxaloacetate
III. Dephosphorylation of fructose 1,6-biosphate
IV. Dephosphorylation of gluvose 6-biosphate
A. I and II
B. I and III
C. I, II, and III
D. I, II, III, and IV
E. II, III, and IV

A

I, II, III and IV

164
Q

The synthesis of glucose from pyruvate by gluconeogenesis:
A. Occurs exclusively in the cytosol
B. In inhibited by an elevated level of glucagon
C. Requires participation of biotin
D. Involves lactate as an intermediate
E. Requires the oxidation/reduction of FAD

A

Involves lactate as an intermediate

165
Q

Which one of the following reactions is unique to gluconeogenesis?
A. Lactate – Pyruvate
B. Phosphoenolpyruvate – pyruvate
C. Oxaloacetate – phosphoenolpyruvate
D. Glucoso 6-phosphate – fructose 6-phosphate
E. 1,3-bis-phosphoglycerate – 3-phosphoglycerate

A

Oxaloacetate – phosphoenolpyruvate

166
Q

The main stores of glycogen in the body are found in the:
A. Skeletal muscle
B. Liver
C. Kidney
D. A and B
E. B and C

A

A and B

167
Q

Glycogen is a branched-chain polysaccharide made exclusively from a-D-glucose. Glucose units are mainly linked by:
A. a(1-4) Linkage
B. a(1-6) Linkage
C. B(1-4) Linkage
D. A and B
E. B and C

A

A and B

168
Q

Evaluate the two statements
(1) Glycogenesis is synthesis of glycogen
(2) Glycosis is degradation of glycogen.
A. Only I is correct
B. Only II is correct
C. I and II are correct
D. I and II are incorrect

A

Only I is correct

169
Q

Evaluate the two statements
(1) Glycogenesis accelerates during periods when the body has been well fed
(2) Glycogenesis accelerates during periods of fasting.
A. Only I is correct
B. Only II is correct
C. I and II are correct
D. I and II are incorrect

A

I and II are correct

170
Q

An elevated insulin level results in:
I. Increased glycogenesis
II. Decreased glycogenesis
III. Elevated glucagon (or epinephrine)
A. I only
B. I and II
C. I and III
D. II and III
E. I, II and III

A

I and II

171
Q

Pompe’s disease is
A. Lysosomal storage disease
B. Glycogen storage disease
C. Type II GSD
D. All of these
E. B and C

A

All of these

172
Q

Increased ingestion of glucose leads to:
I. Increased blood glucose
II. Increased glucagon
III. Increased insulin
A. Only I is correct
B. Only II is correct
C. I and II are correct
D. I and II are incorrect

A

Only I is correct

173
Q

A deficiency of the phosphatase causes glycogen storage disease type 1a. This disease results in an inability of the liver to provide free glucose to the body during a fast.
A. Von Gierke’s disease
B. Pompe’s disease
C. Cori’s disease
D. Anderson’s disease
E. McArdle’s disease

A

Von Gierke’s disease

174
Q

Which of the following pairs is incorrect?
A. Type 1b GSD: Cori’s disease
B. Type II GSD: Pompe’s disease
C. Type III GSD: Cori’s disease
D. Type V: McArdle’s disease
E. Type VI: Her’s disease

A

Type 1b GSD: Cori’s disease

175
Q

The most common monosaccharide consumed by humans:
A. Glucose
B. Fructose
C. Ribose
D. Mannose
E. Arabinose

A

Glucose

176
Q

High-fructose corn syrup typically contains:
A. 90% fructose and 10% galactose
B. 55% fructose and 45% glucose
C. 90% fructose and 10% glucose
D. 50% fructose and 50% glucose
E. 55% galactose and 45% glucose

A

55% fructose and 45% glucose

177
Q

What enzyme is deficient from essential fructosuria?
A. Fructokinase
B. Aldolase A
C. Aldolase B
D. Aldolase C
E. Hexokinase

A

Fructokinase

178
Q

What is the major carbohydrate energy source of sperm cells?
A. Glucose
B. Sorbitol
C. Ribose
D. Fructose
E. Mannose

A

Fructose

179
Q

Galactose
I. Major dietary source is milk
II. C-2 epimer with glucose
III. Detected by muric acid test
A. I only
B. I and II
C. I and III
D. II and III
E. I, II and III

A

I and III

180
Q

Following the intravenous injection of lactose into a rat, none of the lactose is metabolized. However, ingestion of lactose leads to rapid metabolism of this disaccharide. The difference in these observations is a result of:
A. Presence of lactose in the serum
B. The absence of hepatic galactokinase
C. The absence of maltase in the serum.
D. The presence of lactase in the intestine
E. None of these

