Diseases of peripheral nervous system Flashcards
What is ddx, hx, PE and Ix for CNS lesions, peripheral nerves, NMJ disorders and muscle diseases?
Define radiculopathy, plexopathy and neuropathy (mononeuropathy, mononeuritis multiplex, polyneuropathy)
□ Radiculopathy involving nerve roots
□ Plexopathy involving nerve plexus
□ Neuropathy involving nerves
→ Mononeuropathy: only one nerve affected
→ Mononeuritis multiplex: multiple sequential mononeuropathies
→ Polyneuropathy: symmetrical involvement of all/most peripheral nerves
How to classify diseases of the peripheral nerves?
What are the clinical features of diseases of the peripheral nerves?
What are the mechanisms of mononeuropathy?
□ Entrapment: damage to a nerve where it passes through a tight space
□ Trauma
□ Other focal lesions, eg. granulomatous inflammation
What are the causes of entrapment mononeuropathy?
What are the causes of mononeuritis multiplex?
What are the causes of polyneuropathy?
What are causes of acute and chronic axonal disease and what are there clinical features?
What are causes of acute and chronic demyelinating disease and what are there clinical features?
What are SS of polyneuropathy?
How to dx according to pattern of SS?
What ddx consideration for polyneuropathy?
What is the workup and Ix done?
What is disease modifying Tx and symptomatic Tx for polyneuropathy?
133 Antiganglioside antibodies (incl. anti-GQ1B, anti-GD3, anti-GM1) are associated with certain forms of GBS.
134 Anti-myelin associated glycoprotein antibodies are found in a rare form of CIDP-like polyneuropathy.
135 Anti-Hu and anti-Yo antibodies are often found in paraneoplastic neuropathies.
What is classical presentation of GBS?
What is associated disease?
What are the types?
What are the clinical features and SS of GBS?
What are the Ix done for GBS?
What is the Mx of GBS?
What is the prognosis?
What are SS of Miller Fisher syndrome?
What Ix?
What ddx?
What Mx?
What is the clinical features of CIDP?
What Ix done?
What is the ddx and Mx for CIDP?
What are causes and examples of hereditary motor and sensory neuropathy?
Causes: genetics (mostly autosomal dominant), pathology: demyelinating, hypomyelination or axonal degenerative
Ex: Charcot Mariet Tooth disease (CMTD), hereditary neuropathy with liability to pressure palsies (HNPP)