Chapter 1 Quiz

Question 1

Which radionuclides are possible radioactive contaminants in the eluent of Rb82 generator?

-Sr82 and Sr 85
-Sr82 and Zr82
-Zr 82 and Zr85
-Sr82 and Sr87

Answer 1

Sr82 and Sr 85

Question 2

Negative ion PET cyclotrons accelerate which of the following types of particles?

-Protons
-negatively charged hydrogen atoms
-negatively charge neutrons
-negatively charges protons

Answer 2

negatively charged hydrogen atoms

Question 3

F18 labeled to glucose using a chemical method known as _____.

-electrophilic substitution
-base hydrolysis
-mannose triflate hydrolysis
-nucleophilic substitution

Answer 3

nucleophilic substitution

Question 4

The bombarding particles used for the nuclear reactions that occur in a cyclotron must have an energy of at least ____MeV.

3
5
8
10

Answer 4

8

Question 5

The most common irradiation process of producing F18 with a 109.7 minute half-life is ______.

O18 (p,alpha) F18
O16 (p,pn) F18
O16 (p,alpha) F18
O18 (p,n) F18

Answer 5

O18 (p,n) F18

Question 6

According to the US federal regulations, any product with a half-life greater than ____ minutes must pass quality control testing before it can be released for human use.

10
20
30
60

Answer 6

20

Question 7

As specified in the USP, F18-FDG must have chemical purity of greater than ____.
85%
90%
95%
98%

Answer 7

90%

Question 8

Which of the following quality control tests for F18-FDG CANNOT be preformed before patient use?

radiochemical purity
radionuclidic purity
pH
sterility

Answer 8

sterility

Question 9

The initial precursor molecule for producing F18-FDG is _____.

mannose triflate
dibutylboron triflate
trifluoroacetic acid
methyl triflate

Answer 9

mannose triflate

Question 10

Because of the high amount of radioactivity, the production of PET radiopharmaceuticals must be done in lead-shielded hot cells and with an automated system called a ______.

cyclotron
synthesis module
reactor vessel
Kryptofix 222

Answer 10

synthesis module