A

The presence of lactase in the intestine

181
Q

Pentose phosphate pathway
A. Hexose monophosphate pathway
B. 6-phosphogluconate pathway
C. Occurs in cytosol
D. All choices are correct.
E. A and C

A

All choices are correct

182
Q

An inherited disease characterized by hemolytic anemia cause by the inability to detoxify oxidizing agents.
A. Glucose 6-phosphate dehydroganese deficiency
B. Glucose 6-phosphate deficiency
C. Gaucher’s disease
D. Krabbe’s disease
E.Glycogen storage disease

A

Glucose 6-phosphate dehydrogenase deficiency

183
Q

In preparation for a trip to an area of India where malaria is epidemic, A young man is given primaquine prophylactically. Soon thereafter, He develops a hemolytic condition. The most likely cause of the hemolysis is a less-than-normal level of which of the following?
A. Glucose 6-phosphate
B.Oxidized form of NAD
C. Reduced form of glutathione
D. Ribose 5-phosphate
E. Ribulose 5-phosphate

A

Reduced form of glutathione

184
Q

These are long, unbranched, hetero polysaccharide chains generally composed of a repeating disaccharide unit.
A. Glycoproteins
B. Glycosaminoglycans
C. Metaloproteins
D. Lipopolysaccharides
E. Carbohydrates

A

Glycosaminoglycans

185
Q

The most abundant glycosaminoglycans (GAGs) in the body
A. Chondroitin sulfate
B. Keratin sulfates
C. Hyaluronic acid
D. Dematan sulfates
E. Herapin

A

Chondroitin sulfate

186
Q

Which of the following pairs is correct about muccpolysaccharidoses (MPS)?
A. Hurler syndrome: MPS I
B. Hunter syndrome: MPS II
C. Sly syndrome: MPS III
D. A and B
E. B and C

A

A and B

187
Q

Muccpolysaccharidoses are inherited lysosomal storage diseases. They are caused by:
A. An increased rate of synthesis of the carbohydrate component of proteoglycans
B. The synthesis of polysaccharides with an altered structure.
C. Defects in the degradation of GAGs in the proteoglycans
D. The synthesis of abnormally small amounts of protein cones
E. An insufficient of proteolytuc enzymes

A

Defects in the degradation of GAGs in the proteoglycans

188
Q

Which of the following is a cellular defense against reactive oxygen species (ROS)?
A. Superoxide dismutase
B. Catalase
C. Glutathione peroxidase
D. A and B
E. A, B and C

A

A, B and C

189
Q

Evaluate the two statements (1) Conversion of FMN to FMNH2 requires oxidation (2)
Conversion of NADH to NAD+ requires reduction.
A. Only I is correct
B. Only II is correct
C. I and II are correct
D. I and II are incorrect

A

I and II are incorrect

190
Q

A theory that explains how the free energy generated by the transport of electricity by the electron transport chain is used to produce ATP from ADP + Pi
A. Chemiomotic theory
B. Mitchell hyphothesis
C. Archimedis law
D. Noyes-whitney equation
E. A and B

A

A and B

191
Q

In electron transport train, the transport (“pumping”) of protons (H+) across the inner mitochondria membrane from the matrix to the intermembrane space does not happen at:
A. Complex I
B. Complex II
C. Complex III
D. Complex IV
E. A and C

A

Complex II

192
Q

Leber hereditary optic neuropathy is an example of
A. Mitochondrial mutation
B. Nuclear mutation
C. Ribosomal mutation
D. Cytosolic mutation
E. Oxidative mutation

A

Mitochondrial mutation

193
Q

Adenosine Triphosphate
I. Contains the base adenine, the sugar ribose, and three phosphate groups joined each other by two anhydride bonds
II. Produced from adenosine diphosphate(ADP) and inorganic phosphate (Pi) mainly by the process of substrate phosphorylation.
III. Plays a central role in energy exchanges in your body
A. Only I is correct
B. Only II is correct
C. I and II are correct
D. I and II are incorrect

A

I and II are incorrect

194
Q

NADH and/or FADH2 are produced by. . .
A. Glycolysis
B. TCA cycle
C. B-oxidation of fatty acids
D. A and B
E. All of these

A

All of these

195
Q

Which of the following complexes is incorrectly paired?
A. Complex I: NADH dehydroganese
B. Complex II: Succinate dehydroganese
C. Complex III: cytochrome b-c1 complex
D. Complex IV: cytochrome oxidase
E. Complex V: ADP synthase

A

Complex V: ADP synthase

196
Q

For each pair of electrons that enters the chain from NADH, how many protons are pumped out of the mitochondria?
A. 10 protons
B. 6 protons
C. 8 protons
D. 12 protons
E. 24 protons

A

10 protons

197
Q

In electron transport chain, which complex is blocked by either carbon monoxide or cyanide?
A. Complex I
B. Complex II
C. Complex III
D. Complex IV
E. Complex V

