Caldwell Pharm

Question 1

Which 2 drugs have level 1 evidence for use in community acquired pneumonias in a non-ICU patient?

Answer 1

1) Respiratory Fluoroquinolones (Gemi, Moxi, and Levofloxacin) and 2) Beta-lactam + macrolide

Question 2

Which drugs have level 1 evidence for use in community acquired pneumonia in an ICU patient?

Answer 2

Beta-lactams and respiratory fluoroquinolones

Question 3

For an ICU patient with CAP what should be used instead of penicillins if there is an allergy? What about a non-ICU pt?

Answer 3

1) For ICU pt: fluoroquinolones and aztreonam and 2) fluoroquinolons

Question 4

What are the 4 options for Tx of P. aeruginosa CAP?

Answer 4

1) Beta-lactam and Cipro/levofloxacin 2) Beta-lactam and tobramycin 3) Gentamicin and Azithromycin or 4) Gentamicin and Respiratory fluoroquinolone

Question 5

What are 2 drugs for Tx of acute sinusitis? Which for M. catarrhalis?

Answer 5

1) Amoxicllin and TMP-SMX, M. catarrhalis is resistant to penicillins, so just TMP-SMX

Question 6

Which 5 drugs can be used for Tx of chronic sinusitis?

Answer 6

1) Clindamycin 2) Cefazolin/metronidazole 3) Cefuroxime/metronidazole 4) Clarithromycin 5) Fluoroquinolones

Question 7

Which intramuscular and oral agents can be used against streptococcal sore throat? What if penicillin allergy?

Answer 7

Intramuscular = Penicillin G Benzathine; Oral = Penicillin V; If allergic then erythromycin

Question 8

Which 3 agents can be used for COPD exacerbations?

Answer 8

1) TMP-SMX 2) Doxy and 3) Azithromycin and Clarithromycin

Question 9

Which 3 agents are used for highly penicillin-resistant pneumococcal infections?

Answer 9

1) Doxycycline 2) Clindamycin and 3) Levofloxacin

Question 10

2 antibiotics for Legionella:

Answer 10

Fluroquinolone and Azithromycin (Carty/Chen say Erythromycin)

Question 11

What are 3 agents that can be used for nosocomial pneumonia and MRSA?

Answer 11

Linezolid, Tigecycline, and Vancomycin

Question 12

A healthy patient with S. pneumoniae should be Tx’d with?

Answer 12

Macrolide, again Carty says ampicillin

Question 13

An outpatient w/ comorbidities and has S. pneumo should be Tx’d with:

Answer 13

Respiratory fluoroquinolone OR Beta-lactam + Macrolide

Question 14

What general class of drug is used in CAP patients over 60?

Answer 14

Cephalosporins (2nd gen Loracarbef and Cefuroxime; 3rd gen Cefpodoxime and Ceftriaxone)