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Repro Pharm - Keith > Ovarian and Bladder Cancer > Flashcards

Ovarian and Bladder Cancer Flashcards

1
Q

MOA of carboplatin

A

forms DNA intrastrand crosslinks and adducts

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2
Q

ADE of carboplatin

A

platinum allergic reactions.
Dose-related myelosuppression and anemia
Blood dyscrasia.
Hepatic dysfunction

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3
Q

MOA of cisplatin

A

forms DNA intrastrand crosslinks and adducts

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4
Q

ADE of cisplatin

A

platinum allergic reactions.
Dose related myelosuppression
Neprotoxicity
OTOTOXICITY –> deaf (platinum earrings)

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5
Q

MOA of cyclophosphamide

A

pro-drug of active alkylating moiety

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6
Q

ADE of cyclophosphamide

A

blood dyscrasias and anemia
nephrotoxicity
hemorrhagic cystitis (GIVE MESNA to protect)
Pulmonary fibrosis

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7
Q

MOA of doxorubicin

A

3 ways: intercalator, free radical generator, topo II inhibitor

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8
Q

ADE of doxorubicin

A

Dose limiting cardiotoxicity - give dexrazoxane to protect heart.
myelosuppression
CHF
extravasational necrosis

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9
Q

MOA of paclitaxel

A

microtubule stabilizer inhibitng depolymerizer

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10
Q

ADE of paclitaxel

A

peripheral neuropathy
taxane hypersensitivity
myelosuprression
myalgia and arthralgia

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11
Q

MOA of bacillus calmette-Guerin (BCG)

A

(think bacteria product that triggers immune system)
Binds to urothelial cells and activates APCs (antigen presenting cells). Induces production of effector cells (CTLs, NKs, LAKs, and BAKs) Requires an intact immune system.

Same as foreign TB vaccine

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12
Q

ADE of BCG

A

ineffective if patient is immunocompromised

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13
Q

MOA of mitomycin C

A

mono and bi-functional alkylating agent. DNA Crosslinker

MightyMycin alkylates 2 ways.

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14
Q

ADE of Mitomycin C

A

pancytopenia
pneumonitis
cystitis
contact dermatitis (palmar erythemas. piss on hands)

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15
Q

MOA of thiotepa

A

polyfunctional alkylator with loss of aziridine (alkylator) moiety. Also crosslinks DNA

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16
Q

ADE of thiotepa

A

pancytopenia
dysuria and urinary retention -> renal dysfunction
hemorrhagic cystitis

17
Q

What is CA-125 and what is it used for?

A

it is a cancer antigen protein that is elevated in most ovarian cancers. It is used to measure tumor stage and drug effectiveness. It is NOT useful for screening, but CAN be used to detect relapse

18
Q

Which drug would be ineffective in an immunocompromised patient?

A

BCG

Repro Pharm - Keith (11 decks)

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