A

Complex IV

198
Q

A leading cause of blindness, which is due to, overtime, oxidative damage to the retinal pigment epithelium, such that the brain no longer processes light correctly.
A. Macular degeneration
B. Astigmatism
C. Diplopia
D. Nearsightedness
E. Farsightedness

A

Macular degeneration

199
Q

The following are non-enzymatic antioxidants (free-radical scavengers) EXCEPT:
A. Vitamin E
B. Vitamin C
C. Carotenoids
D. Flavonoids
E. Vitamin K

A

Vitamin K

200
Q

The most potent ROS
A. Hydrogen peroxide
B. Hydroxyl radical
C. Superoxide
D. Coenzyme Q
E. Nitric oxide

A

Hydroxyl radical

201
Q

Metformin is the standard fist-line oral medication for type 2 diabetes. The use of the drug has the potential side effect of lactic acidosis. Which of the following explains why this lactic acid build up is rarely seen clinically?
A. The red blood cells utilize the lactate as fuel.
B. The renal cell utilizes the lactate as fuel
C. The cardiac muscle cells utilize the lactate as fuel.
D. The large, voluntary muscle groups utilize the lactate as fuel.
E. The lactate directly enters the TCA cycle to be oxidized.

A

The cardiac muscle cells utilize the lactate as fuel

202
Q

A contestant on a TV reality show, in which the contestant had to survive off the land for a extended period of time, developed recurrent diarrhea, dermatitis and had trouble remembering things. These symptoms could be brought about due to lack of which one of the following in the contestant’s diet?
A. Niacin
B. Thiamine
C. Riboflavin
D. Vitamin C
E. Vitamin D

A

Niacin

203
Q

The following contains glucose, EXCEPT:
A. Glycogen
B. Triacylglycerol
C. Glycoprotein
D. Glycolipid
E. Ceramide

A

Ceramide

204
Q

Lipid are:
I. Water-insoluble organic molecules
II. Can be extracted from tissues by polar solvent
III. Major source of energy for the body
A. I only
B. I and II
C. II and III
D. I and III
E. I, II and III

A

I and III

205
Q

Which of the following is true with regard to digestion of biomolecules?
A. Protein digestion starts in the mouth
B. Carbohydrate digestion begins in the stomach
C. Lipid digestion begins in the stomach
D. A and B
E. B and C

A

Lipid digestion begins in the stomach

206
Q

What anti-obesity agent inhibits both gastric and pancreatic lipases?
A. Colestipol
B. Simvastatin
C. Orlistat
D. Niacin
E. Gemfibrozil

A

Orlistat

207
Q

Which hormone/s control/s lipid digestion?
I. Insulin
II. Incretin
III. Secretin
IV. Cholescytokinin
A. I and II only
B. II and III only
C. III and IV only
D. I, II and III
E. I, II, III and IV

A

III and IV

208
Q

These are disk shaped clusters of amphipathic lipids that coalesce with their hydrophobic groups on the inside and their hydrophilic groups on the outside.
A. Micelles
B. Aggregates
C. Coalesce
D. Chylomicron
E. Liposomes

A

Micelles

209
Q

A rare, autosomal recessive disorder cause by a deficiency of lipoprotein lipase resulting to chylomicronemia and hypertriacylglycerolemia.
A. Type 1 hyperlipoproteinemia
B. Type IIa familial hypercholesterolemia
C. Familial dysbetalipoproteinemia
D. Familial hypertriglyceridemia
E. Tangier disease

A

Type 1 hyperlipoproteinemia

210
Q

Which of the following fatty acids is a dietary essential in normal humans?
A. Linolenic acid
B. Linoleic acid
C. Arachidonic acid
D. A and B
E. B and C

A

A and B

211
Q

Which of the following contains omega-3 on its structure?
A. Linolenic acid
B. Linoleic acid
C. Arachidonic acid
D. Palmitic acid
E. Arachidic acid

A

Linolenic acid

212
Q

A teenager, concerned about his weight, attempts to maintain a fat-free diet for a period of several weeks. If his ability to synthesize various lipids were examined, he would be found to be most deficient in his ability to synthesize:
A. Triacylglycerol
B. Phospholipids
C. Cholesterol
D. Sphingolipids
E. Prostaglandins

A

Prostaglandins

213
Q

The oxidation of a molecule of palmitoyl CoA to CO2 and H2O produces:
A. 8 acetyl CoA,7 NADH and 7 FADH2
B. 16 acetyl CoA, 16 NADH and 16 FADH2
C. 7 acetyl CoA, 8 NADH and 8 FADH2
D. 8 acetyl CoA, 8 NADH and 8 FADH2
E. 7 acetyl CoA, 7 NADH and 7 FADH2

