Proteins Flashcards

1
Q

provides ___ of daily body energy

A

12-20%

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2
Q

___ of a cell’s dry weight

A

50-70%

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3
Q

+ and - acute phase reactants

A

+ = increase in concentration // -= decrease in concentration (inflammation)

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4
Q

linear sequence of amino acids

A

primary structure

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5
Q

determines the identity of proteins

A

primary structure

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6
Q

Winding of polypeptide chain. Refers to the
specific 3D configuration of the ɑ-helix and
β-pleated sheets (bent form)

A

secondary structure

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7
Q

Actual 3D configuration of proteins or the
folding pattern of protein

A

tertiary structure

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8
Q

Responsible for many of the physical and
chemical properties of the protein

A

tertiary structure

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9
Q

Association of two or more polypeptide chain to form a functional protein molecule

A

quaternary structure

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10
Q

Albumin does not have a _____, it is a ______

A

quaternary, single polypeptide chain

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11
Q

Catalyzes chemical reactions

A

enzymes

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12
Q

Chemical messengers that control the action
of specific cells or organs

A

hormones

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13
Q

Affect the growth, metabolism, and
development of the body

A

hormones

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14
Q

Transport movement of ions, small
molecules, or macromolecules across a
biological membrane

A

transport proteins

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15
Q

Immunoglobulins are produced by _________ in the
___________ that mediate the humoral
immune response to identify and neutralize
foreign objects.

A

B cells (lymphocytes), bone marrow

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16
Q

storage form of iron

A

ferritin

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17
Q

plasma proteins that function in the
distribution of water throughout the
compartments of the body

A

osmotic force

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18
Q

contains peptide chain of amino acid

A

simple proteins

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19
Q

Symmetrical, water soluble

A

globular protein

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20
Q

Transporter enzyme and
hormone/messenger

A

globular protein

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21
Q

examples of globular protein

A

albumin, hemoglobin,
immunoglobulin

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22
Q

Long filament, asymmetrical, usually
inert

A

fibrous protein

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23
Q

Water insoluble

A

fibrous protein

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24
Q

Provides structure to the
cell

A

fibrous protein

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25
Q

examples of fibrous protein

A

fibrinogen, troponin,
collagen

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26
Q

consists of protein and a
non-protein group

A

conjugated proteins

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27
Q

examples of metalloproteins

A

– ferritin, ceruloplasmin,
hemoglobin, flavoproteins

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28
Q

examples of glycoprotein

A

haptoglobin, α1-antitrypsin
(10-40% CHO)

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29
Q

examples of lipoproteins

A

VLDL, LDL, HDL, Chylomicrons

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30
Q

examples of mucoproteins

A

mucin

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31
Q

examples of nucleoprotein

A

chromatin

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32
Q

Most commonly analyzed protein

A

plasma proteins

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33
Q

Generally function as transporter

A

albumin group

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34
Q

Groupings are based on _____
depending on their migration on the electrophoresis

A

electrophoretic mobility

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35
Q

Maintains osmotic pressure and as an amino acid
reserve

A

albumin group

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36
Q

Aka Transthyretin

A

pre albumin

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37
Q

Migrates before albumin in electrophoresis

A

pre albumin

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38
Q

Indicator of nutritional status

A

pre albumin and albumin

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39
Q

Binds thyroid hormones and retinol

A

pre albumin

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40
Q

Used to confirm the specimen is CSF

A

pre albumin

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41
Q

half life of pre albumin

A

2 days

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42
Q

increased prealbumin

A

alcoholism, chronic renal failure, steroid
treatment

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43
Q

decreased prealbumin

A

poor nutrition

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44
Q

Reference value and CF of prealbumin

A

18-45 mg/dL (CF to mg/L: 10)

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45
Q

electrolytes transported by albumin

A

Ca, Mg, Fe

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45
Q

The most abundant protein in plasma

A

albumin

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46
Q

decreased in albumin

A

inflammation, liver disease, renal disease

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47
Q

of albumin is synthesized by the liver per day

A

9-12g

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48
Q

reference value and CF of albumin

A

3.5-5.0 g/dL (CF: 10)

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49
Q

albumin conjugates with (4)

