Pharmacokinetics

Question 1

when a constant amount of a drug is eliminated per unit of time (i.e., 15 mg/hr)
- “0 shows the amount”

Answer 1

zero-order kinetics

Question 2

when a proportion of the drug is eliminated per unit of time (i.e., 50%/hr)
- “First cut in the cake”

Answer 2

first-order kinetics

Question 3

highest concentration of drug in blood stream

Answer 3

peak

Question 4

when serum drug levels in the body remain constant

Answer 4

steady state

Question 5

lowest concentration of drug in the bloodstream

Answer 5

trough

Question 6

time for serum drug concentration to decrease by 50%

Answer 6

half-life

Question 7

increasing dose =

Answer 7

loading dose

Question 8

steady dose =

Answer 8

maintenance dose

Question 9

decreasing dose =

Answer 9

taper dose

Question 10

increases rapidly, then tapers off steadily (solid line) =

Answer 10

loading dose followed by infusion

Question 11

increases rapidly, then tapers off dramatically (small-dashed line) =

Answer 11

bolus dose w/o infusion

Question 12

increases slowly over time (large-dashed line) =

Answer 12

infusion w/o loading dose