A

8 acetyl CoA, 7 NADH and 7 FADH2

214
Q

The major supplier of NADPH for fatty acid synthesis:
A. HMP shunt
B. Pentose phosphate pathway
C. Electron transport chain
D. A and B
E. A, B and C

A

A and B

215
Q

Destruction of fatty acid chain happens in the:
A. Ribosome
B. Smooth endoplasmic reticulum
C. Nucleus
D. Cytoplasm
E. Mitochondrion

A

Smooth endoplasmic reticulum

216
Q

Evaluate the two statements: (1) if a species of acylglycerol is solid at room temperature, it is called a “fat” (2) if liquid, it is called an “oil”.
A. Only 1 is correct
B. Only 2 is correct
C. Both 1 and 2 are correct
D. Both 1 and 2 are incorrect

A

Both 1 and 2 are correct

217
Q

The yield from the complete oxidation of fatty acids to CO2 and H2O
A. 9 kcal/g
B. 4kcal/g
C. 7.1kcal/g
D. 3.4 kcal/g
E. None of these

A

9 kcal/g

218
Q

The most common inborn error of fatty acid oxidation
A. medium chain fatty acyl CoA dehydrogenase (MCAD) deficiency
B. Carnithine deficiency
C. Methylmalonyl CoA mutase deficiency
D. Zellweger syndrome
E. X-linked adrenoleukodystrophy

A

medium chain fatty acyl CoA dehydrogenase (MCAD) deficiency

219
Q

Acetoacetate, 3-hydroxybutyrate, and acetone are example of:
A. Ketone bodies
B. Ketogenic amino acids
C. Glucogenic amino acids
D. Ketose sugar
E. Aldose sugar

A

Ketone bodies

220
Q

Excessive production of ketone bodies in diabetes mellitus leads to:
A. Ketonemia
B. Ketonuria
C. Ketoacidosis
D. A and B
E. A, B and C

A

Ketoacidosis

221
Q

Phospholipids
I. Amphipathic
II. Have hydrophilic bond
III. Have a hydrophobic tail
A. Only I is correct
B. I and II are correct
C. I, II and III are correct
D. Only III is correct
E. I, II and III are correct

A

I, II and III are correct

222
Q

Phospholipids that contain glycerol are called:
A. Glycerophospholipids
B. Phosphoglycerides
C. Glycealdehydes
D. Glycerin phosphate
E. A and B

A

A and B

223
Q

Which of the following is correctly paired?
I. Serine + PA -> phosphatigylserine
II. Ethanolamine + PA -> cephalin
III. Choline + PA -> lecithin
IV. Inositol + PA -> phosphatidylinositol
A. I and IV
B. I and II
C. II and III
D. I, II and III
E. I, II, III, and IV

A

I, II, III and IV

224
Q

A long chain fatty acid attached to the amino group of sphingosine through an amide linkage is known as:
A. Ceramide
B. Cerebroside
C. Ganglioside
D. Sulfatide
E. Lipopolysaccharide

A

Ceramide

225
Q

What is the role of phosphatidylcholine in the lungs?
A. Surfactant
B. Prevents osmosis
C. Antimicrobial
D. Neurotransmitter
E. All of these

A

Surfactant

226
Q

Two molecules of phophatidic acid connected by amolecule of glycerol
A. Lecithin
B. Inositol
C. Cardiolipin
D. Cephalin
E. Phosphatidylethanolamine

A

Cardiolipin

227
Q

Glucocorticoid (for example,cortisol) inhibit:
A. Phospholipase A1
B. Phospholipase A2
C. Phospholipase C
D. Phospholipase D
E. Fatty acyl CoA transferase

A

Phospholipase A2

228
Q

An autosomal recessive disease caused by in the inability to degrade sphingomyelin leading to severe mental retardation and neurodegeneration and death in early childhood.
A. Nieman-pick disease
B. Farber’s disease
C. Farby’s disease
D. Gaucher’s disease
E. Tay-sach’s disease

A

Nieman-pick disease

229
Q

Which of the following is not present in lactosylceramide?
A. Sphingosine
B. Fatty acid
C. Glucose
C. Galactose
E. Ganglioside

A

Ganglioside

230
Q

The most common lysosomal storage disease
A. Niemann-pick disease
B. Farber disease
C. Farby’s disease
D. Gaucher’s disease
E. Tey-sach’s disease

A

Gaucher’s disease

231
Q

The following are eicosanoids, EXCEPT:
A. Prostaglandin
B. Thromboxanes
C. Leukotrienes
D. Palmitic acid
E. Arachidonic acid

A

Palmitic acid

232
Q

Which of the following is correct with regarding prostaglandin?
I. Regulate smooth muscle contraction
II. Regulate blood vessel diameter
III. Mediator of inflammatory response
IV. Stimulate gastric acid synthesis
A. I only
B. I and II
C. I, II and III
D. I and III
E. I,II,III and IV

