E3. HLD r2 Flashcards

1
Q

Atorvastatin 40-80 mg

A

High Intensity Statin

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2
Q

Atorvastatin 10-20 mg

A

moderate-intensity statin

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3
Q

Rosuvastatin 20-40 mg

A

High Intensity Statin

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4
Q

Rosuvastatin 5-10 mg

A

Moderate-Intensity Statin

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5
Q

Simvastatin 20-40 mg

A

Moderate Intensity Statin

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6
Q

Pravastatin 40-80 mg

A

Moderate-Intensity Statin

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7
Q

Lovastatin 40 mg

A

Moderate Intensity Statin

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8
Q

Fluvastatin 80 mg

A

Moderate Intensity Statin

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9
Q

Pitavastatin 2-4 mg

A

Moderate Intensity Statin

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10
Q

Pleiotropic Effects of Statins

A
  1. Improve Endothelial Function
  2. Atherosclerotic plaque stabilization
  3. Decrease oxidative stress and inflammation
  4. Inhibit Thrombogenic response.
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11
Q

Simvastatin 10 mg

A

Low-Intensity Statin

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12
Q

Pravastatin 10-20 mg

A

Low-Intensity Statin

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13
Q

Lovastatin 20 mg

A

Low-Intensity Statin

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14
Q

Fluvastatin 20-40 mg

A

Low-Intensity Statin

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15
Q

Pitavastatin 1 mg

A

Low-Intensity Statin

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16
Q

Active Liver Disease
Unexplained elevated transaminases (3x ULN)
Pregnant or Nursing Women
Major Drug Interactions

A

Statin Contraindications.

17
Q

Pravastatin and Rosuvastatin

A

Hydrophillic Statins

18
Q

Atorvastatin, Lovastatin, and Simvastatin

A

CYP3A4 substrates

19
Q

Atorvastatin, Pitavastatin, and Rosuvastatin

A

Long Half-Lives.

20
Q

Statin Benefit Groups.

A
  1. 40-75 w/ 70-190 LDL no DM
  2. LDL >190 mg/dL
  3. Diabetes
  4. Secondary Event
21
Q

Non-Statin Benefit Group (possibly primary prevention)

A
  1. LDL >160 mg/dL
  2. History of premature ASCVD
  3. High CRP (>2 mg/dL)
22
Q

Categorize This Risk Category.

  1. Progressive ASCVD after achieving LDL <70
  2. Established CVD w/ DM, CKD, HeFG
  3. History of premature ASCVD (<55 (m), <65 (F)
A

Extreme Risk

23
Q

Categorize this risk category.
1. Recent Hospitalization for (ACS, Coronary Disease, PAD)

  1. ASCVD >20%
  2. Diabetes/CKD + 1 Risk Factor
A

Very High Risk

24
Q

Categorize this risk category.

  1. 2+ RF for ASCVD + 10-20% ASCVD risk
  2. Diabetes/CKD w/ no RF.
A

High Risk

25
Q

Extreme Risk LDL Goal

A

<55 mg/dL

26
Q

Very High Risk LDL Goal

A

<70 mg/dL

27
Q

High Risk LDL Goal

A

<100 mg/dL