A

bilirubin, thyroid hormones, aspirin, fatty acids

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50
Q

Included in assessing the synthetic function
of liver

A

albumin

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51
Q

Sensitive and prognostic marker of cystic
fibrosis

A

albumin

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52
Q

Indicator of short-term hyperglycemic
control

A

albumin

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53
Q

Compensate to the loss of albumin resulting to
normal level of total protein

A

globulin group

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54
Q

Most abundant protein (__%)
in the α1-globulin band

A

a1-antitrypsin, 90%

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55
Q

Major inhibitor of protease
activity

A

a1-antitrypsin

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56
Q

Neutralizes trypsin-like
enzymes

A

a1-antitrypsin

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57
Q

the primary neutrophilic granule that
combats infection but may also destroy pulmonary alveoli
resulting to emphysema

A

neutrophil elastase

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58
Q

increased a1-antitrypsin

A

inflammation,
pregnancy and contraceptive
use

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59
Q

decreased a1-antitrypsin

A

emphysema,
juvenile hepatic cirrhosis,
SERPINA1 gene mutation

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60
Q

reference value and CF of a1-antitrypsin

A

145-270 mg/dL (CF to g/L: 0.01)

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61
Q

Migrates between albumin and
α1 globulin band

A

a1-fetoprotein

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62
Q

a1-fetoprotein is synthesized by the ____ and then by the fetal
______ of the liver

A

fetal yolk sac, parenchymal cells

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63
Q

a1-fetoprotein is normally detected in maternal
serum during the _______
of pregnancy

A

7-8th month

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64
Q

methods of a1-fetoprotein

A

immunochemical
test, Radioimmunoassay,
Enzyme Linked immunoassay

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65
Q

increased a1-fetoprotein

A

Maternal serum (twin
fetus)
Peaks in fetus at 13th
week of gestation
Serum: hepatoma
(>1000 ng/mL)
Gonadal cancer

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66
Q

gestational marker for
neural tube defect, spina
bifida, and fetal distress

A

a1-fetoprotein

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67
Q

decreased a1-fetoprotein

A

Down
Syndrome, Edward’s syndrome

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68
Q

reference value of a1-fetoprotein

A

5 ng/mL

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69
Q

Aka Orosomucoid

A

a1-acid glycoprotein

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70
Q

Contains high levels of
carbohydrates (__%) and sialic
acid (____%)

A

a1-acid glycoprotein, 45%, 11-12%

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71
Q

Major plasma glycoprotein

A

a1-acid glycoprotein

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72
Q

Diagnostic tool for neonatal
bacterial infections

A

a1-acid glycoprotein

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73
Q

Binds progesterone and
quinidines

A

a1-acid glycoprotein

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74
Q

increased a1-acid glycoprotein

A

pregnancy, cancer,
pneumonia, AMI, RA and cell
proliferation

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75
Q

methods for a1-acid glycoprotein

A

Radial
immunodiffusion,
immunoturbidity,
nephelometry, immunofixation

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76
Q

reference value and CF of a1-acid glycoprotein

A

50-120 mg/dL
(CF to g/L: 0.01)

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77
Q

Member of the serine protease
inhibitor (serpin) family

A

a1-antichymotrypsin and inter-a-trypsin inhibitor

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78
Q

Binds and inactivates prostate
specific antigens

A

a1-antichymotrypsin

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79
Q

Pathognomonic of Alzheimer’s
disease

A

a1-antichymotrypsin

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80
Q

Integral component of the
amyloid deposits in Alzheimer’s
disease

A

a1-antichymotrypsin

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81
Q

increased in a1-antichymotrypsin

A

infection,
malignancy, burn, AMI,
Alzheimer’s disease

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82
Q

decreased in a1-antichymotrypsin

A

: liver disease

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83
Q

reference value and CF of a1-antichymotrypsin

A

: 30-60 mg/dL
(CF to g/L: 0.01)

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84
Q

Plays an important role in
inflammation and
carcinogenesis.

A

inter-a-trypsin inhibitor

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85
Q

increased in inter-a-trypsin inhibitor

A

inflammatory
disorders

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86
Q

Indirect marker for
atherosclerosis

A

a-lipoprotein

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86
Q

a-lipoprotein - Increased ( ____mg/dL):
________
Decreased ( mg/dL): _______

A

≥65, cardioprotective // <35, risk for
chronic heart disease, acute
myocardial infarction

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87
Q

main function of Gc globulin

A

Vitamin
D-binding protein

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87
Q

method of Gc globulin

A

radial
immunodiffusion

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88
Q

It is the major carrier protein
for Vitamin D and its
metabolites

A

Gc globulin

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89
Q

Transports fatty acids and
endotoxins

A

Gc globulin

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90
Q

Migrates towards the α1 and α2
bands (EPS)

