synthetic cannabinoids and sympathomimteics

Question 1

Receptors involved and effects

Answer 1

• CB1 (CNS): inc mood euphoria, relaxation, creative thinking, sensory awareness
• CB2 (Periphery): immune modulation, anti-inflammatory

Question 2

Which receptor does THC act on and how

Answer 2

Partial agonist of CB1

Question 3

K2/Spiced Synthetic Cannabinoids pearls and lab abnormalitites

Answer 3

• minor changes in structure = big effects
• labs abnormalities: dec k, inc BG, creatinine kinase, WBC, inc creatinine, WBC,

Question 3

K2/Spiced Synthetic Cannabinoids management

Answer 3

treat symptoms
- agitation: IV/IM lorazepam or Midazolam, antipsychs
- seizures: IV/IM lorazepam or diazepam, IM midazolam
- n/v
- dehydration - iv crystalloids
- HTN/tachy - IM/IV benzos

Question 4

What is Cannabinoids Hyperemesis Syndrome and the moa

Answer 4

• excessive vomiting due to chronic use
• MOA dysregulation of endocannabionoid system, altered TRPV1 receptors
  -happens month-years of continuous marijuana smoking

Question 5

Management of Cannabinoids Hyperemesis Syndrome

Answer 5

• Hot showers + Capsaicin topical cream (activated TRPV1)
• Antinausea: Haloperidol > Ondansetron
• Benzos
• Fluids, electrolytes

Question 6

Sympathomimetics aka Uppers substances

Answer 6

• Cocaine, Amphetamines, Bath Salts, Pseudoep, Nootropics

Question 7

Sympathomimetics MOA

Answer 7

• MOA: inh NE + DA reuptake, or inc release of neurotransmitters

Question 8

Sympathomimetics S/S

Answer 8

• Inc everything, including seizures + tremors

Question 9

Sympathomimetics Treatment

Answer 9

Supportive Care
- Activated charcoal
- high dose benzos
- antihypertensives
- fluids
- antipsychs
- ice baths
- sodium bicarb

Question 10

what are aes of sympathomimetics

Answer 10

• hyperthermia
• rhabdomyolysis
• dysrhythmias