A

I, II and III

233
Q

Evaluate the two statement:
(1) linolenic acid is a dietary precursor of prostaglandin.
(2) arachidonic acid is a immediate precursor of the predominant class of prostaglandin.
A. 1 is correct, 2 is incorrect
B. 1 is incorrect, 2 correct
C. 1 and 2 are correct
D. 1 and 2 are incorrect

A

I and II are incorrect

234
Q

Two isoenzyme of PGH synthase are known. Which is the inducible form?
A. COX 1
B. COX 2
C. LOX
D. A and B
E. A and C

A

COX 2

235
Q

Which of the following NSAIDs is a specific inhibitor of COX-2 isoenzyme?
A. Aspirin
B. Indomethacin
C. Phenylbutazone
D. Celecoxib
E. Mefenamic acid

A

Celecoxib

236
Q

Which of the following is correct about leukotrienes?
I. Mediators of allergic response and inflammation
II. Their synthesis is affected bu NSAIDs
III. Aspirin-induced asthma is a response to overproduction to leukotrienes with NSAID use
A. I and II
B. I and III
C. III only
D. II and III
E. I, II, and III

A

I and III

237
Q

The use of celecoxib to increase the risk of:
A. Hypertension
B. Heart attack
C. Kidney failure
D. Atherosclerosis
E. Diabetes mellitus

A

Heart attack

238
Q

Aspirin-induced asthma (AIA) is a severe reaction to nonsteroidal anti-inflammatory drugs (NSAIDs) characterized by bronchoconstriction 30 minutes to several hours after ingestion. It is seen in as many as 20 % of adults. Which of the following statements best explains the symptoms seen in patients with AIA?
A. NSAIDs inhibit the activity of the CFTR protein, resulting in thickened secretion that block airways.
B. NSAIDs inhibit COX but not lipoxygenase, resulting in the flow of arachidonic acid to leukotriene synthesis.
C. NSAIDs activates the COX activity of PGH synthase, resulting in increased synthesis of prostaglandins that promote vasodilation.
D. NSAIDs activate phospholipases, resulting in decreased amounts of dipalmytoylphosphatidycholine and alveolar collapse.
E. NSAIDs inhibit both COX and LOX enzyme and the asthma attack is due to allergic response to various antigens.

A

NSAIDs inhibit COX but not lipoxygenase, resulting in the flow of arachidonic acid to leukotriene synthesis.

239
Q

The following are true about cholesterol, EXCEPT:
A. Cholesterol is a structural component of all cell membrane
B. Cholesterol is a precursor of bile acids and vitamin C.
C. Liver plays a central role in the regulation of the body’s cholesterol homeostasis.
D. Cholesterol is the major sterol in animal tissues.
E. All of these

A

Cholesterol is a precursor of bile acids and vitamin C

240
Q

What is the rate-limiting enzyme and the major control point for cholesterol biosynthesis?
A. HMG CoA reductase
B. Decarboxylase
C. Kinase
D. Transferase
E. Isomerase

A

HMG CoA reductase

241
Q

Cholelithiasis is a:
A. Kidney failure condition
B. Cholesterol storage disease
C. Cholesterol gallstone disease
D. Cholesterol degradation failure
E. Heart problem

A

Cholesterol gallstone disease

242
Q

A patient with Type 1 hyperlipoproteinemia is deficient in:
A. Lipoprotein lipase
B. HMG-CoA synthase
C. HMG-CoA reductase
D. L-carnithine
E. Apo B

A

Lipoprotein lipase

243
Q

Which of the following lipoproteins contains the highest amount of triacylglycerol?
A. Chylomicron
B. HDL
C. LDL
D. VLDL
E. IDL

A

Chylomicron

244
Q

A patient with Type II hyperlipidemia is expected to have an increase in:
A. LDL
B. Cholesterol
C. TAG
D. A and B
E. A, B, and C

A

A and B

245
Q

An increase in plasma HDL is correlated to a/an:
A. Decrease risk of atherosclerosis
B. Increase risk atherosclerosis
C. No significant effect in arthrosclerosis
D. Increase chance of CHD
E. Increase chance of Tangier disease

A

Decrease risk of atherosclerosis

246
Q

What precursor is present in glucocorticoids, mineralocorticoids, and sex hormone?
A. Monosaccharides
B. Prostanioc acid
C. Isoprene units
D. Cholesterol
E. Purine/pyrimidines

A

Cholesterol

247
Q

What hormone is labeled as “stress hormone”?
A. TSH
B. ACTH
C. LH and FH
D. Prolactin
E. Vasopressin