A

Gc globulin

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91
Q

increased in Gc globulin

A

pregnancy (3rd
trimester), oral contraceptives
(estrogen)

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92
Q

decreased in Gc globulin

A

liver disease

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93
Q

reference value and CF of Gc globulin

A

20-55 mg/dL
(CF to g/L: 0.01)

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94
Q

A tetramer

A

haptoglobin

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95
Q

Binds free hemoglobin by its α chain

A

haptoglobin

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96
Q

marker for intravascular hemolysis

A

haptoglobin

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97
Q

Marker to evaluate rheumatic disease

A

haptoglobin

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98
Q

increased in haptoglobin

A

stress,
myoglobinuria

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99
Q

decreased in haptoglobin

A

Intravascular
hemolysis,
hemoglobinuria

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100
Q

methods of haptoglobin

A

radial
immunodiffusion,
immunonephelometry

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101
Q

reference value and CF of haptoglobin

A

26-185
mg/dL (CF to g/L: 0.01)

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102
Q

Copper-binding glycoprotein

A

ceruloplasmin

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103
Q

Synthesized by the liver where 6-8
atoms of copper are attached

A

ceruloplasmin

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104
Q

Marker for Wilson’s Disease

A

ceruloplasmin

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105
Q

deposition of copper in cornea

A

Kayser Fleisher rings

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106
Q

increased in ceruloplasmin

A

inflammation,
cancer, pregnancy

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107
Q

decreased in ceruloplasmin

A

Wilson’s
disease, malnutrition,
malabsorption, nephrotic
disease, Menkes’
Syndrome
(kinky hair)

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107
Q

reference value & CF of ceruloplasmin

A

18-45
mg/dL (CF to mg/L: 10)

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108
Q

method for ceruloplasmin

A

Copper oxidase
activity

109
Q

largest major non-immunoglobulin

A

a2-macroglobulin

109
Q

proteases inhibited by a2-macroglobulin

A

trypsin, thrombin,
kallikrein, plasmin

110
Q

Forms a complex with PSA

A

a2-macroglobulin

111
Q

Removed by reticuloendothelial system after inhibiting proteases

A

a2-macroglobulin

112
Q

reference value and CF of a2-macroglobulin

A

150-420
mg/dL (CF to g/L: 0.01)

112
Q

increased in a2-macroglobulin

A

Nephrosis (10x),
Pregnancy (20%),
Diabetes, Liver disease,
Contraceptive medication

112
Q

methods for a2-macroglobulin

A

radial
immunodiffusion,
immunonephelometry,
ELISA and latex
agglutination

113
Q

proteins in a1 globulin group

A

a1-antitrypsin, a1-fetoprotein, a1-acid glycoprotein, a1-antichymotryspsin, inter-a-trypsin inhibitor, a-lipoprotein, Gc globulin

114
Q

a2 globulin group

A

haptoglobin, ceruloplasmin, a2-macroglobulin

114
Q

proteins in b2 globulin group

A

hemopexin, b2-microglobulin, transferrin, fibrinogen, complement, c-reactive protein, pre-b-lipoprotein, b-liporotein, immunoglobulins

115
Q

binds heme released by degeneration of hemoglobin

A

hemopexin

116
Q

reference value & CF of hemopexin

A

50-120 mg/dL (CF: 0.01)

116
Q

increased in hemopexin

A

inflammation, diabetes, duchenne-type muscular dystrophy, melanoma

117
Q

decreased in hemopexin

A

urinary loss, decrease liver synthesis, hemolytic anemia, intravascular hemolysis

118
Q

light chain component in the major histocompatibility complex or human leukocyte antigen

A

b2-microglobulin

119
Q

found in the surface of most nucleated cells

A

b2-microglobulin

119
Q

found in high level concentration in lymphocytes

A

b2-microglobulin

119
Q

important in the production of CD8 cells

A

b2-microglobulin

120
Q

freely filtered by the glomerulus and absorbed & metabolized in the proximal tubules in the kidneys

