Applied Pharmacology (Textbook) MCQs

Question 1

Propofol:

a) is suspended in an emulsion of soyabean oil and egg phosphatide
b) can produce green urine
c) has little effect on the cardiovascular system
d) impairs ventilatory response to CO2
e) has no effect on intraocular pressure.

Answer 1

a) is suspended in an emulsion of soyabean oil and egg phosphatide

b) can produce green urine
d) impairs ventilatory response to CO2

Question 2

The following are safe in porphyria:

a) morphine
b) sulphonamides
c) chlorpromazine
d) barbiturates
e) diazepam

Answer 2

a) morphine
c) chlorpromazine
e) diazepam

Question 3

If 50% nitrous oxide is inhaled for 3 days:

a) the lymphocyte count falls
b) methionine synthetase activity is reduced
c) megaloblastic bone marrow changes occur
d) B12 deficiency anaemia develops
e) peripheral neuropathy develops.

Answer 3

b) methionine synthetase activity is reduced
c) megaloblastic bone marrow changes occur

Question 4

Halothane hepatotoxicity is linked to:

a) age
b) obesity
c) prolonged anaesthesia
d) a history of cholecystitis
e) hypoxia

Answer 4

b) obesity
e) hypoxia

Question 5

Isoflurane:

a) has a similar boiling point to enflurane
b) has a similar saturated vapour pressure to halothane
c) has a lower blood/gas coefficient than halothane
d) is extensively metabolised
e) has a MAC of 0.56% in oxygen

Answer 5

b) has a similar saturated vapour pressure to halothane

c) has a lower blood/gas coefficient than halothane

Question 6

Cerebral vascular resistance is reduced by:

a) halothane
b) enflurane
c) isoflurane
d) trichloroethylene (trilene)
e) thiopentone

Answer 6

a) halothane
b) enflurane
c) isoflurane
d) trichloroethylene (trilene)

Question 7

Methohexitone:

a) has a pH less than 8 in 1% solution
b) is a methylated thiobarbiturate
c) has a longer duration of action than thiopentone
d) does not cause pain on injection
e) is associated with fewer excitatory phenomena than thiopentone

Answer 7

NONE of the answers are correct!

Question 8

Increase in K+ needing treatment may occur:

a) after cardiac bypass
b) in diabetic coma
c) after suxamethonium administration
d) after severe burns
e) after severe tissue damage.

Answer 8

a) after cardiac bypass
b) in diabetic coma
d) after severe burns
e) after severe tissue damage.

Question 9

The pressor response to intubation may be attenuated by:

a) calcium-channel blockers
b) thiopentone
c) fentanyl
d) angiotension-converting enzyme inhibitors
e) beta-blockers

Answer 9

a) calcium-channel blockers
b) thiopentone
c) fentanyl
e) beta-blockers

Question 10

The oculocardiac reflex is prevented by:

a) atropine
b) small increments of isoprenaline
c) retrobulbar block
d) deep anaesthesia
e) avoidance of traction on extraocular muscles

Answer 10

a) atropine
c) retrobulbar block
d) deep anaesthesia
e) avoidance of traction on extraocular muscles

Question 11

The MAC of isoflurane:

a) decreases with age
b) is decreased with acute alcohol intake
c) is lower in men than women
d) is higher in neonates compared to a 2-year-old
e) is decreased in pregnancy.

Answer 11

a) decreases with age
b) is decreased with acute alcohol intake
e) is decreased in pregnancy.

Question 12

The sympathoadrenal axis may be stimulated by:

a) etomidate
b) cyclopropane
c) halothane
d) methoxyflurane
e) di-ethyl ether

Answer 12

b) cyclopropane
e) di-ethyl ether

Question 13

Following intravenous thiopentone and suxamethonium, causes of lack of muscle relaxation include:

a) drug interaction
b) subcutaneous inactivation
c) porphyria
d) malignant hyperpyrexia
e) myotonia congenita

Answer 13

a) drug interaction
b) subcutaneous inactivation
d) malignant hyperpyrexia
e) myotonia congenita

Question 14

Concerning analgesic drugs:

a) paracetamol is an anti-inflammatory drug

b) toxic doses of aspirin increase the rate and depth of respirations

c) aspirin-like drugs shorten time for delivery of a fetus

d) indomethacin lowers a raised body temperature

e) aspirin displaces other drugs from plasma proteins

Answer 14

b) toxic doses of aspirin increase the rate and depth of respirations

d) indomethacin lowers a raised body temperature

e) aspirin displaces other drugs from plasma proteins

Question 15

Concerning analgesic drugs:

a) indomethacin is an addictive drug

b) paracetamol causes gastric irritation

c) unionised acetylsalicylic acid is absorbed more readily than the ionised form

d) the analgesic properties of indomethacin are best seen when pain is associated with inflammation

e) phenylbutazone is the drug of choice for headache

Answer 15

d) the analgesic properties of indomethacin are best seen when pain is associated with inflammation

Question 16

The following drugs may be safely used in porphyria:

a) barbiturates
b) bupivacaine
c) lignocaine
d) chlorpromazine
e) sulphonamides

Answer 16

b) bupivacaine
c) lignocaine
d) chlorpromazine