MSRA: Hepatitis B

Question 1

True or False
Core antibodies persist for life

Answer 1

True

Question 2

True or False
IgM core antibodies indicate chronic infection

Answer 2

False
Indicates acute infection <6 months

Question 3

True or false
Surface antibodies provide lifelong immunity

Answer 3

True

Question 4

Interpret the following Hep B serology results:

HBsAg negative
anti-HBs positive
anti-HBc negative
IgM anti-HBc negative

Answer 4

Immunity by immunisation

Question 5

Interpret the following Hep B serology results:

HBsAg negative
anti-HBs negative
anti-HBc negative
IgM anti-HBc negative

Answer 5

Susceptible

Question 6

Interpret the following Hep B serology results:

HBsAg positive
anti-HBs negative
anti-HBc positive
IgM anti-HBc positive

Answer 6

Acute infection

Question 7

Interpret the following Hep B serology results:

HBsAg negative
anti-HBs negative
anti-HBc positive
IgM anti-HBc negative

Answer 7

Resolved infection

Question 8

Interpret the following Hep B serology results:

HBsAg positive
anti-HBs negative
anti-HBc positive
IgM anti-HBc negative

Answer 8

Chronic infection

Question 9

What action is needed following anti-HBs levels of 10-100?

Answer 9

Sub-optimal response. Give one further vaccination dose

Question 10

What action is needed following anti-HBs levels of <10?

Answer 10

Non-responder. Give further vaccine course (3 further doses)