A

b2-microglobulin

121
Q

increased _______ in plasma is due to impaired clearance in the kidneys

A

b2-microglobulin

122
Q

tends to fold into b-sheet configuration

A

b2-microglobulin

122
Q

increased in b2-microglobulin

A

renal disease, multiple myelomas, RA, SLE, HIV

123
Q

method for b2-microglobulin

A

immunoassay

123
Q

reference value for b2-microglobulin

A

0.2 - 2.8 ug/dL

124
Q

negative acute phase reactants

A

albumin and transferrin

125
Q

major b-globulin protein

A

transferrin

126
Q

other name of transferrin

A

siderophilin

127
Q

transports iron back to its storage site (___)

A

transferrin, bone marrow

128
Q

increased level of transferrin in plasma appears as ___ (__) and is seen in severe IDA

A

paraprotein (pseudoparaproteinemia)

129
Q

decreased level of transferrin can impair _____ and can lead to _____

A

hgb production, anemia

130
Q

increased transferrin

A

hemochromatosis (bronze diabetes), IDA

131
Q

decreased transferrin

A

liver disease, malnutrition, nephrotic syndrome

132
Q

methods for transferrin

A

immunodiffusion, immunonepehelometry

133
Q

reference value for transferrin

A

Male: 215-365 mg/dL // Female: 250-380 mg/dL // CF: 0.01

134
Q

other name for fibrinogen

A

clotting factor I

135
Q

one of the largest proteins in the blood

A

fibrinogen

136
Q

most abundant coagulation factor

A

fibrinogen

137
Q

marker for long term prognosis of cardiovascular disease

A

fibrinogen

138
Q

increased fibrinogen

A

inflammatory disorders, pregnancy, contraceptive medication

139
Q

decreased fibrinogen

A

extensive coagulation

140
Q

reference value and CF for fibrinogen

A

200-400 mg/dL (0.01)

141
Q

natural defense mechanism against infection

A

complement

142
Q

ciruclates in inactivated form

A

complement

143
Q

most abundant complement in serum

A

C3

144
Q

important in macular degeneration

A

C3

145
Q

most commonly measured complement protein

A

C3 AND C4

146
Q

increased in complement

A

inflammation

147
Q

important in assessing RA and SLE

A

C4 & C4

148
Q

decreased in C3

A

autoimmune disorders, neonatal respiratory distress syndrome, bacteremia, tissue injury, chronic hepatitis

149
Q

decreased in C4

A

disseminated intravascular coagulation, acute glomerulonephritis, chronic hepatitis, hemolytic anemia, malnutrition

150
Q

method of complement

A

immunonephelometry, turbidimetry

151
Q

member of the pentaxin protein family

A

C-reactive protein

152
Q

most popular acute phase reactant

A

C-reactive protein

153
Q

name is derived for the ability to precipitate C-substance of pneumococci

A

C-reactive protein

154
Q

known as a scavenger molecule

A

C-reactive protein

155
Q

gamma-migrating protein

A

C-reactive protein

156
Q

early cardiac marker

A

C-reactive protein

157
Q

used as a rapid test and presumptive diagnosis of bacterial or viral infection

A

C-reactive protein

157
Q

determines the severity of CHD

A

C-reactive protein

158
Q

undetectable in healthy specimen, but is present in diverse inflammatory disease

A

C-reactive protein

159
Q

increased in C-reactive protein

A

acute rheumatic fever, myocardial infarction, RA, gout, bacterial & viral infection

160
Q

reference value of C-reactive protein

A

> 1.0 mg/dL

161
Q

transports TAG from liver to peripheral tissues

A

pre-b-lipoprotein

162
Q

transports cholesterol from liver to peripheral tissues

A

b-lipoprotein

163
Q

most atherogenic lipoprotein

A

b-lipoprotein

164
Q

reference values for b-lipoprotein

A

Optimal: <100mg/dL // Above optimal: 100-129 mg/dL // Borderline: 130-159 mg/dL // High: 160-189 mg/dL // Very high: > _190mg/dL

165
Q

the only protein synthesized by plasma cells

A

immunoglobulins

166
Q

most abundant, found in plasma and lymph nodes

A

IgG

167
Q

found in mucous secretions

A

IgA

167
Q

1st to appear in resposnse to antigenic stimulation

A

IgM

168
Q

found in the surface of B cells

A

IgD

169
Q

associated with allergy and anaphylactic shock

A

IgE

169
Q

composition of immunoglobulins (%)

A

82-96% protein // 4-18% CHO

170
Q

gamma spike is seen in?

