CLASP- sudden death Flashcards
What can long QT syndrome lead too?
Polymorphic VT or torsades des pointes which can become VF -> can result in syncope or sudden cardiac death
How can you diagnose long QT syndrome?
QTc >480ms in repeated 12 lead ECG
LQTs risk score >3
Presence of pathogenic mutation irrespective of QT duration
What can be triggers for LQTS
Strenous exercise- swimming, running (LQTS1)
Loud noises (LQTS2)
What causes short QT syndrome?
Mutation in cardiac K channels
What defines short QT syndrome?
QT <300ms at heart rate 80bpm
What is associated with short QT syndrome?
Atrial Fibrilliation
Features of Wolff-parkinson white syndrome?
Short PR interval
Delta wave
Ventricular pre-excitiation
What are the clinical presentations of hypertrophic cardiomyopathy?
Sudden death
Heart failure
Atrial fibrillation
What does array CHG do?
Compares the patient’s genome against a reference genome and identifies differences between the two genomes
What does next generation sequencing allow?
Sequence the coding parts of the genome (exome)
In genetics what is redundancy?
Where different codons can encode the same amino acid. So RNA sequence can change and cause no effect on protein sequence of amino acids
Acute mx of long QT?
Treat cause, Mg infusion, defib
What is the inheritance of long QT and brugada?
Autosomal dominant
What is brugada syndrome?
Inherited cardiac sodium channelopathy with ST elevation in atleast one anterior precordial leads (V1-V3) in a strucuturally normal heart
What are patients at risk of in brugada syndrome?
Polymorphic v tach or V fib -> Sudden cardiac death