A

ACTH

248
Q

Aldosterone’s primary effect:
I. Increase glucose uptake
II. Increase sodium uptake
III. Increase potassium excretion
IV. Increase blood pressure
A. I and II
B. II and III
C. II and III
D. II, III and IV
E. I, II, III and IV

A

II, III and IV

249
Q

Carl Derrick, 35y/o male was seen in the emergency room because of recurrent abdominal pain. The history revealed a 2-year pattern of pain in the upper right quadrant, beginning several hours after the ingestion of meal rich in fried/fatty food. Ultrasonographic examination demonstrated the presence of numerous stones in the gallbladder. The patient initially elected treatment consisting of exogenously supplied chenodeoxycholic acid, but eventually underwent surgery for the removal of the gallbladder, and had a full recovery. The rationale for the initial treatment of this patient with chenodeoxycholic acid is that this compound:
A. Interferes with enterohepatic circulation
B. Inhibits cholesterol synthesis
C. Increases de novo bile acid production
D. Increase cholesterol solubility in the bile
E. Increase the hydrophobicity of gallstones

A

Increase cholesterol solubility in the bile

250
Q

Which lipoproteins deliver dietary (exogenous) TAG to peripheral tissues?
A. HDL
B. LDL
C. Chylomicron
D. VLDL
E. IDL

A

Chylomicron

251
Q

Activator of lipoprotein lipase
A. Apoprotein CII
B. Apoprotein B48
C. Apoprotein A1
D. Apoprotein E
E. Apoprotein B100

A

Apoprotein CII

252
Q

Major carriers of triacylglycerols
A. LDL
B. VLDL
C. Chylomicron
D. A and B
E. B and C

A

B and C

253
Q

The formation of lipid-rich plagues in the intima of arteries
A. Gout
B. Cornea arus accumulation
C. Atherosclerosis
D. Farber’s disease
E. Tangler disease

A

Atherosclerosis

254
Q

In terms of density, arrange the following lipoproteins in descending order:
I. Chylomicrons
II. LDL
III. VLDL
IV. IDL
V. HDL
A. I-II-III-V-IV
B. I-III-II-IV-V
C. V-IV-III-II-I
D. V-II-IV-III-I
E. V-I-II-IV-III

A

V-II-IV-III-I

255
Q

Patients with Familial lipoprotein lipase (LDL) deficiency (chylomicronemia) is treated with:
A. Niacin
B. Diet
C. Gemfibrozil
D. Simvastatin
E. Cholestyramine

A

Diet

256
Q

Fatty acids, which are the major source of energy in the human body, are oxidized mainly by:
A. Beta-oxidation
B. w-oxidation
C. a-oxidation
D. peroxisomal oxidation
E. none of these

A

Beta-oxidation

257
Q

A patient with high blood cholesterol levels was treated with Lovastatin. This drug lowers blood cholesterol levels due primarily to which one of the following?
A. inhibition of absorption of dietary cholesterol
B. inhibition of lipoprotein lipase in adipose tissue
C. inhibition of citrate lyase in the liver
D. inhibition of HMG-CoA reductase in the liver and peripheral tissues
E. induction of LDL receptors in the liver and peripheral tissues

A

inhibition of HMG CoA reductase in the liver and peripheral tissues

258
Q

Type 1 diabetes mellitus is caused by a decrease ability of the B-cells of the pancreas to produce insulin. A person with Type 1 diabetes mellitus who has neglected to take insulin injection will exhibits which one of the following?
A. Increased fatty acid synthesis from glucose in liver
B. Decreased conversion of fatty acids to ketone bodies
C. Increased stone of triacylglycerol in adipose tissue
D. Increased production of acetone
E. Increased glucose transport into muscle cells

A

Increased production of acetone

259
Q

Shannon, a 2 day-old infant born at 32 weeks gestation has had breathing difficulties since birth and is currently on a respirator and 100% oxygen. These difficulties occur due to which one of the following?
A. An inability of the lungs to contract to exhale
B. An inability of the lungs to expand when taking in air
C. An inability of the lung to respond to insulin
D. An inability of the lungs to respond to glucagon
E. An inability of the lungs to produce energy

A

An inability of the lungs to expand when taking in air

260
Q

Biological effects of insulin:
I. Increase glucose uptake
II. Increase glycogenolysis
III. Increase protein synthesis
IV. Increase fat synthesis
A. I and II
B. I,II and III
C. I, III, and IV
D. III and IV
E. I,II,III and IV

A

I, III and IV

261
Q

Biological effects of glucagon
I. Increase glucose uptake
II. Increase glycogenolysis
III. Increase protein synthesis
IV. Increase fat synthesis
A. I and II
B. I, II and III
C. I, III, and IV
D. III and IV
E. I, II, III and IV

