Pharmacology of Asthma Flashcards
what is the MOA of salbutamol?
agonist for B2 receptor on airway smooth muscle cells
reduces Ca2+ entry
prevents smooth muscle contraction
what is the drug target for salbutamol?
beta-2 adrenergic receptor on smooth muscle cells
what are the main side effects for salbutamol?
palpitations
tachycardia
arrhythmias
hypokalaemia at high doses
what class of drug is salbutamol?
SABA - short acting beta agonist
what is the MOA of fluticasone?
multiple actions on diff cells via glucocorticoid receptor
directly decreases inflammatory cells e.g eosinophils, monocytes, mast cells, macrophages, DCs
reduces cytokine release from these cells
what is the drug target for fluticasone?
glucocorticoid receptor
what are the local side effects for fluticasone?
sore throat
hoarse voice
opportunistic oral infections
what are the systemic side effects of fluticasone?
growth retardation in children
hyperglycaemia
decreased bone mineral density
immunosuppression
effects on mood
what is the MOA for mometasone?
multiple actions on diff cells
directly decreases inflammatory cells e.g eosinophils, monocytes, mast cells, macrophages, DCs
reduces cytokine release from these cells
what is the MOA for budesonide?
multiple actions on diff cells
directly decreases inflammatory cells e.g eosinophils, monocytes, mast cells, macrophages, DCs
reduces cytokine release from these cells
what is the drug target for mometasone?
glucocorticoid receptor
what is the drug target for budesonide?
glucocorticoid receptor
which drug out of fluticasone, mometasone and budesonide is less potent?
budesonide
what is the MOA of montelukast?
CysLT1 leukotriene receptor antagonist on eosinophils, mast cells and airway smooth muscle cells
causes decreased eosinophil migration, broncho-constriction and inflammation induced oedema
what is the drug target of montelukast?
CysLT1 leukotriene receptor