Induction Flashcards
Propofol Dose + Trade Name
Diprivan
Induction: 1.5 - 2.5 mg/kg
Maintenance:
- Sedation 25 - 100 mcg/kg/min
- TIVA 100 - 300 mcg/kg/min
Etomidate Dose + Trade Name
Amidate
0.3 mg/kg
Ketamine Dose + Trade Name
Ketalar
Induction: 0.5 - 1.5 mg/kg
Maintenance:
Analgesia- 0.2-0.5 mg/kg IV or
4-8 mg/kg IM
Midazolam Induction Dose
0.1 - 0.2 mg/kg
Propofol Onset
30 - 60 secs
Propofol Duration
1 - 8 minutes
Etomidate Onset
1 min
Ketamine Onset
1 min
Ketamine Duration
10 - 20 min
Midazolam Induction Duration
5 - 10 min
Propofol MOA
GABA agonist; selectively modulates GABA(a) receptors
Increases: CHLORIDE conductance
Hyperpolarization of the postsynaptic cell membrane and functional inhibition of the postsynaptic neuron
Etomidate MOA
Selective modulator of GABAa receptors (need GABA present)
Only carboxylated imidazole-containing *No analgesia
Ketamine MOA
non-competitively binds to the phencyclidine site inside the NMDA receptor and blocks the influx of calcium, resulting in a decrease in the presynaptic release of glutamate
Weak GABA a receptor action
Other receptor sites: opioid (μ, δ, and κ; weak σ)
Propofol Pharmacodynamics
Metabolism: 60% Hepatic, 40% Renal, Pulmonary (clearance)?
Other Considerations: egg yolk allergy (lecithin), caution in dec EF & hypotension
Ketamine Pharmacodynamics
Metabolism: Hepatic, cytochrome P450 enzymes
Other Considerations: Emergence delirium, mAChR antagonist (secretions), Increases ICP, & Caution if catecholamine depletion