A

I, III and IV

262
Q

Which of the following oppose/s the many actions of insulin?
I. Glucagon
II. Epinephrine
III. Cortisol
IV. Growth hormone
A. I and II
B. I and III
C. I, II and III
D. II and III
E. I, II, III and IV

A

I, II, III and IV

263
Q

Which of the following is not considered a essential component of the diet but may provide a significant contribution to the daily caloric intake of some individuals?
A. Carbohydrate
B. Protein
C. Essential fatty acid
D. Ethanol
E. Miinerals

A

Ethanol

264
Q

Consumption of fats containing w-6 polyunsaturated fatty acid PUFAs:
A. Increase HDL levels
B. decrease LDL level
C. Decrease HDL level
D. A and B
E. B and C

A

B and C

265
Q

True statement about trans fatty acid include:
I. Unsaturated fatty acid
II. Elevate serum LDL
III. Elevate serum HDL
IV. Increase the risk of CHD
A. I and II
B. I, II and III
C. II and III
D. I, II and IV
E. I, II, III and IV

A

I, II and IV

266
Q

Correct statement about nitrogen balance include:
I. Positive nitrogen balance occur when nitrogen intake exceeds nitrogen excretion
II. Negative nitrogen balance occurs when nitrogen loses are greater than nitrogen intake.
III. Negative nitrogen balance is observed in situations in which tissue growth occurs.
IV. Positive nitrogen balance is associated with inadequate dietary protein
A. I and II
B. II and III
C. III and IV
D. I, II and III
E. I, II, III, and IV

A

I and II

267
Q

Given the information that a 70-kg man is consuming a daily average of 275g of carbohydrate, 75g of protein, and 65g of lipid, how many kilocalories are generated?
A. 415kcal
B. 1985 kcal
C. 3,410 kcal
D. 1950 kcal
E. 4,310 kcal

A

1985 kcal

268
Q

Where in the body the carotenoids are converted to vitamin A?
A. Liver
B. Kidney
C. Muscles
D. Brain
E. Intestine

A

Liver

269
Q

Which of the following fat soluble vitamins has a coenzyme function?
A. Vitamin A
B. Vitamin C
C. Vitamin K
D. Vitamin D
E. Vitamin E

A

Vitamin K

270
Q

Macrocytic nutritional anemia:
I. Deficiency in folate
II. Deficiency in Vitamin B12
III. Iron deficiency anemia
IV. Protein-energy malnutrition
A. I and II
B. II and III
C. III and IV
D. I, II and III
E. I, II, III and IV

A

I and II

271
Q

A condition in which the blood has a lower than normal concentration of hemoglobin, which results in reduced ability to transport oxygen.
A. Anemia
B. Hypoxia
C. Methemoglobinemia
D. Erythropoietic protoporhyria
E. Cyanosis

A

Anemia

272
Q

What is the most common form of nutritional anemia?
A. Iron-deficiency anemia
B. Pernicious anemia
C. Thallassemia
D. Megaloblastic anemia
E. Pernicious anemia

A

Iron deficiency anemia

273
Q

The most common neural tube defect is:
A. Spina bifida
B. Anencephaly
C. Microcephaly
D. A and B
E. B and C

A

A and B

274
Q

Vitamin B12 is synthesized only by:
A. Microorganisms
B. Plants
C. Animals
D. A and B
E. B and C

A

Microorganisms

275
Q

Megaloblastic anemia is due to deficiency of:
A. Vitamin B9
B. Vitamin B12
C. Vitamin B15
D. A and C
E. A and B

A

Vitamin B9

276
Q

A severe malabasorption of vitamin b12 leads to
A. Pernicious anemia
B. Iron deficiency anemia
C. Sickle cell anemia
D. Aplastic anemia
E. Polycythemia vera

A

Pernicious anemia

277
Q

Vitamin C:
I. Active form of vitamin c
II. An oxidizing agent
III. Coenzyme on hydroxylation ractions
IV. Facilitates the absorption of dietary iron
A. I and II
B. III and IV
C. I, II, and III
D. I, III and IV
E. I, II, III and IV

A

I, III and IV

278
Q

Anti-oxidant vitamin include:
I. vitamin c
II. Vitamin a
III. Vitamin D
IV. Vitamin E
A. I and II
B. I and III
C. I, II, and III
D. I, II and IV
E. I, II, III and IV

A

I, II and IV

279
Q

The only water soluble vitamin with significant toxicity
A. Vitamin B1
B. Vitamin C
C. Vitamin B6
D. Vitamin B9
E. Vitamin B2

A

Vitamin B6

280
Q

Thiamine deficiency with is seen primarily in association with chronic alcoholism
A. Beriberi
B. Scurvy
C. Wernicke-Korsakoff syndrome
D. Hemorrhage
E. RBC fragility

