Thyroid + Pituitary Drugs

Question 1

The hypothalamus

Question 2

Name the differences between the APG and PPG

Answer 2

Posterior releases ADH and oxytocin, anterior produces “-H” hormones: ACTH, FSH, GH, LH, PH, TSH

Question 3

“-pressin” drugs act on the ________ ________.

Answer 3

posterior pituitary

Question 4

Cosyntropin, somatropin, and octreotide are _________ ________ drugs.

Answer 4

anterior pituitary

Question 5

if some was diagnosed w/ adrenocortical insufficiency, what would they be prescribed? How would you describe the drug’s MOA?

Answer 5

-consyntropin
-tells the APG to tell the adrenal cortex to make more cortisol

Question 6

Somatropin is lowkey a rich people drug. Why? Side effects?

Answer 6

-it stimulates skeletal growth–made for pt w/ deficient growth hormone, but rich ppl use it to make their kids taller
-those rich little kids may experience headache, rash, high BG

Question 7

Ocreotide works to to ____ ______ growth by acting on the ______ _______ gland.

Answer 7

-slow down
-anterior pituitary

Question 8

Vasopressin mimics ____, increasing ___. Side effects include…

Answer 8

-ADH
-BP
-N/V, heartburn, fever, headache

Question 9

Vasopressin is a potent ___________ used for hypotensive emergencies like _____ _______ or pulseless cardiac arrest

Answer 9

-vasoconstrictor
-septic shock

Question 10

The thyroid secretes what three hormones for metabolic regulation?

Answer 10

-T4
-T3
-calcitonin

Question 11

What are the symptoms of hypothyroidism vs hyperthyroidism?

Answer 11

-hypo: feels too cold, thick skin, fatigue, hair loss, weight gain, constipation
-hyper: feels too hot, diarrhea, increased appetite, flushing, sleep issues, nervousness

Question 12

Thyroid replacement meds (levothyroxine, liothyronine, liotrix) considerations

Answer 12

-empty stomach
-takes 3-4 weeks to kick in
-caution when switching brands
-dosed in mcg
-can cause severe cardiac events

Question 13

Treatment for hypothyroidism must be _________ in early pregnancy

Answer 13

continued

Question 14

Propylthiouracil and Tapazole are used to treat _________. What’s the MOA? (hint: think salt..) Side effects?

Answer 14

-prop/tap –> hyperthyroidism.
-MOA: inhibit iodine –> tyrosine transformation
-SFX: liver/bone marrow toxic, drowsy/headache/NV

Question 15

levothyroxine, liothyronine, and liotrix mimic ___ and ___ hormones to treat _______.

Answer 15

-T4, T3 (respectively)
-hypothyroidism