Test # 4 Sex Hormones

Question 1

What forms of estrogen are produced and secreted by the ovaries

Answer 1

Estradiol and Estrone

Question 2

What form of estrogen is also made in the adrenal gland and other organs for males

Answer 2

Estrone

Question 3

What is the most commonly used HRT that has an increase rish of uterine cancer but now has progestin to limit endometral hyperplasia

Answer 3

Medroxyprogesterone acetate (MPA)

Question 4

A SERM that is used to treat B Ca. bc it blocks the estrogen receptor in breast cells.

contridicated in pt with endometral cancer

Answer 4

Tamoxifen

Question 5

a SERM that treats B. Ca and helps treat osteoprosis also.

2x at risk for DVT and PE

Answer 5

Raloxifene

Question 6

A drug that blocks all estrogen (weak agonist and strond estrogen antagonist)

It is used for infertility (induction of ovulation)

SE: ovarian cysts and multiple births

Also a drug that does the same but is a complete estrogen agonist

Answer 6

Clomiphene

Fulvestrant

Question 7

What are 3 types of progesterone that interacts with the PR

it helps establish and maintain a pregnancy

also a oral contraceptive

Answer 7

Prometrium
Crinone
Progestasert

Question 8

What drug can be used in the first trimester to terminate a pregnancy? It is also a contraceptive.

contraindicated in pt with asthma and vag bleeding

Answer 8

Mifepristone

Question 9

a first gen contraceptive drug that has to used with ethinyl estradiol to be able to metabolize it

Answer 9

Mestranol

Question 10

a 2nd gen contraceptive drug that is very common and is a progestin

Answer 10

Norethindrone

Question 11

a 3rd generation contraceptive drug that is more potent than estranes and is the safest and lowest SE

Answer 11

Desogestrel

Question 12

what are the 2 drugs that are used in the monophasic formulation of contraceptives. They maintain a fixed level of hormones for 21 days and 7 days of hormone-free pills

Answer 12

Mestranol and Norethindrone

Question 13

what are the 2 drugs that are used in the Biphasic formulation of contraceptives. They have a lower concentration for 7days and then higher for the next 14 = this limits the exposure to progestin

Answer 13

Ethinyl estradiol and Norethindrone

Question 14

what are the 2 drugs that are used in the the triphasic formulation of contraceptives. They have fix concentraions of one with three different levels of another

Answer 14

ethinyl estradiol and norethindrone or gonanes

Question 15

What are three drugs that are contraceptives that are only pregestin!
Good for women smokers

Oral, IM, sub dermal, and IUD

Answer 15

Northindrone
Levonorgestrel
Medroxyprogesterone

Question 16

An emergency contraceptive but must be taken within 72 hours of intercourse.
It does not harm established pregnancies

Answer 16

Levonorgestrel

Question 17

What is the combo therapy for contraception that is a 91 day course of pills - only 1 period every three months?

Answer 17

Levonorgestrel and ethinyl estradiol

Question 18

If you have a hx of emboli, MI, stroke, decreased liver fx, Br Ca. vag bleeding, pregnancy, and smokers over 35 y.o. - you can absolute not take

Answer 18

Contraceptive drugs

Question 19

What are the two primary androgens that are synthesized from cholesterol

Answer 19

testosterone and dihydrotesterone

Question 20

What are two testosterone drugs that are used to treat hyopgonadism in adult males.

Answer 20

Histerone and Androgens

Question 21

What are two androgen receptor antagonist that are used to treat Prostate cancer and hirsutism in women (facial hair)

Answer 21

Flutamide and Bicalutamide

Question 22

What is a 5-alpha reductase inhibitor (androgen antagonist) that is used to treat benign prostate cancer and male pattern baldness

Answer 22

Finasteride