A

multiple myeloma, immunoglobulins

171
Q

decreased immunoglobulins

A

HIV and other immunodeficiences

172
Q

method for immunoglobulins

A

nephelometry, turbidimetry, radial immunodiffusion, immuno assay

173
Q

primary oxygen-carrying protein

A

myoglobin

174
Q

what are the cardiac proteins

A

myoglobin, troponin, b-type natriuretic peptide

175
Q

myoglobin is found in

A

cardiac and skeletal muscle

176
Q

myoglobin carries ___% of total muscle protein

A

2%

177
Q

myoglobin transports and stores oxygen from ____ to the intracellular respiratory enzymes of the ________

A

hgb, contractile cells

178
Q

earliest marker for myocardial infarction

A

myoglobin

179
Q

rise of myoglobin

A

1-3hrs

180
Q

peak of myoglobin

A

5-12hrs

181
Q

troponin is found in

A

skeletal muscle

182
Q

normalize of myoglobin

A

18-30 hrs ave. 24 hrs

183
Q

transporter of actin and myosin

A

troponin

184
Q

method of troponin

A

immunoassay

185
Q

screening test for myocardial infarction (____)

A

myoglobin, >100 ug/mL

186
Q

myoglobin may cause false positive in urine strip and Hgb during ______ due to its ______

A

myoglobinuria, pseudoperoxidase activity

187
Q

myoglobin increased

A

AMI, rhabdomyolysis, angina, muscular trauma, intramuscular injection, strenous exercise, acute renal failure

188
Q

method of myoglobinuria

A

immunoassay

189
Q

other name of troponin T

A

troponin-binding subunit

190
Q

other name of troponin I

A

inhibitory subunit

191
Q

other name of troponin C

A

calcium-binding subunit

192
Q

troponin that regulates muscle contraction

A

troponin c

193
Q

troponin that is cardiac specific and sensitive

A

troponin i

194
Q

troponin that is not cardiac specific

A

troponin c

195
Q

troponin i is found in

A

myocardium

196
Q

troponin that is absent in normal serum

A

troponin i and t

197
Q

troponin t is found in

A

fetal and deceased skeletal muscle

198
Q

sensitive marker for diagnosis of unstable angina

A

troponin t

199
Q

_____ - suggestive of AMI

A

> _1.5 ng/mL

200
Q

rise, peak, normalize of troponin t

A

3-4hrs, 10-24hrs, 7 days

201
Q

rise, peak, normalize of troponin i

A

3-6hrs, 12-18hrs, 5-10 days

202
Q

popular marker for congestive heart failure

A

b-type natriuretic peptide

203
Q

increases in response to peptide ventricular systolic and diastolic dysfunction

A

b-type natriuretic peptide

204
Q

half life of b-type natriuretic peptide

A

60-120 minutes

205
Q

methods for b-type natriuretic peptide

A

RIA, microparticle enzyme immunoassay, ECLIA

206
Q

reference value of b-type natriuretic peptide

A

<100pg/mL

207
Q

other name for renal proteins

A

cystatin c

208
Q

alternative for creatinine and creatinine clearance test to screen and monitor kidney dysfunction

A

renal proteins

208
Q

a cysteine proteinase inhibitor

A

renal proteins

209
Q

new sensitive endogenous serum marker for glomerular filtration rate

A

renal proteins

210
Q

not affected by age, diet, gender, or muscle mass

A

renal proteins

211
Q

increased in renal proteins

A

renal disease

212
Q

what are the renal proteins

A

urinary proteins, microalbuminuria, csf protein, csf oligoclonal banding

212
Q

methods for renal proteins

A

particle-enhanced immunoturbidimetry, immunonephelometry

213
Q

most urinary proteins are from the ____

A

blood

214
Q

normal albumin excretion rate

A

<20 ug/min

215
Q

most common and serious type of proteinuria

A

glomerular proteinuria (albuminuria)

216
Q

appearance
of low molecular weight proteins
in urine due to defective
reabsorption with slightly
increased urine albumin excretion
rate