A

Wernicke-Korsakoff syndrome

281
Q

Dermatitis, diarrhea and dementia are classic symptoms of what vitamin deficiency?
A. Vitamin B1
B. Vitamin B2
C. Vitamin B3
D. Vitamin B6
E. Vitamin B9

A

Vitamin B3

282
Q

Niacin effect on lipids:
I. decrease LDL
II. Decrease VLDL
III. Decrease TAG
IV. Decrease HDL
A. I and II
B. I, II and III
C. II, III and IV
D. I and III
E. I, II, III and IV

A

I, II and III

283
Q

Dermatitis, chellosis and glossitis are symptoms of which vitamin deficiency?
A. Vitamin B1
B. Vitamin B2
C. Vitamin B3
D. Vitamin B4
E. Vitamin B5

A

Vitamin B2

284
Q

The addition of raw egg white to the diet as a source of protein induces symptoms of biotin deficiency, namely, dermatitis, glossitis, loss of appetite, and nausea. What component of raw egg white tightly binds biotin and prevents its absorption from the intestine?
A. Collagen
B. Avidin
C. Albumin
D. Glianin
E. Albuminoid

A

Avidin

285
Q

What vitamin is a component of Coenzyme A (CoA, which functions in the transfer of acyl groups?
A. Vitamin B1
B. Vitamin B2
C. Vitamin B3
D. Vitamin B5
E. Vitamin B6

A

Vitamin B5

286
Q

Which vitamin A forms is useful in dermatology?
A. Retinol
B. Retinal
C. Beta-carotene
D. Retinoic acid
E. Retinyl ester

A

Retinoic acid

287
Q

Isotretinoin
I. 13-cis-retinoic acid
II. Treatment of promylelocytic leukemia
III. Useful in severe, recalcitrant cystic acne
A. I only
B. II only
C. III only
D. I and II
E. I, II and III

A

I, II and III

288
Q

Function of vitamin D, EXCEPT:
A. Increasing uptake of calcium by the intestine
B. Increasing loss of calcium by the kidney
C. Stimulating resorption of bone
D. A and B
E. B and C

A

Increasing loss of calcium by the kidney

289
Q

Vitamin K is required in the hepatic synthesis of prothrombin and blood clotting factors II, VII, IX, and X. Which drug antagonizes the action of Vitamin K?
A. Aspirin
B. Ibuprofen
C. Heparin
D. Warfarin
E. Clopidogrel

A

Warfarin

290
Q

The least toxic of the fat-soluble vitamins
A. Vitamin A
B. Vitamin D
C. Vitamin C
D. Vitamin E
E. Vitamin K

A

Vitamin E

291
Q

Vitamin K deficiency is common in:
A. Newborn
B. Adult male
C. Adult female
D. Adolescent
E. Geriatric patients

A

Newborn

292
Q

Vitamin k
A. plays a essential role om preventing thrombosis
B. increases the coagulation time in newborn infants wth hemorrhagic disease
C. is present in high concentration in cow or breast milk
D. is synthesized by intestinal bacteria
E. is a water-soluble vitamin

A

is synthesized by intestinal bacteria

293
Q

Deficiency of peroximal PhyH (phytanoyl-CoA a-hydroxylase)
A. Refsum disease
B. Zellweger syndrome
C. Trisomy syndrome
D. Lysosomal storage disease
E. Klinefeiter syndrome

A

Refsum disease

294
Q

Which of the following biochemical reactions does not happen in the mitochondria?
A. Kreb cycle
B. Fatty acid synthesis
C. Lipoprotein synthesis
D. Beta-oxidation
E. Heme synthesis

A

Lipoprotein synthesis

295
Q

People who suffer from binges of overeating, followed by self-induced vomiting to avoid gaining weight have a condition called:
A. Anorexia nervosa
B. Bulimia
C. Stress eating disease
D. Anemia
E. A and B

A

Bulimia

296
Q

The observable traits of the individuals produced by the interaction of the genes and the environment
A. Phenotype
B. Genotype
C. Genes
D. Allele
E. Locus

A

Phenotype

297
Q

Turner syndrome
A. Trisomy 13
B. Trisomy 18
C. Trisomy 21
D. Monosomy X
E. XYY

A

Monosomy X

298
Q

The genetic composition of the individual
A. Phenotype
B. Genotype
C. Heritability
D. Penetrance
E. Variable expressivity

A

Genotype

299
Q

Which of the following is correctly paired?
I. Point mutations: a change in one bases of the DNA
II. Deletions: a loss of bases in the DNA
III. Insertions: new DNA sequence added into existing DNA
IV. Extra copy of an allele: trisomy for an autosomal chromosome
A. I and II
B. II and III
C. I and IV
D. I, II and III
E. I, II, III and IV

A

I, II, III and IV