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pharmacology > Antifungals > Flashcards

Antifungals Flashcards

1
Q

What agents can you use topically to treat dermatophytes

A

lime sulfar dip
Azoles

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2
Q

What agents are typically used for systemic mycoses

A

azoles
terbenifine
griseofulvin
polyenes
iodines

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3
Q

What is the MoA of griseofulvin

A

arresting cell division, only effective against dermatophytes

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4
Q

What are the adverse effects of griseofulvin

A

bone marrow suppression
GI
poss carcinogen (no food animals)

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5
Q

Which agents can be used against asper

A

polyenes
azoles
terbinofine

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6
Q

What is the most common drug in the polyenes class?

A

amphotericin B

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7
Q

What is the main adverse effect of polyenes

A

nephrotoxicity

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8
Q

What are the most common agents of the azole class?

A

Ketoconazole
Itraconazole
Fluconazole
vorticonazole
miconazole (topical only)

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9
Q

What azole is a CYP450 inhibitor?

A

ketoconazole

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10
Q

What azole is most affective against asper

A

itraconazole

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11
Q

What antifungal is the one of choice for CNS and eye treatment?

A

fluconazole

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12
Q

What is the only antifungal that will enter urine at therapeutic doses?

A

fluconazole

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13
Q

What is the main adverse effect of itrazonazole?

A

hepatotoxicity

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14
Q

What azole is a CYP450 inducer?

A

voriconazole

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15
Q

Which azole is contraindicated in cats?

A

voriconazole

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16
Q

True/False: all azoles are potentially hepatotoxic?

A

true

17
Q

Which antifungal do you really want to avoid use of with liver/renal dysfunction?

A

terbinafine

18
Q

What is terbinafine used for

A

both dermatophytes and systemic mycoses

19
Q

What are iodides used for?

A

actinobacillus lignieressi in cattle

20
Q
A

pharmacology (6 decks)

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