A

tubular proteinemia

217
Q

positive albumin dipstick value

A

> _6.0 mg/dL

218
Q

hemoglobinuria, myoglobinuria,
and Bence-Jones Proteins

A

overload proteinemia

219
Q

protein
from the urinary tract caused by
infection, bleeding, or malignancy

A

postrenal proteinemia

220
Q

Early indicator of glomerular
dysfunction

A

microalbuminuria

221
Q

Nephropathy associated with
Type 1 DM

A

microalbuminuria

222
Q

positive for microalbuminuria

A

2 out 3 specimens collected
within 3-6 months

223
Q

physiologic increase for microalbuminuria

A

physical exercise during the previous 24 hours

224
Q

specimen for microalbuminuria

A

random urine

225
Q

increased in microalbuminuria

A

diabetic nephropathy,
fever, infection and hypertension

226
Q

method for microalbuminuria

A

random-spot
albumin-creatinine ratio

227
Q

reference value for microalbuminuria

A

0-29 μg/mg creatinine
Microalbuminuria: 30-300
μg/mg creatinine.
Clinical albuminuria: >300
μg/mg creatinine

228
Q

an ultrafiltrate of plasma
formed in the choroid plexus
of the ventricles of the brain

A

CSF

229
Q

method for CSF protein

A

TCA, SSA, Coomassie
Brilliant Blue (dye), Lowry and
Kinetic Biuret Reaction

230
Q

decreased in CSF protein

A

intracranial
hypertension, hyperthyroidism,
CSF leakage due to trauma

231
Q

reference value of CSF protein

A

15-45 mg/dL

232
Q

reference value of CSF albumin

A

10-30 mg/dL (2/3 of
CSF total protein)

233
Q

Presence of 2 or more IgG
bands in the γ region

A

CSF Oligoclonal banding

234
Q

Seen in multiple sclerosis (90%)

A

CSF Oligoclonal banding

235
Q

(+) result for CSF Oligoclonal banding

A

≥ 2 bands in
the CSF not present in serum

236
Q

other disorders with 2 or more bands in the CSF

A

Encephalitis, neurosyphilis,
Guillain-Barre syndrome,
neoplastic disorders

237
Q

supporting medium & stain for CSF Oligoclonal banding

A

Agarose gel & Coomasie Brilliant
Blue

237
Q

Disorders with serum banding
appearing in CSF

A

Leukemia, lymphoma, viral
infection

238
Q

Detected in newborn screening

A

aminoacidopathies

238
Q

what is absent in alkaptonuria

A

homogentisate-1,2-dioxygenase

239
Q

diagnostic indicator of alkaptonuria

A

darkening
of urine upon standing at RT

239
Q

clinical feature of alkaptonuria

A

ochronosis
(tissue pigmentation)

240
Q

what is absent in homocystinuria

A

cystathionine Β-synthase

241
Q

what is absent in Maple Syrup Urine Disease

A

α-keto
acid decarboxylase

241
Q

screening test & antagonist of homocystinuria

A

Modified Guthrie Test (Lmethionine sulfoximine – antagonist)

242
Q

Result from accumulation of
branched-chain amino acids such as

A

leucine, isoleucine, & valine

243
Q

clinical features of homocystinuria

A

physical
defects, thrombosis,
osteoporosis, islets
abnormalities, and mental
retardation

244
Q

screening test & antagonist of Maple Syrup Urine Disease

A

Modified Guthrie Test (4-azaleucine – antagonist)

245
Q

diagnostic test for Maple Syrup Urine Disease

A

amino acid analysis (HPLC)

245
Q

indicator of Maple Syrup Urine Disease

A

4 mg/dL leucine – indicative of MSUD

246
Q

clinical feature of Maple Syrup Urine Disease

A

failure to thrive,
muscular rigidity, mental
retardation, hypoglycemia

247
Q

what is absent in Phenylketonuria

A

phenylalanine hydrolase
(PAH) / phenylalanine-4-
monooxygenase

248
Q

reference value of PKU

A

1.2-3.4 mg/dL (70-200 umol/L)

249
Q

PKU displays increased concentration
of primary metabolite
(_______) in both
blood & urine

A

phenylpyruvic acid

250
Q

odor of PKU urine

A

Musty odor urine

251
Q

screening test for PKU

A

Guthrie
Bacterial Inhibition Assay
(Bacillus subtilis spores
& β2-thienylalanine -
antagonist)

252
Q

positive result for screening test of PKU

A

Bacterial
growth (phenylalanine
>4 mg/dL)

253
Q

Tyrosinemia 2

A

Tyrosine
aminotransferase

254
Q

Tyrosinemia 3

A

4-hydroxyphenylpyruvic
acid dioxygenase

255
Q

Tyrosinemia 1

A

Fumarylacetoacetate
hydrolase/FAA
hydrolase

256
Q

Tyrosinemia is accompanied by

A

increased
level in the blood of methionine
& p-hydroxyphenyl pyruvic acid